A study on the significance of anti-endothelial cell antibodies in chronic obstructive pulmonary disease and the effect of methylprednisolone intervention: DOI: 10.14800/ics.1210

Objective: The purpose was to confirm the significance of Anti-endothelial cell antibodies(AECA) in chronic obstructive pulmonary disease (COPD) and validate the effect of methylprednisolone intervention. Methods: We recruited 40 patients with stable COPD, 40 patients with an acute exacerbation of COPD, and 20 healthy volunteers from March 2019 to August 2021. The healthy volunteers constituted the healthy control group. All patients with stable COPD were divided into the mild-moderate COPD group and the severe-very severe COPD group, for whom AECA and vascular endothelial growth factor (VEGF) in peripheral blood were detected by ELISA. The patients with acute exacerbation of COPD were divided into routine treatment group and methylprednisolone group by random number method. The routine group received routine treatment, and the methylprednisolone group was treated with methylprednisolone on the basis of routine treatment, and the course of treatment was 1 week, respectively. The AECA and VEGF in the peripheral blood of the two groups of patients before and after treatment were detected by ELISA. Results: Compared to control group, the AECA concentration was significantly elevated as the condition of COPD got serious between mild-moderate COPD group and the severe-very severe COPD group(P<0.05). And VEGF concentration was significantly lower as the condition of COPD got serious(P<0.05). AECA concentration was significantly lower after methylprednisolone treatment than before in patients with COPD exacerbation, and significantly lower than patients receiving the routine treatment (P<0.05). Besides, VEGF concentration was significantly elevated in patients with COPD exacerbation after methylprednisolone treatment than before, and considerably higher than patients receiving the routine treatment (P<0.05).   Conclusion: AECAs may be involved in the occurrence and development of COPD and related to its severity. Methylprednisolone can help reduce AECA expression while promoting VEGF expression

Comparison of the volatiles composition between healthy and buprestid infected Juglans regia (Juglandaceae).

Meliboeus ohbayashii primoriensis (Coleoptera: Buprestidae) is an important pest of the walnut tree Juglans regia (Juglandaceae), but the volatiles mediating this plant–herbivore interaction are unknown. In this study, volatiles emitted by healthy J. regia and by plants infested with M. ohbayashii primoriensis (Coleoptera: Buprestidae) were obtained by a dynamic headspace method and analyzed by gas chromatography-mass spectrometry (Shanxi, China). We identified 26 major compounds and compared the volatile composition of healthy and buprestid-infected J. regia. Green leaf volatiles were detected in all damaged plants, including the monoterpenoids β-phellandrene and (E)-β-ocimene, the sesquiterpenoids (-)-β-bourbonene, β-ylangene, and (E,E)-α-farnesene, the alcohols linalool, myrtenol, and (E)-(-)-pinocarveol, the ketones (E)-pinocamphone and (Z)-pinocamphone, and the ester methyl salicylate. The major volatiles detected in healthy plants were β-pinene (36.26 %), α-pinene (23.81 %), D-limonene (12.03 %), sabinene (8.63 %), and β-myrcene (4.35 %). The main volatiles from M. ohbayashii primoriensis larva-infested plants were β-pinene (37.82 %), α-pinene (20.36 %), D-limonene (14.71 %), germacrene D (5.24 %), sabinene (4.52 %), and β-phellandrene (3.80 %). These results enrich our understanding of volatiles of healthy plants and plants infested with M. ohbayashii primoriensis. Furthermore, they provide a theoretical basis and scientific foundation for integrated pest management and for effective ecologically sustainable pest control strategie

AIGC Empowering Telecom Sector White Paper_chinese

In the global craze of GPT, people have deeply realized that AI, as a transformative technology and key force in economic and social development, will bring great leaps and breakthroughs to the global industry and profoundly influence the future world competition pattern. As the builder and operator of information and communication infrastructure, the telecom sector provides infrastructure support for the development of AI, and even takes the lead in the implementation of AI applications. How to enable the application of AIGC (GPT) and implement AIGC in the telecom sector are questions that telecom practitioners must ponder and answer. Through the study of GPT, a typical representative of AIGC, the authors have analyzed how GPT empowers the telecom sector in the form of scenarios, discussed the gap between the current GPT general model and telecom services, proposed for the first time a Telco Augmented Cognition capability system, provided answers to how to construct a telecom service GPT in the telecom sector, and carried out various practices. Our counterparts in the industry are expected to focus on collaborative innovation around telecom and AI, build an open and shared innovation ecosystem, promote the deep integration of AI and telecom sector, and accelerate the construction of next-generation information infrastructure, in an effort to facilitate the digital transformation of the economy and society

Nonalcoholic fatty liver associated with impairment of kidney function in nondiabetes population

Background: Nonalcoholic fatty liver disease (NAFLD) is associated with the increased burden of kidney. However, there is still no large population study to explore the potential relationship between NAFLD and mild kidney function damage (MKFD) after adjusted for confounding factors. This study is to test the hypothesis that NAFLD is associated with MKFD under controlling the effects of confoun-ding factors. Materials and methods: Levels of serum fasting glucose, creatinine, cholesterol, triglyceride, alanine aminotransferase and aspartate aminotransferase were analyzed from 1412 Chinese Han adults. Questionnaire and physical examination were performed to explore the potential association of NAFLD with kidney function. Results: NAFLD was associated with impairment of kidney function. Multivariate-adjusted odds ratio illustrated that, compared to subjects with normal liver, NAFLD subjects had a significantly higher risk of MKFD with or without adjusted for blood glucose and other covariates (P = 0.041). Further results from multi-interaction analysis demonstrated that the underlying mechanisms linked NAFLD with im-paired kidney function may be that they share common risk factors and similar pathological proces-ses. Conclusions: The most striking finding of this study is that NAFLD is negatively associated with kidney function, in nondiabetic population. NAFLD and MKFD may share similar risk factors and/or pathological processes