Molluscicidal Activity of Methomyl and Cardenolide Extracts from Calotropis procera and Adenium arabicum Against the Land Snail Monacha cantiana

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Fumigant Toxicity and Feeding Deterrent Activity of Essential Oils from <i>Lavandula dentata</i>, <i>Juniperus procera</i>, and <i>Mentha longifolia</i> against the Land Snail <i>Monacha obstructa</i>

Land mollusks are one of the most destructive agricultural pests worldwide, the management of which depends on synthetic molluscicides. However, many of these molluscicides are harmful to nontarget organisms. Hence, there is a need to develop alternative ecofriendly molluscicides that are less impactful toward nontarget organisms. So, an investigation into the fumigant toxicity and feeding deterrent effect of essential oils (EOs) from Lavandula dentata L. (Lamiaceae), Juniperus procera Hochst. (Cupressaceae), and Mentha longifolia (L.) Huds. (Lamiaceae) against the land snail Monacha obstructa (Pfeiffer, 1842) (Hygromiidae) was performed. L. dentata EO exhibited the highest fumigant toxicity with LC50 values of 8.68 μL/L air and 7.24 μL/L air after 24 h and 48 h exposure periods, respectively. Its main components were camphor, 1,8-cineole, fenchone, and β-myrecene. The fumigant toxicity of J. procera EO was lower than that of L. dentata, with LC50 values of 25.63 μL/L air and 20.11 μL/L air after 24 h and 48 h exposure periods, respectively. The major constituents of J. procera EO were α-pinene, p-cymene, and β-ocimene. The analysis of M. longifolia EO showed that pulegone, and menthol were the major constituents. However, it displayed no fumigant toxicity up to 50 μL/L air. The three EOs exhibited a strong feeding deterrent effect at sublethal concentrations. The EOs extracted from L. dentata, J. procera and M. longifolia are promising ecofriendly botanical molluscicides against the land snail M. obstructa

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research