Can Propranolol be used as the first line treatment in infantile hemangioma?

Hemangiomas are the most common tumors of infancy. Most of them require no treatment, but treatment is needed if dramatic aesthetic, and/or functional impairment as visual or airway obstruction or ulceration arises. We reported a 6-month-old infant presented with a 6-week history of a rapidly growing cutaneus hemangioma on the right eyelid and caused visual impairment. The patient was successfully treated with the use of oral propranolol therapy. We suggest that propranolol can be considered as a first line treatment in a patient with infantil hemangioma

Hypopituitarism and Legg-Calve-Perthes disease related to difficult delivery

Legg-Calve-Perthes (LCP) disease is characterized by idiopathic avascular osteonecrosis of the epiphysis of the femur head. The main factor that plays a role in the etiology of the disease is decreased blood flow to the epiphysis. Many predisposing factors have been suggested in the etiology of LCP disease, and most have varying degrees of effects. Here we present the case of a boy aged 4 years and 10 months with complaints of short stature and a diagnosis of multiple hypophyseal hormone deficiency, in whom LCP disease and difficult birth-related pituitary stalk interruption syndrome were identified by anamnesis. The present case revealed that LCP disease and hypophyseal hormone deficiency could be secondary to difficult birth and that LCP disease could be secondary to insulin-like growth factor 1 deficiency. Additionally, to the best of our knowledge there is no published case on the relation between LCP disease and insulin-like growth factor 1 deficiency. Therefore, we believe that this case is worthy of presentation

Oküloglandüler tularemi : Olgu sunumu

Tularemi Francisella tularensis?in sebep olduğu bir infeksiyon hastalığıdır. Başlıca, mikroorganizmalar için bir reservuar olan kemirgenleri etkileyen zoonozdur. İnsana bulaşması vektörlerin ısırmasıyla, enfekte hayvan leşleri ile temas veya kontamine yiyeceklerin oral alınması gibi muhtelif yollarla olur. Vücuda giriş yerine bağlı olarak yedi klinik formu vardır. Ülseroglanduler form en sık, oküloglandüler form ise en az görülen şeklidir. Tularemi dünyanın pek çok yerinde salgınlara yol açabilir. Türkiye?de Marmara ve Karadeniz bölgesinde küçük salgınlar bildirilmiştir. Üst servikal lenfadenopati ve orbital şişlik ile başvuran adolesan hastaya tularemi mikroaglutinasyon test pozitifliği ile tularemi tanısı kondu ve streptomisinle tedavi edildi. Biz bu oldukça nadir görülen olguyu paylaşarak bilgi ve değerlendirmelerimizi tazelemeyi amaçladık.Tularemia is an infection disease caused by Francisella tularensis. It is primarily a zoonosis, affecting mainly the rodents, which can serve as a reservoir for the microorganism. The transmission to human usually occurs through several ways such as a bite of the vectors, by handling an infected carcass or by taking in a contaminated food orally. There are seven clinical forms of the disease that makes up of depending on the body entrance. The ulceroglandular form is the most frequently encountered manifestation but those at least seen is the oculoglandular form. Tularemia may cause outbreaks in many part of the world. Small epidemics were reported from the Marmara and the Black Sea regions of Turkey. The adolesan case was presented with upper cervical lymphadenopathy and orbital swelling. It was diagnosed as tularemia by the positivity of the tularemia microaglutination test, and treated by streptomycin. We aimed to share in such as a rare case to refresh our knowledge and consideration at all

The effects of acute and regular exercise on calcium, phosphorus and trace elements in young amateur boxers

Background: The aim of this study was to assess the acute and chronic effects of vigorous physical activity, with and without zinc supplementation, on distribution of elements in young amateur boxers. Methods: The 8 week intervention trial experiment was designed with 32 healthy adolescent males in three parts: part 1, a 1 hour boxing training program; part 2, 4 weeks of regular boxing training without any supplementation; part 3, 4 weeks of regular boxing training with supplementation of pills containing 50 mg oral zinc. Plasma calcium, phosphorus, zinc, iron, copper, and magnesium levels of all participants were measured before and after each part of the study. Results: After acute exercise serum calcium, zinc, copper levels decreased (p 0.05). However, after 4 weeks of regular boxing training there was a decrease in zinc (93.92 ± 9.03 μg/dL vs. 85.86 ± 10.32 μg/dL, p < 0.001) and an increase in calcium concentrations (9.62 ± 0.34 μg/dL vs. 9.90 ± 0.26 μg/dL, p < 0.001). Zinc supplementation increased plasma calcium, phosphorus, and iron and decreased copper and magnesium (p < 0.001). Conclusions: The body element distribution of children in pubertal age changes with physical activities. Zinc supplementation can negatively affect their magnesium and copper concentrations

Soluble Receptor for Advanced Glycation End Products (sRAGE) Level and Its Prognostic Significance in Children with Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemias are the most common malignancies in childhood. Although its etiology is still unclear, it is thought that disorders in oxidative stress metabolism may contribute to leukemogenesis. Advanced glycation end products (AGEs) are formed as a result of the non-enzymatic binding of sugars to biomolecules. Oxidation reactions are triggered through AGE–Receptor (RAGE) interaction, resulting in the formation of reactive oxygen species. These can play crucial roles in cancer pathogenesis and leukemogenesis. It is thought that sRAGE (soluble RAGE) is the end product of glycation and circulates freely in the circulation by binding to RAGE ligands. We investigate novel leukemia biomarkers and focus on soluble RAGE (sRAGE) for acute lymphoblastic leukemia (ALL) diagnosis and prognosis. Thirty children (1–17 years) diagnosed with ALL were included in the study. Patients were divided into standard, medium, and high risk groups according to the Berlin–Frankfurt–Münster (BFM) treatment protocol. Patients were evaluated twice; at the time of diagnosis and at the sixth month of remission. sRAGE and blood parameters were compared with healthy controls (n = 30, 1–17 years). The sRAGE levels in ALL patients at diagnosis (138.7 ± 177.3 pg/mL) were found to be significantly higher than they were during the sixth month of remission (17.6 ± 21.1 pg/mL) and in healthy controls (22.2 ± 23.7 pg/mL). The cut-off value of the sRAGE level for the diagnosis of ALL was found to be 45 pg/mL in ROC analysis (sensitivity: 73.3%, specificity: 86.7%, AUC: 0.681). At the same time, the sRAGE level was found to be significantly higher in T-ALL patients (490.9 ± 236.9 pg/mL) than in B-ALL patients (84.5 ± 82.7 pg/mL). No significant difference was found in terms of the sRAGE level between standard (45.8± 33.1 pg/mL), medium (212 ± 222.1 pg/mL), and high (143.9 ± 111.5 pg/mL) risk group ALL patients classified according to the BFM protocol. Despite the fact that this was a small, single-center study, our findings highlight the potential use of sRAGE as a biomarker for diagnosing ALL and assessing response to treatment