2,340 research outputs found
Prenatal diagnosis of trisomy 6q25.3-qter and monosomy 10q26.12-qter by array CGH in a fetus with an apparently normal karyotype.
We present the prenatal case of a 12.5-Mb duplication involving 6q25-qter and a 12.2-Mb deletion encompassing 10q26-qter diagnosed by aCGH, while conventional karyotype showed normal results. The genotype-phenotype correlation between individual microarray and clinical findings adds to the emerging atlas of chromosomal abnormalities associated with specific prenatal ultrasound abnormalities
Maternal cell-free DNA-based screening for fetal microdeletion and the importance of careful diagnostic follow-up.
BackgroundNoninvasive prenatal screening (NIPS) by next-generation sequencing of cell-free DNA (cfDNA) in maternal plasma is used to screen for common aneuploidies such as trisomy 21 in high risk pregnancies. NIPS can identify fetal genomic microdeletions; however, sensitivity and specificity have not been systematically evaluated. Commercial companies have begun to offer expanded panels including screening for common microdeletion syndromes such as 22q11.2 deletion (DiGeorge syndrome) without reporting the genomic coordinates or whether the deletion is maternal or fetal. Here we describe a phenotypically normal mother and fetus who tested positive for atypical 22q deletion via maternal plasma cfDNA testing.MethodsWe performed cfDNA sequencing on saved maternal plasma obtained at 11 weeks of gestation from a phenotypically normal woman with a singleton pregnancy whose earlier screening at a commercial laboratory was reported to be positive for a 22q11.2 microdeletion. Fluorescence in situ hybridization and chromosomal microarray diagnostic genetic tests were done postnatally.ConclusionNIPS detected a 22q microdeletion that, upon diagnostic workup, did not include the DiGeorge critical region. Diagnostic prenatal or postnatal testing with chromosomal microarray and appropriate parental studies to determine precise genomic coordinates and inheritance should follow a positive microdeletion NIPS result
The evaluation methods of financial value of client in the banking sector
Π ΡΡΠ°ΡΡΡ Π²ΠΈΠ·Π½Π°ΡΠ΅Π½Π΅ ΠΌΡΡΡΠ΅ ΡΡΠ½Π°Π½ΡΠΎΠ²ΠΎΡ ΡΡΠ½Π½ΠΎΡΡΡ ΠΊΠ»ΡΡΠ½ΡΠ° Π² ΡΠΈΡΡΠ΅ΠΌΡ ΡΠΏΡΠ°Π²Π»ΡΠ½Π½Ρ Π²Π·Π°ΡΠΌΠΎΠ²ΡΠ΄Π½ΠΎΡΠΈΠ½Π°ΠΌΠΈ Π· ΠΊΠ»ΡΡΠ½ΡΠ°ΠΌΠΈ. ΠΡΠΎΠ°Π½Π°Π»ΡΠ·ΠΎΠ²Π°Π½Ρ ΡΠ°ΠΊΡΠΎΡΠΈ, ΡΠΎ Π²ΠΏΠ»ΠΈΠ²Π°ΡΡΡ Π½Π° Π²Π°ΡΡΡΡΡΡ ΠΆΠΈΡΡΡΠ²ΠΎΠ³ΠΎ ΡΠΈΠΊΠ»Ρ ΠΊΠ»ΡΡΠ½ΡΠ°. ΠΠ²ΡΠΎΡΠΎΠΌ ΡΠΎΠ·Π³Π»ΡΠ½ΡΡΡ ΠΏΠ΅ΡΠ΅Π²Π°Π³ΠΈ ΡΠ° Π½Π΅Π΄ΠΎΠ»ΡΠΊΠΈ ΡΠ°ΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΡΠ² ΠΎΡΡΠ½ΠΊΠΈ CLV, ΡΠΊ Π±Π°Π·ΠΎΠ²Π° ΡΡΡΡΠΊΡΡΡΠ½Π° ΠΌΠΎΠ΄Π΅Π»Ρ, ΠΌΠΎΠ΄Π΅Π»Ρ RFM, Π΅ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΡΠΈΡΠ½Ρ ΠΌΠΎΠ΄Π΅Π»Ρ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π° ΠΏΠΎΡΡΠ²Π½ΡΠ»ΡΠ½Π° Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΠΌΠ΅ΡΠΎΠ΄ΡΠ² ΠΎΡΡΠ½ΠΊΠΈ Π²Π°ΡΡΠΎΡΡΡ Π½Π΅ΠΊΠΎΠ½ΡΡΠ°ΠΊΡΠ½ΠΈΡ
ΠΊΠ»ΡΡΠ½ΡΡΠ². Π ΠΎΠ·Π³Π»ΡΠ½ΡΡΠ° ΠΌΠΎΠΆΠ»ΠΈΠ²ΡΡΡΡ ΠΎΡΡΠ½ΠΊΠΈ ΡΡΠ½Π½ΠΎΡΡΡ ΠΊΠ»ΡΡΠ½ΡΠ°, ΡΠΎ ΠΊΠΎΡΠΈΡΡΡΡΡΡΡΡ ΡΡΠ»ΡΠΊΠΈ Π΄Π΅ΠΏΠΎΠ·ΠΈΡΠ½ΠΈΠΌΠΈ ΠΏΡΠΎΠ΄ΡΠΊΡΠ°ΠΌΠΈ.Π ΡΡΠ°ΡΡΠ΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΎ ΠΌΠ΅ΡΡΠΎ ΡΠΈΠ½Π°Π½ΡΠΎΠ²ΠΎΠΉ ΡΠ΅Π½Π½ΠΎΡΡΠΈ ΠΊΠ»ΠΈΠ΅Π½ΡΠ° Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ Π²Π·Π°ΠΈΠΌΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡΠΌΠΈ Ρ ΠΊΠ»ΠΈΠ΅Π½ΡΠ°ΠΌΠΈ. ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΡΠ°ΠΊΡΠΎΡΡ, Π²Π»ΠΈΡΡΡΠΈΠ΅ Π½Π° ΡΡΠΎΠΈΠΌΠΎΡΡΡ ΠΆΠΈΠ·Π½Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠΈΠΊΠ»Π° ΠΊΠ»ΠΈΠ΅Π½ΡΠ°. ΠΠ²ΡΠΎΡΠΎΠΌ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° ΠΈ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠΈ ΡΠ°ΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΎΡΠ΅Π½ΠΊΠΈ CLV, ΠΊΠ°ΠΊ Π±Π°Π·ΠΎΠ²Π°Ρ ΡΡΡΡΠΊΡΡΡΠ½Π°Ρ ΠΌΠΎΠ΄Π΅Π»Ρ, ΠΌΠΎΠ΄Π΅Π»Ρ RFM, ΡΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π° ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½Π°Ρ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΎΡΠ΅Π½ΠΊΠΈ ΡΡΠΎΠΈΠΌΠΎΡΡΠΈ Π½Π΅ ΠΊΠΎΠ½ΡΡΠ°ΠΊΡΠ½ΡΡ
ΠΊΠ»ΠΈΠ΅Π½ΡΠΎΠ². Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΠ΅Π½Π½ΠΎΡΡΠΈ ΠΊΠ»ΠΈΠ΅Π½ΡΠ°, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΠΎΠ»ΡΠ·ΡΠ΅ΡΡΡ ΡΠΎΠ»ΡΠΊΠΎ Π΄Π΅ΠΏΠΎΠ·ΠΈΡΠ½ΡΠΌΠΈ ΠΏΡΠΎΠ΄ΡΠΊΡΠ°ΠΌΠΈ.The place of the financial value of the customer in the customer rela-tionship management was defined in this article. The factors affecting the value of a customer life cycle were analyzed. The author considered the advantages and disadvantages of CLV methods such as a basic structural model, RFM model, econometric models. The comparative characteristic of evaluating methods of non-contractual customerβs value was conducted. The possibility of evaluating client who uses only deposit products was considered
Information systems as support of customer relationship management in banks
ΠΠ²ΡΠΎΡΠΎΠΌ Π²ΠΈΠ·Π½Π°ΡΠ΅Π½Π° ΡΠΎΠ»Ρ ΡΠ½ΡΠΎΡΠΌΠ°ΡΡΠΉΠ½ΠΈΡ
ΡΠΈΡΡΠ΅ΠΌ Π² ΡΠΏΡΠ°Π²Π»ΡΠ½Π½Ρ Π±Π°Π½ΠΊΠΎΠΌ Π² ΡΠΈΡΠΎΠΊΠΎΠΌΡ ΡΠ° Π²ΡΠ·ΡΠΊΠΎΠΌΡ ΡΠΎΠ·ΡΠΌΡΠ½Π½Ρ ΡΠ΅ΡΠΌΡΠ½Ρ. Π£ ΡΡΠ°ΡΡΡ ΡΠΎΠ·Π³Π»ΡΠ½ΡΡΠΎ ΠΏΠ΅ΡΠ΅Π΄ΡΠΌΠΎΠ²ΠΈ ΡΠ° ΡΠ°ΠΊΡΠΎΡΠΈ ΡΠΎΠ·Π²ΠΈΡΠΊΡ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠ½ΠΎΠ³ΠΎ Π·Π°Π±Π΅Π·ΠΏΠ΅ΡΠ΅Π½Π½Ρ Π΄Π»Ρ Π·Π΄ΡΠΉΡΠ½Π΅Π½Π½Ρ ΠΌΠ°ΡΠΊΠ΅ΡΠΈΠ½Π³ΠΎΠ²ΠΎΡ Π΄ΡΡΠ»ΡΠ½ΠΎΡΡΡ. ΠΡΠΎΠ°Π½Π°Π»ΡΠ·ΠΎΠ²Π°Π½ΠΎ ΠΎΡΠ½ΠΎΠ²Π½Ρ Π΅ΡΠ°ΠΏΠΈ ΡΠΎΠ·Π²ΠΈΡΠΊΡ ΡΠ½ΡΠΎΡΠΌΠ°ΡΡΠΉΠ½ΠΈΡ
ΡΠΈΡΡΠ΅ΠΌ Π΄Π»Ρ ΠΏΡΠ΄ΡΡΠΈΠΌΠΊΠΈ ΠΏΡΠΈΠΉΠ½ΡΡΡΡ ΠΌΠ°ΡΠΊΠ΅ΡΠΈΠ½Π³ΠΎΠ²ΠΈΡ
ΡΡΡΠ΅Π½Ρ Π² Π±Π°Π½ΠΊΠ°Ρ
, ΡΡ
ΡΡΠ½ΠΊΡΡΠΎΠ½Π°Π»ΡΠ½Π΅ ΠΏΡΠΈΠ·Π½Π°ΡΠ΅Π½Π½Ρ. ΠΠ²ΡΠΎΡ ΡΠ°ΠΊΠΎΠΆ Π²ΠΈΠ·Π½Π°ΡΠΈΠ² ΠΎΡΠ½ΠΎΠ²Π½Ρ Π²ΠΈΠΊΠ»ΠΈΠΊΠΈ ΠΌΠ°ΠΉΠ±ΡΡΠ½ΡΠΎΠ³ΠΎ, ΡΠΊΡ ΠΌΠ°ΡΡΡ Π±ΡΡΠΈ Π²ΡΠ΄ΠΎΠ±ΡΠ°ΠΆΠ΅Π½Ρ Ρ ΡΡΠ½ΠΊΡΡΡΡ
ΡΠ½ΡΠΎΡΠΌΠ°ΡΡΠΉΠ½ΠΈΡ
ΡΠΈΡΡΠ΅ΠΌ ΡΡΡΠ°ΡΠ½ΠΈΡ
Π±Π°Π½ΠΊΡΠ².ΠΠ²ΡΠΎΡΠΎΠΌ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π° ΡΠΎΠ»Ρ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΡΠΈΡΡΠ΅ΠΌ Π² ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΈ Π±Π°Π½ΠΊΠΎΠΌ Π² ΡΠΈΡΠΎΠΊΠΎΠΌ ΠΈ ΡΠ·ΠΊΠΎΠΌ ΠΏΠΎΠ½ΠΈΠΌΠ°Π½ΠΈΠΈ ΡΠ΅ΡΠΌΠΈΠ½Π°. Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΠΏΡΠ΅Π΄ΠΏΠΎΡΡΠ»ΠΊΠΈ ΠΈ ΡΠ°ΠΊΡΠΎΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ½ΠΎΠ³ΠΎ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ Π΄Π»Ρ ΠΎΡΡΡΠ΅ΡΡΠ²Π»Π΅Π½ΠΈΡ ΠΌΠ°ΡΠΊΠ΅ΡΠΈΠ½Π³ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π±Π°Π½ΠΊΠΎΠ². ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ ΡΡΠ°ΠΏΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΡΠΈΡΡΠ΅ΠΌ Π΄Π»Ρ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΠΈ ΠΏΡΠΈΠ½ΡΡΠΈΡ ΠΌΠ°ΡΠΊΠ΅ΡΠΈΠ½Π³ΠΎΠ²ΡΡ
ΡΠ΅ΡΠ΅Π½ΠΈΠΉ Π² Π±Π°Π½ΠΊΠ°Ρ
, ΠΈΡ
ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ΅ Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅. ΠΠ²ΡΠΎΡ ΡΠ°ΠΊΠΆΠ΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΠ» ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ Π²ΡΠ·ΠΎΠ²Ρ Π±ΡΠ΄ΡΡΠ΅Π³ΠΎ, ΠΊΠΎΡΠΎΡΡΠ΅ Π΄ΠΎΠ»ΠΆΠ½Ρ Π±ΡΡΡ ΠΎΡΡΠ°ΠΆΠ΅Π½Ρ Π² ΡΡΠ½ΠΊΡΠΈΡΡ
ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΡΠΈΡΡΠ΅ΠΌ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
Π±Π°Π½ΠΊΠΎΠ².The author defined the role of information systems in the bankβs management in broad and narrow sense of the term. The article describes the conditions and factors of development of software for
marketing activities in banks. The main stages of development of information systems for support decision making in bank marketing, their functional purpose were analyzed. The author also identified
the main challenges of the future, which should be reflected in the functions of the information systems in modern banks
Frequency-modulation saturation spectroscopy of molecular iodine hyperfine structure near 640 nm with a diode laser source
In a frequency-modulation spectroscopy experiment, using the radiation from a
single frequency diode laser, the spectra of molecular iodine hyperfine
structure near 640 nm were recorded on the transition
. The frequency reference given by the value
of the modulation frequency (12.5 MHz in given experiment) allows determination
of the frequency differences between hyperfine components with accuracy better
than 0.1 MHz using the fitting procedure in experiment with only one laser.Comment: 3 pages, 3 figure
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