Methodology of teaching choreographic disciplines

Мета курсу – надання студентам магістратури цілісної і логічно-послідовної системи знань про дидактику підготовки кадрів вищої кваліфікації, розкриття концепції, основи теорії, методики і методології викладання хореографічних дисциплін у системі вищої школи.Цель курса - предоставление студентам магистратуры целостной и логически-последовательной системы знаний о дидактике подготовки кадров высшей квалификации, раскрытие концепции, основы теории, методики и методологии преподавания хореографических дисциплин в системе высшей школы.The purpose of the course is to provide undergraduate students with a coherent and logically-consistent system of knowledge about the didactics of training highly skilled personnel, the disclosure of the concept, the basis of the theory, methodology and methodology of teaching choreographic disciplines in the system of higher education

Inhibition of AR Restores the Sensitivity to Fulvestrant in ER-Positive Breast Cancer Cells

Endocrine therapy has been widely used in treating estrogen receptor (ER)-positive breast cancer which accounts for nearly 75% of breast cancer. Though endocrine therapy has shown great potency, acquired resistance occurs. Fulvestrant, the first selective ER down-regulator (SERD), was confirmed to completely suppress ERα and notably efficient. However, it has been observed that some ER-positive breast cancer would eventually develop unresponsiveness and acquired resistance to it, resulting in poor outcome. Several mechanisms have been proposed to be involved in antiestrogen resistance, such as activated pathways and altered expression of microRNAs. Of note, it is postulated androgen receptor (AR) which is often observed in most primary and metastatic breast cancer, might be a crucial protein associated with the efficacy of Fulvestrant, due to its common co-expression and intricate crosstalk with ER. In this study, we demonstrate that treatment suppressing ER would shift tumors from ER dependence to AR dependence, resulting in resistance to Fulvestrant and tumor growth. A blockade of AR could increase the sensitivity to Fulvestrant, and dual inhibition of AR and ER would be more effective than either drug alone, which might provide an insight into choosing optimal therapy for patients with AR-expressing ER-positive breast cancer. Furthermore, activated AR could also upregulate its downstream factor SOX9 to promote cell migration and proliferation

Antibacterial Activity and Physical Properties of Fish Gelatin-Chitosan Edible Films Supplemented with D-Limonene

Fish gelatin-chitosan edible films with D-limonene were successfully prepared, which exhibited exceptional mechanical properties and antimicrobial activity. It has been demonstrated that water-soluble chitosan, fish gelatin, and D-limonene could be a candidate precursor to prepare low cost and high-performance edible food packaging material. The results showed that D-limonene in the films could effectively resist the penetration of light and water because of its hydrophobicity. Moreover, the elongation at break (EAB) increased with the addition of D-limonene, which indicated that D-limonene served as a strong plasticizer for the film. Microscopic characterization showed that D-limonene was uniformly distributed in the as-prepared film. And we found that the film exhibited strong antibacterial activity against Escherichia coli (E. coli). All the results indicate that the as-prepared film could be a promising food packaging

Biofouling characteristics in Xinghua Bay of Fujian, China

Biofouling is one of the main factors affecting the efficiency and safety of cooling water systems in coastal nuclear power plants. Understanding the population dynamics, succession rules and cumulative effects of major fouling organisms is the basis for targeted prevention and control. A 1-year simulated concrete panel test was conducted from December 2020 to November 2021 in Xinghua Bay, China. A total of 78 species of fouling organisms were recorded by combining the monthly, seasonal, semiannual, annual and monthly cumulative panels, and the community composition was dominated by nearshore warm-water species, making for a typical subtropical inner bay-type community. The fouling organisms had a peak attachment period from June to October. Significantly more attachment was observed during summer (from June to August) than during the other three seasons. The attachment amount in the second half-year (from June to November) was much higher than that in the first half-year (from December to May). The attachment thickness, density, and biomass of the bottom summer panels reached 20 cm, 105,150 ind./m2, and 19,274.50 g/m2, respectively, while those of the bottom annual panels were 40 cm, 27,300 ind./m2, and 17,762.50 g/m2, respectively. The dominant fouling organisms with calcified shells mainly included Amphibalanus reticulatus and Pernaviridis. These species had high attachment amounts,could accumulate attachments for a long time, and even might cause secondary blockage, making them the most detrimental to the safety of a cooling system. Moreover,the seasonal upward growth of hydroids and bryozoans can also significantly reduce the efficiency of cooling water intake. We suggest that targeted prevention and control should be carried out according to the larval attachment period of different dominant groups of fouling organisms during June-October, which can greatly improve the prevention and control efficiency. Strengthening the research on the biological cycle phenomenon of the main species and their main environmental impact factors, and establishing a scientific and effective early-warning model are the governance direction of formulating and implementing scientific pollution prevention and control in the future

Changes of predominant species/biovars and sequence types of Brucellaisolates, Inner Mongolia, China

BACKGROUND: Human brucellosis incidence in China was divided into 3 stages, high incidence (1950-1960s), decline (1970-1980s) and re-emergence (1990-2000s). Human brucellosis has been reported in all the 32 provinces, of which Inner Mongolia has the highest prevalence, accounting for over 40% of the cases in China. To investigate the etiology alteration of human brucellosis in Inner Mongolia, the species, biovars and genotypes of 60 Brucella isolates from this province were analyzed. METHODS: Species and biovars of the Brucella strains isolated from outbreaks were determined based on classical identification procedures. Strains were genotyped by multi locus sequence typing (MLST). Sequences of 9 housekeeping genes were obtained and sequence types were defined. The distribution of species, biovars and sequence types (STs) among the three incidence stages were analyzed and compared. RESULTS: The three stages of high incidence, decline and re-emergence were predominated by B. melitensis biovar 2 and 3, B. abortus biovar 3, and B. melitensis biovar 1, respectively, implying changes in the predominant biovars. Genotyping by MLST revealed a total of 14 STs. Nine STs (from ST28 to ST36), accounting for 64.3% of all the STs, were newly defined and different from those observed in other countries. Different STs were distributed among the three stages. ST8 was the most common ST in 1950-1960s and 1990-2000s, while ST2 was the most common in 1970-1980s. CONCLUSIONS: The prevalence of biovars and sequence types of Brucella strains from Inner Mongolia has changed over time in the three stages. Compared with those from other countries, new sequence types of Brucella strains exist in China