Influence on the character of films used for density control of an automatic processor by the difference in the way of preserving

自動現像機の濃度管理に用いられるフィルムの保存については，種々の報告がなされており，最良の方法が確立されているとは言い難い。さらに，レギュラフィルムとオルソフィルムの保存方法の違いによる濃度管理への影響，あるいはこれらの比較については，これまでほとんど報告されていない。本論文では，われわれは，レギュラフィルム，フジnew-RXとオルソフィルム，コニカSR-G，SR－VおよびSR-Hを用い，開封後，室温，冷蔵，冷凍の3種類の保存方法を採用した。われわれは，35週間3種類の保存方法で4種類 のフィルムのgross　fog，speed indexとaverage gradientへの影響を調査した。その結果レギュラフィルムは，3種類の保存方法による差が認められなかった。オルソフィルムでは，冷蔵・冷凍保存に大きな特性変動が認められた。その原因として，オルソフィルムは増感色素が結露に対して敏感に影響を受けたと考えられた。Though there are various reports on the way of preserving films used for density control of the automatic processor, it is hard to say that the best method isestablished. In　addition, the influences on density control or their comparisons by the difference way of preserving film between regular and orthochromatic films have been hardly reported until now. In this paper, three ways of preserving films were employed, which were at a room temperature, in a refrigeration and in a freezer after the films were opened, using a regular film, Fuji new-RX and three orthochromatic films, Konica SR-G, SR-V and SR-H. We investigated the influences on gross fog, speed index and average gradient of four films on three different ways of preserving film for 35 weeks. As a result, new-RX film wasn't influenced by the ways of the preservation. On the other hand, the orthochromatic films were so influences sensitively that the films couldn't be used for density control. It was considered that sensitizing dye stuff got denatured by dew condensation

Patient Dose on the Radiological Diagnosis of Abdomen - The Situation of Patient nose at Hospitals in Okayama Prefecture -

In 1995, we have published a paper about the basic data on the relation between X-ray exposure equipment and patient dose in Vol. 17 of the Journal "Environment Research and Control". In this time, we questioned hospitals in Okayama Prefecture about exposure equipments of abdomen. And we compared each hospital's exposure equipments with the basic data, calculated each patient dose, then we studied that differences. Various imaging system, for example; screen/film or imaging plate has been used at each hospitals, so that exposure are various and patient doses are very different. The exposure equipment decide that the X-ray photograph is good or bad, so we cannot treat it easily. But we think that we have to try to take X-ray photographs which are suit the purpose of diagnosis which as a small patient dose as possible

Long‑term effect of sitagliptin on endothelial function in type 2 diabetes : a sub‑analysis of the PROLOGUE study

Background: As a sub-analysis of the PROLOGUE study, we evaluated the long-term effect of sitagliptin, a dipeptidyl peptidase 4 inhibitor, on endothelial function in the conduit brachial artery in patients with type 2 diabetes. Methods: In the PROLOGUE study, patients were randomly assigned to either add-on sitagliptin treatment (sitagliptin group) or continued conventional antihyperglycemic treatment (conventional group). Among the 463 participants in the PROLOGUE study, FMD was measured in 17 patients in the sitagliptin group and 18 patients in the conventional group at the beginning and after 12 and 24 months of treatment. Results: HbA1c levels were significantly decreased after 12 and 24 months of treatment compared to baseline values in both groups (7.0 ± 0.4 vs. 6.6 ± 0.3 and 6.6 ± 0.4 % in the sitagliptin group; 7.0 ± 0.6 vs. 6.6 ± 0.7 and 6.6 ± 0.7 % in the conventional group; P < 0.05, respectively). There was no significant difference between FMD values at baseline and after 12 and 24 months in the sitagliptin group (4.3 ± 2.6 vs. 4.4 ± 2.1 and 4.4 ± 2.3 %, P = 1.0, respectively). Although FMD had a tendency to increase from 4.3 ± 2.4 % at baseline to 5.2 ± 1.9 % after 12 months and 5.1 ± 2.2 % after 24 months in the conventional group, there was no significant difference between FMD values at baseline and after 12 and 24 months (P = 0.36 and 0.33, respectively). Conclusions: Add-on sitagliptin to conventional antihyperglycemic drugs in patients with type 2 diabetes did not alter endothelial function in the conduit brachial artery measured by FMD during a 2-year study period. Sitagliptin may be used without concern for an adverse effect on endothelial function in patients with type 2 diabetes

Relationship between X-ray Exposure and Patient Dose on the Radiological Diagnosis

Patient dose is important consideration in the radiological examination and our environment regarding radiation. Many studies have been published about patient dose, but those data were classified by each organ or tissue. Actuarially, patient dose should be checked by each examined part of patient and each exposure equipment. In this paper, we measured absorbed dose at the depth of 0-200mm with the Mix-DP phantom. The phantom is made by tissue equivalent meterial and is designed to similitude abdominal part. Percentage Depth Dose (PDD) was calculated from these doses. Three single-phase generators and three three-phases generators were used in this measurement. These measurements were analyzed by each equipment, and consequently the clear difference of PDD between the exposure equipments was not found. As the result, we can estimate patient dose at a random depth by using PDD. Furthermore, we can easily know patient dose from the tube-voltage and current time product by the calculation including PDD.These data are very useful to manager patient dose on radiological diagnosis

Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes : A Prospective Multicenter Study

The dipeptidyl peptidase-4 inhibitor saxagliptin is a widely used antihyperglycemic agent in patients with type 2 diabetes. The purpose of this study was to evaluate the effects of saxagliptin on endothelial function in patients with type 2 diabetes. This was a prospective, multicenter, interventional study. A total of 34 patients with type 2 diabetes were enrolled at four university hospitals in Japan. Treatment of patients was initially started with saxagliptin at a dose of 5 mg daily. Assessment of endothelial function assessed by flow-mediated vasodilation (FMD) and measurement of stromal cell-derived factor-1α (SDF-1α) were conducted at baseline and at 3 months after treatment with saxagliptin. A total of 31 patients with type 2 diabetes were included in the analysis. Saxagliptin significantly increased FMD from 3.1 ± 3.1% to 4.2 ± 2.4% (P = 0.032) and significantly decreased total cholesterol from 190 ± 24 mg/dL to 181 ± 25 mg/dL (P = 0.002), glucose from 160 ± 53 mg/dL to 133 ± 25 mg/dL (P < 0.001), HbA1c from 7.5 ± 0.6% to 7.0 ± 0.6% (P < 0.001), urine albumin-to-creatinine ratio from 63.8 ± 134.2 mg/g to 40.9 ± 83.0 mg/g (P = 0.043), and total SDF-1α from 2108 ± 243 pg/mL to 1284 ± 345 pg/mL (P < 0.001). These findings suggest that saxagliptin is effective for improving endothelial function

Diagnostic Criteria of FMD and NID

Background - Diagnostic criteria of flow-mediated vasodilation (FMD), an index of endothelial function, and nitroglycerin-induced vasodilation (NID), an index of vascular smooth muscle function, of the brachial artery have not been established. The purpose of this study was to propose diagnostic criteria of FMD and NID for normal endothelial function and normal vascular smooth muscle function. Methods and Results - We investigated the cutoff values of FMD and NID in subjects with (risk group) and those without cardiovascular risk factors or cardiovascular diseases (no-risk group) in 7277 Japanese subjects (mean age 51.4±10.8 years) from the Flow-Mediated Dilation Japan study and the Flow-Mediated Dilatation Japan Registry study for analysis of the cutoff value of FMD and in 1764 Japanese subjects (62.2±16.1 years) from the registry of Hiroshima University Hospital for analysis of the cutoff value of NID. Receiver-operator characteristic curve analysis of FMD to discriminate subjects in the no-risk group from patients in the risk group showed that the optimal cutoff value of FMD to diagnose subjects in the no-risk group was 7.1%. Receiver-operator characteristic curve analysis of NID to discriminate subjects in the no-risk group from patients in the risk group showed that the optimal cutoff value of NID to diagnose subjects in the no-risk group was 15.6%. Conclusions - We propose that the cutoff value for normal endothelial function assessed by FMD of the brachial artery is 7.1% and that the cutoff value for normal vascular smooth muscle function assessed by NID of the brachial artery is 15.6% in Japanese subjects

Immune-related aseptic meningitis diagnosed by Cube FLAIR on enhanced magnetic resonance imaging for a lung cancer patient administered atezolizumab: A case report

Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs), such as neurological toxicity. A 46-year-old man was diagnosed with squamous cell lung cancer. Lung cancer recurred 3 years after he experienced left segmental lung rejection. Therefore, he received atezolizumab as fourth-line chemotherapy. He experienced fever, headache, and decreased consciousness 10 days after the first dose of atezolizumab. Plain head computed tomography and cerebrospinal fluid examination showed no significant findings. Magnetic resonance imaging (MRI) with a Gadolinium (Gd)-enhanced Cube fluid-attenuated inversion recovery (FLAIR) sequence showed nodular abnormalities with contrast enhancement. Thus, aseptic meningitis caused by ICIs was suspected. His consciousness level gradually improved with glucocorticoid therapy. Moreover, most nodular abnormalities observed on cerebral MRI disappeared concurrently. Thus, Gd-enhanced Cube FLAIR sequence has the unique ability to reveal immune-related aseptic meningiti