1,2-Dihydroxybenzene 類縁体を用いる特定ペプチドに選択的な蛍光反応とコラーゲンアッセイへの応用

長崎大学学位論文 [学位記番号]博（医歯薬）甲第545号 [学位授与年月日]平成24年9月20

Clinical status of COVID-19 vaccinated pregnant women: an observational study in a tertiary care hospital in Bangladesh

Background: Pregnancy is a special but often stressful time. The COVID-19 pandemic exacerbated this stress. Clinical trials have demonstrated the safety of COVID-19 vaccines for pregnant and lactating women, leading to WHO approval. Consequently, the Bangladesh Government has initiated a vaccination campaign for all expectant mothers to protect them from COVID-19. This study aimed to assess the clinical status of COVID-19-vaccinated pregnant women. Methods: A cross-sectional study was carried out at Department of Obstetrics & Gynaecology in Combined Military Hospital, Dhaka Cantonment, Bangladesh, spanning August to November 2021. The study included 50 pregnant women who had received COVID-19 vaccinations, selected through purposive sampling. Data analysis and dissemination were performed using MS Office tools. Results: The study found that the average age was 19.2±10.8 years, with 66% falling into the 25-35 age group. About 50% had a normal BMI, while 22% were overweight (BMI: 25.0-29.9 Kg/m2). Hypertension and diabetes were present in 16% and 12% of cases, respectively. Among the 50 pregnant women, 40% were nulliparous, and 60% were multiparous; in most of the cases (54%), multigravidity (1-5) was found. Vaccination distribution was 28% in the 1st trimester, 54% in the 2nd, and 18% in the 3rd trimester. Conclusions: COVID-19 vaccination rates are notably higher among pregnant women aged 25-35. The frequency of normal BMI among COVID-19-vaccinated pregnant women is satisfactory. Most pregnant women opt for COVID-19 vaccination during their second trimester

Dystonia: A Leading Neurological Movement Disorder

Dystonia is the third leading movement disorder arising mainly from the damage of basal ganglia or other parts of the brain that control movements. The objective of this review is to represent the detailed profile of dystonia. A computerized literature review was conducted in authentic scientific databases including PubMed, Google Scholar, Scopus, Science Direct and National Institutes of Health (NIH) etc. Terms searched included dystonia, risk factors, etiologies, clinical features, classification, pathology, guidelines, treatment strategies, primary and secondary dystonia. Initially, 97 articles and 9 books were extracted but finally, 64 articles and 7 books were used. After analysis, we found that causes of dystonia could be acquired or inherited and dystonia can be classified based on age at onset, etiology, and distribution of the affected body parts. The risk factors of this heterogeneous disorder could be trauma, thyroid disorder, hypertension, life habits, occupation, use of drugs and genetics. A significant number of articles were found which signify the ability of brainstem and cerebellar pathology to trigger the symptoms of dystonia. Since antipsychotic drugs are the most commonly prescribed among the people with intellectual disability (ID), therefore they possess a greater risk to experience antipsychotic drugs-induced movement side effects including acute dystonia, parkinsonism, tardive dyskinesia, and akathisia. Depending on various manifestations and causes, there are several treatment options including oral medications, intramuscular injection of botulinum toxin, neurosurgical procedures and occupational therapy

1,2-Dihydroxybenzene 類縁体を用いる特定ペプチドに選択的な蛍光反応とコラーゲンアッセイへの応用

長崎大学学位論文 [学位記番号]博（医歯薬）甲第545号 [学位授与年月日]平成24年9月20

Preliminary Anti-bacterial Activity of Some Indigenous Plants of Bangladesh

ABSTRACT: The antibacterial activity of petroleum ether, carbon tetrachloride and chloroform soluble fractions of crude methanol extracts of nine indigenous plant species of Bangladesh was evaluated by the agar diffusion method. Kanamycin (30 µg/disc) was used as a standard antibacterial agent. The results indicated that all the nine plant species (not all partitionates) exhibited moderate to potent antibacterial activity against a wide variety of gram- positive and gram-negative bacteria at a concentration of 400µg/disc. Among them the carbon tetrachloride soluble fraction of whole plant extract of Corriandrum sativum (family-Apiaceae) revealed the highest antibacterial activity against Shigella boydii with zone of inhibition of 29 mm

Total synthesis and analgesic activity of 6-fluoroindan-1-carboxylic acid

6-Fluoroindan-1-carboxylic acid (4) was conveniently synthesised from 3-fluorobenzaldehyde in six steps. The structure of this new compound and three other intermediates, 3-fluorophenylcyanoethylacrylate (1), 3-fluorophenyl succinic acid (2) and 6-fluoro-3-oxo-indan-1-carboxylic acid (3) was elucidated by comprehensive spectral data analyses. The analgesic activity of compounds 3 and 4 was assessed by the acetic acid induced writhing in Swiss albino mice