Modified Electromagnetic Actuator for Active Suspension System

Active suspension is a type of suspension systems which can vary its damping value in order to adjust the spring firmness in accordance with the road conditions. Real Active Suspension incorporates an external actuator which helps in raising or lowering of vehicle chassis independently at each wheel. Generally, the actuators that are used for active suspension are Hydropneumatic, Electro-hydraulic or Electromagnetic actuators. A new concept of two-way electromagnetic actuation with the help of magnetic damping is proposed in this paper, which can extend its arm on both sides to facilitate active suspension mechanism in both humps and potholes. This increases the ride quality while maneuvering not only in humps, but also in dumps. It also describes about the comparison of spring materials, sophisticated design, construction and working principle of newly proposed actuator. Catia V5 software has been used to design and simulate the actuator model, different spring materials are analyzed and their shear stress and deflections are compared

NetPath: a public resource of curated signal transduction pathways

NetPath, a novel community resource of curated human signaling pathways is presented and its utility demonstrated using immune signaling data

Mechanical characterization & regression analysis of Calamus rotang based hybrid natural fibre composite with findings reported on retrieval bending strength

Abstract Research on Bio-based natural fiber material promoted the development of reinforcement and expand their possible structural applications. In this study, fibers are extracted from the stem of Calamus rotang (common rattan-Indian Species). Further, the fiber is processed to get novel hybrid combinations with glass fibers by manual hand lay-up technique. Three sets of samples were prepared for the different volume fractions of 60:40, 30:30:30, and 60:32:8 of glass fiber/epoxy as neat composite sample (NCS), a hybrid combination of C. rotang /glass fiber with epoxy as modified reinforced composite sample (MRCS) and glass fiber/epoxy with calamus stem powder as modified matrix composite sample (MMCS) respectively. Mechanical tests including tensile, flexural, impact, and ILSS tests are conducted as per ASTM Standards. Comparative studies have been done to evaluate the effect of novel species of C. rotang on mechanical properties with neat GFRP composites. Addition to this regression analysis has been carried out to achieve the experimental correlation for tensile and bending tests. Microstructural analysis for all the tested samples has been done to assess the fracture mode. Novel findings on retrieval bending strength for MMCS has been reported for the first time for composite materials. Study proves that novel species have a significant impact on the basic properties of materials

Lupus nephritis in a patient with retroviral infection

A 38-year-old woman, diagnosed as Person Living with Human Immunodeficiency Virus (HIV) on Highly Active Antiretroviral Therapy (HAART) for three years, presented with features of fever, rashes, joint pain, dyspnea and pedal edema. On evaluation, a diagnosis of Systemic Lupus Erythematosus with Lupus Nephritis (LN) triggered by HIV infection was made based on clinical and serological evidence. She was continued on HAART, and immuno-suppressive therapy was co-administered resulting in the resolution of her symptoms. Lupus-like histopathological findings have been reported in patients with HIV-related kidney diseases. This case report is to highlight the co-existence of LN in a patient with HIV infection

Discovery of compounds inhibiting the ADP-ribosyltransferase activity of pertussis toxin

Abstract The targeted pathogen-selective approach to drug development holds promise to minimize collateral damage to the beneficial microbiome. The AB₅-topology pertussis toxin (PtxS1-S5) is a major virulence factor of Bordetella pertussis, the causative agent of the highly contagious respiratory disease whooping cough. Once internalized into the host cell, PtxS1 ADP-ribosylates α-subunits of the heterotrimeric Gαi-superfamily, thereby disrupting G-protein-coupled receptor signaling. Here, we report the discovery of the first small molecules inhibiting the ADP-ribosyltransferase activity of pertussis toxin. We developed protocols to purify milligram-levels of active recombinant B. pertussis PtxS1 from Escherichia coli and an in vitro high throughput-compatible assay to quantify NAD⁺ consumption during PtxS1-catalyzed ADP-ribosylation of Gαi. Two inhibitory compounds (NSC228155 and NSC29193) with low micromolar IC₅₀-values (3.0 μM and 6.8 μM) were identified in the in vitro NAD⁺ consumption assay that also were potent in an independent in vitro assay monitoring conjugation of ADP-ribose to Gαi. Docking and molecular dynamics simulations identified plausible binding poses of NSC228155 and in particular of NSC29193, most likely owing to the rigidity of the latter ligand, at the NAD⁺-binding pocket of PtxS1. NSC228155 inhibited the pertussis AB₅ holotoxin-catalyzed ADP-ribosylation of Gαi in living human cells with a low micromolar IC₅₀-value (2.4 μM). NSC228155 and NSC29193 might prove to be useful hit compounds in targeted B. pertussis-selective drug development