The Impact of IT spending and Vendor Interaction on Innovation Deployment in Hospitals

This paper examines the impact of financial investment and vendor interactions on the availability of electronic health record (EHR) systems to healthcare workers and patients, which in turn impacts technology usage and hospital performance. We used hospital‐level data from the American Hospital Association (AHA) IT Supplemental Survey, the AHA Annual Survey Database, and the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey to test the EHR systems deployment model. The results show that both financial investment and vendor interactions significantly influence the availability of the HER in hospitals. Especially, collaboration with dominant vendors can lead to the high availability of the system and better performance

Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation.

The vascular endothelium is critical for induction of appropriate lineage differentiation in organogenesis. In this study, we report that dysfunctional pulmonary endothelium, resulting from the loss of matrix Gla protein (MGP), causes ectopic hepatic differentiation in the pulmonary epithelium. We demonstrate uncontrolled induction of the hepatic growth factor (HGF) caused by dysregulated cross talk between pulmonary endothelium and epithelium in Mgp-null lungs. Elevated HGF induced hepatocyte nuclear factor 4 α (Hnf4a), which competed with NK2 homeobox 1 (Nkx2.1) for binding to forkhead box A2 (Foxa2) to drive hepatic differentiation in Mgp-null airway progenitor cells. Limiting endothelial HGF reduced Hnf4a, abolished interference of Hnf4a with Foxa2, and reduced hepatic differentiation in Mgp-null lungs. Together, our results suggest that endothelial-epithelial interactions, maintained by MGP, are essential in pulmonary cell differentiation

SOX Transcription Factors in Endothelial Differentiation and Endothelial-Mesenchymal Transitions

The SRY (Sex Determining Region Y)-related HMG box of DNA binding proteins, referred to as SOX transcription factors, were first identified as critical regulators of male sex determination but are now known to play an important role in vascular development and disease. SOX7, 17, and 18 are essential in endothelial differentiation and SOX2 has emerged as an essential mediator of endothelial-mesenchymal transitions (EndMTs), a mechanism that enables the endothelium to contribute cells with abnormal cell differentiation to vascular disease such as calcific vasculopathy. In the following paper, we review published information on the SOX transcription factors in endothelial differentiation and hypothesize that SOX2 acts as a mediator of EndMTs that contribute to vascular calcification

Noggin depletion in adipocytes promotes obesity in mice.

ObjectiveObesity has increased to pandemic levels and enhanced understanding of adipose regulation is required for new treatment strategies. Although bone morphogenetic proteins (BMPs) influence adipogenesis, the effect of BMP antagonists such as Noggin is largely unknown. The aim of the study was to define the role of Noggin, an extracellular BMP inhibitor, in adipogenesis.MethodsWe generated adipose-derived progenitor cells and a mouse model with adipocyte-specific Noggin deletion using the AdiponectinCre transgenic mouse, and determined the adipose phenotype of Noggin-deficiency.ResultsOur studies showed that Noggin is expressed in progenitor cells but declines in adipocytes, possibly allowing for lipid accumulation. Correspondingly, adipocyte-specific Noggin deletion in vivo promoted age-related obesity in both genders with no change in food intake. Although the loss of Noggin caused white adipose tissue hypertrophy, and whitening and impaired function in brown adipose tissue in both genders, there were clear gender differences with the females being most affected. The females had suppressed expression of brown adipose markers and thermogenic genes including peroxisome proliferator activated receptor gamma coactivator 1 alpha (PGC1alpha) and uncoupling protein 1 (UCP1) as well as genes associated with adipogenesis and lipid metabolism. The males, on the other hand, had early changes in a few BAT markers and thermogenic genes, but the main changes were in the genes associated with adipogenesis and lipid metabolism. Further characterization revealed that both genders had reductions in VO2, VCO2, and RER, whereas females also had reduced heat production. Noggin was also reduced in diet-induced obesity in inbred mice consistent with the obesity phenotype of the Noggin-deficient mice.ConclusionsBMP signaling regulates female and male adipogenesis through different metabolic pathways. Modulation of adipose tissue metabolism by select BMP antagonists may be a strategy for long-term regulation of age-related weight gain and obesity

Effect of Two Kinds of Bone Replacement Materials on Bone Formation in Repairing Bone Defects Around Mandibular Posterior Area: a Case Study of Bone Defects Around Mandibular Posterior Area Caused by Boxing

Objective: To investigate the effect of two kinds of bone replacement materials on bone formation in repairing bone defect around mandibular posterior area. Methods: A total of 60 patients with Bone defects around mandibular posterior area caused by boxing were selected from a hospital from January 2020 to June 2020. They were divided into Perio Glas (group P) and Bone Plant (group B) by random number table method, with 30 patients in each group. Perio Glas Bone graft was used in group P and Bone Plant graft was used in group B. The vertical height and buccal lingual bone plate width of the two groups were observed at baseline and after treatment, and the success rate of implants was compared between the two groups. Results: The success rate of implant in group P was significantly lower than that in group B (P < 0.05). The vertical height and buccal lingual bone plate width in group P were significantly lower than those in group B (P < 0.05). Conclusion: Compared with Perio Glas, Bone Plant can better maintain the vertical height and buccal lingual Bone plate width of patients with Bone defects around mandibular posterior area caused by boxing, and has better effect of inducing Bone regeneration and osteogenesis

Application of Nanotechnology in Oral Implantation Based on Exercise-Induced Tooth Injury

With the development of sports in various countries, more and more people participate in sports, and the rate of sports injuries to the oral and maxillofacial system also increases, especially the dental injuries caused by boxing are more common. At the same time, with the improvement of modern production, people's basic needs have been continuously met, and more and more people have begun to pay attention to their physical health and appearance characteristics. Among them, dental plastic correction and restoration have received great attention. In addition, with the application of nanotechnology in various fields in recent years, scholars at home and abroad have also tried or have continued to introduce nanomaterials into oral clinics, in order to improve and develop the application of oral materials, so that the oral clinic can be continuously improved and developed. Therefore, this paper reviews the current situation of sports injury of the oral and maxillofacial system, the mechanical analysis of tooth injury, the current situation of tooth restoration and the application of nanotechnology in the field of oral implantation

Effect of Two Kinds of Bone Replacement Materials on Bone Formation in Repairing Bone Defects around Mandibular Posterior Area: A Case Study of Bone Defects around Mandibular Posterior Area Caused by Boxing

Objective: To investigate the effect of two kinds of bone replacement materials on bone formation in repairing bone defect around mandibular posterior area. Methods: A total of 60 patients with Bone defects around mandibular posterior area caused by boxing were selected from a hospital from January 2020 to June 2020. They were divided into Perio Glas (group P) and Bone Plant (group B) by random number table method, with 30 patients in each group. Perio Glas Bone graft was used in group P and Bone Plant graft was used in group B. The vertical height and buccal lingual bone plate width of the two groups were observed at baseline and after treatment, and the success rate of implants was compared between the two groups. Results: The success rate of implant in group P was significantly lower than that in group B (P < 0.05). The vertical height and buccal lingual bone plate width in group P were significantly lower than those in group B (P < 0.05). Conclusion: Compared with Perio Glas, Bone Plant can better maintain the vertical height and buccal lingual Bone plate width of patients with Bone defects around mandibular posterior area caused by boxing, and has better effect of inducing Bone regeneration and osteogenesis