Unravelling the Carbon Emissions Compliance in Sustainable Supply Chains: The Impacts of Carbon Audit Cooperation

As one of the 17 Sustainable Development Goals, reducing carbon emissions is crucial to combat climate change. It has also prompted companies to comply with emission regulations and evaluate the environmental impacts of their supply chains. Yet, news and reports occasionally highlight industrial instances of noncompliance. In particular, supplier's noncompliance is often mistakenly attributed to its downstream manufacturers. Due to this misconception, manufacturers might conduct audits to protect their reputation and sales. Moreover, because a supplier may provide components to multiple competing manufacturers, they may collaborate to share audit findings regarding the common supplier's compliance with carbon emissions regulations. However, studies do not reveal how this audit cooperation affects stakeholder interests. Here, we introduce a stylised model to examine the effects of carbon audit cooperation on the environment , competing manufacturers, and their supplier. We identify two main effects: the free-riding and amplifying effects. The former benefits the supplier but harms the environment and competing manufacturers, while the latter presents the opposite effect. The net impact depends on the balance between these two effects, which challenges conventional beliefs about carbon emissions compliance and highlights the importance of sustainability in the industry. Finally, we explore various extensions to validate the robustness of our findings

Pregnancy‐related knowledge in women with epilepsy in childbearing age: A pilot questionnaire survey from China

Abstract Purpose We aim to understand the knowledge of and attitudes toward pregnancy issues among women with epilepsy (WWE) and their caregivers and analyze the answers from the questionnaire to expose topics that require educational activities; thus, WWE experiences pregnancy better. Methods WWE at their childbearing age and/or their caregivers who entered the Fourth Affiliated Hospital of Zhejiang University for treatment of their condition were invited to fill out a questionnaire between March 1 and November 31, 2022. Results A combined total of 205 WWE and 142 caregivers completed the questionnaires. Among the surveyed WWE, a majority (63.74%) reported experiencing at least one miscarriage or induced abortion. However, a significant proportion (84.62%) of these WWE were still able to successfully give birth to at least one child. Furthermore, the offspring of these WWE showed no significant differences compared to the offspring of women without epilepsy, as reported by 93.51% of the participants. The participants’ knowledge regarding the impact of epilepsy on pregnancy was found to be comparable, with average scores of 7.74 and 7.84, respectively. The participants exhibited a limited comprehension of antiseizure medications (ASMs)‐related knowledge, specifically pertaining to ASMs adjustment during pregnancy (17.56% vs. 16.90%) and offspring outcomes (30.24% vs. 26.06%). Statistical analysis revealed significant correlations between the overall score and education level (p < .001), as well as epilepsy duration (p = .008). Regarding the source of knowledge, participants acknowledged primarily relying on neurologists, who remained their preferred choice for consultation. Conclusion In our study, the understanding of pregnancy‐related knowledge did not differ from WWE and their caregivers, both are far from satisfactory in certain areas. It is urgent for WWE and their caregivers to improve their pregnancy‐related knowledge of epilepsy. As their primary access is from knowledgeable health care professionals like neurologists, well‐trained neurologists in epilepsy management during pregnancy are in need

Epistatic Association of CD14 and NOTCH2 Genetic Polymorphisms with Biliary Atresia in a Southern Chinese Population

Biliary atresia (BA) is the most common cause of endstage liver disease in infants with poor prognosis and high mortality. The etiology of BA is still unknown, but the genetic factors have been considered as an important player in BA. We investigated the association of two cis-regulated variants in CD14 (rs2569190) and NOTCH2 (rs835576) with BA susceptibility, using the largest case-control cohort, totaling 506 BA patients and 1,473 healthy controls in a Southern Chinese population. Significant epistatic interaction between the two variants in our samples was observed (p = 8.1E−03; OR = 2.78; 95% CI: 1.32–5.88). The expression of CD14 and NOTCH2 in the BA group was consistently lower than that in the control (CC) group (0.31 ± 0.02 versus 1.00 ± 0.14; p < 0.001), which might be related to the genetic susceptibility of the genes awaiting further validation. Keywords: CD14, Notch2, biliary atresia, epistasi

Additional file 1 of Intranasal delivery of phenytoin loaded layered double hydroxide nanoparticles improves therapeutic effect on epileptic seizures

Supplementary Material