107 research outputs found
Total Antioxidant Capacity and Polyphenol Content Correlation in Aqueous-Alcoholic Plant Extracts Used in Phytotherapy
The present investigation analyzes the antioxidant properties of aqueous-alcoholic extracts of Bulgarian plants used in phytotherapy in relation with their polyphenol content.Β The total phenolic (TP) content and total antioxidant capacity (TAC) values of aqueous-alcoholic extract from Hypericum perforatum, Cydonia vulgaris, Arcostaphylos uva-ursi and Cotinus coggygria significantly exceeded the TP and TAC values of Ilex paraguariensis (mate), Aspalathus linearis (rooibos), Cyclopia intermedia (honeybush), and Camellia sinensis (black tea), famous for their antioxidants' content. The high degree of positive correlation (r=0,91) between TAC and TP values indicates the role of polyphenols for the plant antioxidant potential. Bulgarian medicinal plants are excellent sources of antioxidants established by their high TAC values as compared to the famous foreign plants honeybush, rooibos, mate and black tea and they prove to be a potential for the development of new pharmaceutical
Mitochondrial DNA Suggests a Western Eurasian origin for Ancient (Proto-) Bulgarians
Ancient (proto-) Bulgarians have long been thought to as a Turkic population. However, evidence found in the past three decades show that this is not the case. Until now, this evidence does not include ancient mitochondrial DNA (mtDNA) analysis. In order to fill this void, we have collected human remains from the VIII-X century AD located in three necropolises in Bulgaria: Nojarevo (Silistra region) and Monastery of Mostich (Shumen region), both in Northeast Bulgaria and Tuhovishte (Satovcha region) in Southwest Bulgaria. The phylogenetic analysis of 13 ancient DNA samples (extracted from teeth) identified 12 independent haplotypes, which we further classified into mtDNA haplogroups found in present-day European and Western Eurasian populations. Our results suggest a Western Eurasian matrilineal origin for proto-Bulgarians as well as a genetic similarity between proto- and modern Bulgarians. Our future work will provide additional data which will further clarify proto-Bulgarian origins; thereby adding new clues to current understanding of European genetic evolution
Predictive factors for the development of post-operative fibrinous exudation
ΠΡΡΠΊΠ° Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ½Π° ΠΏΡΠΎΡΠ΅Π΄ΡΡΠ° Π² ΠΎΡΡΠ°Π»ΠΌΠΎΠ»ΠΎΠ³ΠΈΡΡΠ° Π΅ ΠΏΡΠ΅Π΄ΠΌΠ΅Ρ Π½Π° Π΄Π΅Π±Π°Ρ, ΠΎΡΠ½ΠΎΡΠ½ΠΎ ΡΠ²ΠΎΠΈΡΠ΅ ΠΏΡΠΈΠ»ΠΎΠΆΠ΅Π½ΠΈΡ, Π΅ΡΠΈΠΊΠ°ΡΠ½ΠΎΡΡ, ΡΠΈΡΠΊΠΎΠ²ΠΈ ΡΠ°ΠΊΡΠΎΡΠΈ, ΠΏΡΠΎΡΠΈΠ²ΠΈΠΏΠΎΠΊΠ°Π·Π°Π½ΠΈΡ ΠΈ Π΄Ρ. ΠΠ°Π»ΠΈΡΠ΅ Π΅ ΠΎΠ±Π°ΡΠ΅ Π½Π΅Π΄ΠΈΡΠΊΡΡΠΈΡΡΠ΅ΠΌ ΠΈ Π½Π΅ΠΏΡΠ΅Ρ
ΠΎΠ΄Π΅Π½ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΡ Π·Π° ΡΠΎΠ²Π°, ΡΠ΅ ΠΏΠΎΡΡΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΡΠΎ Π²ΡΠ·ΠΏΠ°Π»Π΅Π½ΠΈΠ΅ ΡΠ»Π΅Π΄ Π²ΡΡΠΊΠ° Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ½Π° ΠΈΠ½ΡΠ΅ΡΠ²Π΅Π½ΡΠΈΡ ΡΡΡΠ±Π²Π° Π΄Π° Π±ΡΠ΄Π΅ ΠΌΠΈΠ½ΠΈΠΌΠ°Π»Π½ΠΎ1. Π§Π΅ΡΡΠΎΡΠ°ΡΠ° Π½Π° Π²ΡΠ·ΠΏΠ°Π»ΠΈΡΠ΅Π»Π½Π°ΡΠ° ΡΠ΅Π°ΠΊΡΠΈΡ Π² ΠΏΡΠ΅Π΄Π½Π°ΡΠ° ΠΊΠ°ΠΌΠ΅ΡΠ° ΡΠ»Π΅Π΄ ΠΊΠ°ΡΠ°ΡΠ°ΠΊΡΠ½Π° Ρ
ΠΈΡΡΡΠ³ΠΈΡ ΠΌΠΎΠΆΠ΅ Π΄Π° Π΄ΠΎΡΡΠΈΠ³Π½Π΅ Π΄ΠΎ 30%, Π²Π°ΡΠΈΡΠ°ΠΉΠΊΠΈ ΠΏΠΎ ΡΠ΅ΠΆΠ΅ΡΡ2. ΠΡΠ΅Π΄Π½ΠΎΠΊΠ°ΠΌΠ΅ΡΠ½Π°ΡΠ° Π²ΡΠ·ΠΏΠ°Π»ΠΈΡΠ΅Π»Π½Π° ΡΠ΅Π°ΠΊΡΠΈΡ Π΅ ΡΠΈΠ³Π½ΠΈΡΠΈΠΊΠ°Π½ΡΠ° ΠΏΠΎΡΠ°Π΄ΠΈ ΡΠ°ΠΊΡΠ°, ΡΠ΅ ΠΌΠΎΠΆΠ΅ Π΄Π° Π΄ΠΎΠ²Π΅Π΄Π΅ Π΄ΠΎ ΠΏΠΎΠ²ΠΈΡΠ°Π²Π°Π½Π΅ Π½Π° Π²ΡΡΡΠ΅ΠΎΡΠ½ΠΎΡΠΎ Π½Π°Π»ΡΠ³Π°Π½Π΅ (ΠΠΠ), ΠΊΠΎΡΠ½Π΅Π°Π»Π΅Π½ Π΅Π΄Π΅ΠΌ, Π΅Π½Π΄ΠΎΡΠ΅Π»Π½Π° ΡΠ²ΡΠ΅Π΄Π°, ΡΠΈΠ±ΡΠΈΠ½ΠΎΠ²Π° Π΅ΠΊΡΡΠ΄Π°ΡΠΈΡ ΠΈ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π° Π² ΠΏΡΠ΅Π΄Π½Π°ΡΠ° ΠΎΡΠ½Π° ΠΊΠ°ΠΌΠ΅ΡΠ°, Π·Π°Π΄Π½ΠΈ ΡΠΈΠ½Π΅Ρ
ΠΈΠΈ, ΠΊΠΈΡΡΠΎΠΈΠ΄Π΅Π½ ΠΌΠ°ΠΊΡΠ»Π΅ΠΈ ΠΎΡΠΎΠΊ, Ρ
ΡΠΎΠ½ΠΈΡΠ΅Π½ ΠΏΡΠ΅Π΄Π΅Π½ ΡΠ²Π΅ΠΈΡ ΠΈ Π΄Ρ. ΠΠ·ΡΠ»Π΅Π΄Π²Π°Π½Π΅ ΠΈ Π°Π½Π°Π»ΠΈΠ· Π½Π° ΡΠ°Π·Π»ΠΈΡΠ½ΠΈ ΡΠ°ΠΊΡΠΎΡΠΈ, ΠΊΠΎΠΈΡΠΎ ΠΎΠΊΠ°Π·Π²Π°Ρ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π²ΡΡΡ
Ρ ΡΠΈΠ±ΡΠΈΠ½ΠΎΠ²Π°ΡΠ° ΠΏΡΠ΅Π΄Π½ΠΎΠΊΠ°ΠΌΠ΅ΡΠ½Π° Π΅ΠΊΡΡΠ΄Π°ΡΠΈΡ, Π±ΠΈΡ
Π° ΠΏΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ Π½ΠΎΠ²ΠΈ Π²ΡΠΏΡΠΎΡΠΈ Π·Π° Π΄ΠΈΡΠΊΡΡΠΈΡ, ΠΎΡΠ½ΠΎΡΠ½ΠΎ ΠΏΡΠ΅Π΄- , ΠΈΠ½ΡΡΠ°- ΠΈ ΠΏΠΎΡΡΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΈΡ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅Π½ Π°Π»Π³ΠΎΡΠΈΡΡΠΌ.Π¦Π΅Π»ΠΠ° ΠΈΠ·ΡΠ»Π΅Π΄Π²Π°ΠΌΠ΅ ΠΈ Π°Π½Π°Π»ΠΈΠ·ΠΈΡΠ°ΠΌΠ΅ ΡΠ°Π·Π»ΠΈΡΠ½ΠΈ ΡΠ°ΠΊΡΠΎΡΠΈ, ΠΊΠΎΠΈΡΠΎ Π±ΠΈΡ
Π° ΠΌΠΎΠ³Π»ΠΈ Π΄Π° Π±ΡΠ΄Π°Ρ Π² ΠΊΠΎΡΠ΅Π»Π°ΡΠΈΠΎΠ½Π½ΠΈ Π²Π·Π°ΠΈΠΌΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΡΠΎ Π½Π° ΡΠΈΠ±ΡΠΈΠ½ΠΎΠ²Π° ΡΠ΅Π°ΠΊΡΠΈΡ Π² ΠΏΡΠ΅Π΄Π½Π°ΡΠ° ΠΎΡΠ½Π° ΠΊΠ°ΠΌΠ΅ΡΠ° ΡΠ»Π΅Π΄ ΡΠ°ΠΊΠΎΠ΅ΠΌΡΠ»ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½Π° Ρ
ΠΈΡΡΡΠ³ΠΈΡ. ΠΠ° ΠΏΡΠ΅Π΄ΡΡΠ°Π²ΠΈΠΌ, ΡΡΡΠΎ ΡΠ°ΠΊΠ°, Π½Π°ΡΠΈΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅Π½ ΠΎΠΏΠΈΡ Π² ΡΠ΅ΡΠ°ΠΏΠΈΡΡΠ° Π½Π° ΠΎΡΡΡΠΎ Π½Π°ΡΡΡΠΏΠΈΠ»Π°ΡΠ° ΡΠΈΠ±ΡΠΈΠ½ΠΎΠ²Π° Π΅ΠΊΡΡΠ΄Π°ΡΠΈΡ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΠΈΠ·Π°ΠΉΠ½ΡΡ Π½Π° Π½Π°ΡΡΠΎΡΡΠ΅ΡΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ½ΠΎ ΠΏΡΠΎΡΡΠ²Π°Π½Π΅ Π΅ ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π΅Π½ ΠΈ ΠΎΠ±ΡΠ΅ΡΠ²Π°ΡΠΈΠΎΠ½Π΅Π½, Ρ ΠΏΠ΅ΡΠΈΠΎΠ΄ Π½Π° ΠΏΡΠΎΡΠ»Π΅Π΄ΡΠ²Π°Π½Π΅ 04.01 - 15.12.2017r. ΠΡΠΈΡΠ΅ΡΠΈΠΈΡΠ΅ Π·Π° Π²ΠΊΠ»ΡΡΠ²Π°Π½Π΅ Π² ΠΈΠ·ΡΠ»Π΅Π΄Π²Π°Π½Π΅ΡΠΎ ΡΠ° ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΠΎ ΠΏΡΠΎΡΠ΅ΠΊΠ»Π° ΡΠ°ΠΊΠΎΠ΅ΠΌΡΠ»ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ Π½Π° Π»Π΅ΡΠ°, Π±Π΅Π· ΠΈΠ½ΡΡΠ°ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΈ ΠΊΠΎΠΌΠΏΠ»ΠΈΠΊΠ°ΡΠΈΠΈ ΠΈ ΠΈΠΌΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡ Π½Π° ΠΠΠ Π² ΠΊΠ°ΠΏΡΡΠ»Π½ΠΈΡ ΡΠ°ΠΊ.ΠΠ·ΠΊΠ»ΡΡΠ²Π°ΡΠΈΡΠ΅ ΠΊΡΠΈΡΠ΅ΡΠΈΠΈ, ΠΊΠΎΠΈΡΠΎ ΡΠ΅ Π²Π·Π΅Ρ
Π° ΠΏΡΠ΅Π΄Π²ΠΈΠ΄, Ρ ΡΠ΅Π» ΠΎΠ±ΠΎΡΠΎΠ±ΡΠ²Π°Π½Π΅ Π½Π° ΡΠΈΡΠΊΠΎΠ²ΠΈΡΠ΅ ΡΠ°ΠΊΡΠΎΡΠΈ ΡΠ°ΠΌΠΎ Π·Π° ΡΠ°ΠΊΠΎΠ΅ΠΌΡΠ»ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡΡΠ° ΠΊΠ°ΡΠΎ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅Π½ ΠΌΠ΅ΡΠΎΠ΄, ΡΠ° ΠΈΠ·Π²ΡΡΡΠ²Π°Π½Π΅ Π½Π° Π΅Π΄Π½ΠΎΠ΅ΡΠ°ΠΏΠ½Π°, ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠ°Π½Π° Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ½Π° ΠΏΡΠΎΡΠ΅Π΄ΡΡΠ° (ΡΠ°ΠΊΠΎΠ΅ΠΌΡΠ»ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ Ρ ΡΡΠ°Π±Π΅ΠΊΡΠ»Π΅ΠΊΡΠΎΠΌΠΈΡ, ΡΠ°ΠΊΠΎΠ΅ΠΌΡΠ»ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ Ρ ΠΏΠ°ΡΡ ΠΏΠ»Π°Π½Π° Π²ΠΈΡΡΠ΅ΠΊΡΠΎΠΌΠΈΡ).ΠΠ·Π²ΡΡΡΠ΅Π½ΠΈΡΡ ΠΏΡΠ΅Π΄ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π΅Π½ Π½Π°Π±ΠΎΡ ΠΈΠ·ΡΠ»Π΅Π΄Π²Π°Π½ΠΈΡ Π²ΠΊΠ»ΡΡΠ²Π° ΠΎΠ±ΡΡΠΎΠΉΠ½ΠΎ ΠΎΡΡΠ°Π»ΠΌΠΎΠ»ΠΎΠ³ΠΈΡΠ½ΠΎ ΠΈΠ·ΡΠ»Π΅Π΄Π²Π°Π½Π΅, ΠΈΠ½Π΄ΠΈΡΠ΅ΠΊΡΠ½Π° ΠΎΡΡΠ°Π»ΠΌΠΎΡΠΊΠΎΠΏΠΈΡ, Goldmann ΡΠΎΠ½ΠΎΠΌΠ΅ΡΡΠΈΡ, ΠΊΠ΅ΡΠ°ΡΠΎΠΌΠ΅ΡΡΠΈΡ ΠΈ Π±ΠΈΠΎΠΌΠ΅ΡΡΠΈΡΠ½Π°, ΡΠ»ΡΡΠ°Π·Π²ΡΠΊΠΎΠ²Π° Π Π΅Ρ
ΠΎΠ³ΡΠ°ΡΠΈΡ.ΠΠ° Π²ΡΠΈΡΠΊΠΈ 191 ΡΡΠ°ΡΡΠ½ΠΈΡΠΈ Π² ΠΈΠ·ΡΠ»Π΅Π΄Π²Π°Π½Π΅ΡΠΎ, ΠΎΡ ΠΊΠΎΠΈΡΠΎ 67 ΠΌΡΠΆΠ΅ (35,1 %) ΠΈ 124 ΠΆΠ΅Π½ΠΈ (64,9%), Π½Π° ΡΡΠ΅Π΄Π½Π° Π²ΡΠ·ΡΠ°ΡΡ ~ 68Π³., Π² ΠΏΠ»Π°Π½ΠΎΠ² ΠΏΠΎΡΡΠ΄ΡΠΊ, Π΅ ΠΈΠ·Π²ΡΡΡΠ΅Π½Π° ΡΠ°ΠΊΠΎΠ΅ΠΌΡΠ»ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ Π½Π° Π»Π΅ΡΠ° Ρ ΠΈΠΌΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡ Π½Π° Π²ΡΡΡΠ΅ΠΎΡΠ½Π° ΠΈΠ·ΠΊΡΡΡΠ²Π΅Π½Π° Π»Π΅ΡΠ° (ΠΠΠ). ΠΡΠΈΡΠΊΠΈ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ ΡΠ° ΠΈΠ·Π²ΡΡΡΠ΅Π½ΠΈ Π² 3ΡΠΎ ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ Π½Π° ΠΠ»ΠΈΠ½ΠΈΠΊΠ°ΡΠ° ΠΏΠΎ ΠΎΡΠ½ΠΈ Π±ΠΎΠ»Π΅ΡΡΠΈ, Π£ΠΠΠΠ "ΠΠ»Π΅ΠΊΡΠ°Π½Π΄ΡΠΎΠ²ΡΠΊΠ°", ΠΎΡ Π΅Π΄ΠΈΠ½ Ρ
ΠΈΡΡΡΠ³, ΠΏΠΎ Π΅Π΄Π½Π° ΠΈ ΡΡΡΠ°, ΡΡΠ²ΡΡΠ΄Π΅Π½Π° Π² ΠΊΠ»ΠΈΠ½ΠΈΠΊΠ°ΡΠ°, ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠ°.Π Π΅Π·ΡΠ»ΡΠ°ΡΠΈΠΠ° Π²ΡΠΈΡΠΊΠΈ 191 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° (191 ΠΎΡΠΈ) Π΅ ΠΈΠ·Π²ΡΡΡΠ΅Π½Π° ΡΠ°ΠΊΠΎΠ΅ΠΌΡΠ»ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ Π½Π° Π»Π΅ΡΠ° Ρ ΠΈΠΌΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡ Π½Π° ΠΠΠ, ΠΏΠΎ ΡΡΠ²ΡΡΠ΄Π΅Π½Π° Π² ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ΡΠΎ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠ°, Π±Π΅Π· ΠΊΠΎΠΌΠΏΠ»ΠΈΠΊΠ°ΡΠΈΠΈ. 78 (40,8%) ΠΎΡ ΡΡΠ°ΡΡΠ½ΠΈΡΠΈΡΠ΅ ΡΠ° Ρ Ρ
ΠΈΠ΄ΡΠΎΡΠΎΠ±Π΅Π½, Π°ΠΊΡΠΈΠ»Π΅Π½, Π°ΡΡΠ΅ΡΠΈΡΠ΅Π½ ΠΈΠΌΠΏΠ»Π°Π½Ρ, Π΄ΠΎΠΊΠ°ΡΠΎ ΠΎΡΡΠ°Π½Π°Π»Π°ΡΠ° Π³ΡΡΠΏΠ° ΠΎΡ 113 Π΄ΡΡΠΈ (59,2%) ΡΠ° Ρ Ρ
ΠΈΠ΄ΡΠΎΡΠΈΠ»Π΅Π½, Π°ΠΊΡΠΈΠ»Π΅Π½, Π°ΡΡΠ΅ΡΠΈΡΠ΅Π½ Π²Π°ΡΠΈΠ°Π½Ρ Π½Π° ΠΠΠ. ΠΠ°ΡΠΈΠ΅Π½ΡΠΈΡΠ΅ Ρ ΠΊΠΎΠ½Π²Π΅Π½ΡΠΈΠΎΠ½Π°Π»Π½Π° ΠΌΠΎΠ½ΠΎΡΠΎΠΊΠ°Π»Π½Π° ( Ρ
ΠΈΠ΄ΡΠΎΡΠΈΠ»Π½Π° ΠΈ Ρ
ΠΈΠ΄ΡΠΎΡΠΎΠ±Π½Π°) ΠΠΠ ΡΠ° 162 (84,8%), a ΠΏΡΠΈ 29 (15,2%) Π΅ ΠΈΠΌΠΏΠ»Π°Π½ΡΠΈΡΠ°Π½Π° Ρ
ΠΈΠ΄ΡΠΎΡΠΈΠ»Π½Π° ΠΠΠ Ρ ΡΠ°Π·ΡΠΈΡΠ΅Π½Π° Π΄ΡΠ»Π±ΠΎΡΠΈΠ½Π° Π½Π° ΡΠΎΠΊΡΡΠ° (EDOF). Π€ΠΈΠ±ΡΠΈΠ½ΠΎΠ²Π° Π΅ΠΊΡΡΠ΄Π°ΡΠΈΡ Π² ΠΏΡΠ΅Π΄Π½Π°ΡΠ° ΠΎΡΠ½Π° ΠΊΠ°ΠΌΠ΅ΡΠ° (ΠΠ), ΠΏΡΠ΅Π· ΡΠ°Π½Π½ΠΈΡ ΠΏΠΎΡΡΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π΅Π½ ΠΏΠ΅ΡΠΈΠΎΠ΄, Π΅ ΡΡΡΠ°Π½ΠΎΠ²Π΅Π½Π° ΠΏΡΠΈ ΠΏΠ΅Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° (2,4%) ΠΎΡ ΠΈΠ·ΡΠ»Π΅Π΄Π²Π°Π½Π°ΡΠ° ΠΊΠΎΡ
ΠΎΡΡΠ°. Π‘Π»Π΅Π΄ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π° Π»ΠΎΠΊΠ°Π»Π½Π° ΡΠ΅ΡΠ°ΠΏΠΈΡ Ρ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΡΠ·ΠΏΠ°Π»ΠΈΡΠ΅Π»Π½ΠΈ ΡΡΠ΅Π΄ΡΡΠ²Π° (ΠΊΠΎΡΡΠΈΠΊΠΎΡΡΠ΅ΡΠΎΠΈΠ΄ΠΈ) ΡΠΈΠ±ΡΠΈΠ½ΠΎΠ²Π°ΡΠ° ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π° ΠΏΡΠΈ Π²ΡΠ΅ΠΊΠΈ ΠΎΡ ΠΏΠ΅ΡΡΠ΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° ΡΠ΅ ΡΠ΅Π·ΠΎΡΠ±ΠΈΡΠ° Π½Π°ΠΏΡΠ»Π½ΠΎ. ΠΡΡΠ΅ΡΠ΅Π½ΠΎ Π±Π΅, ΡΠ΅ Π½Π°Π»ΠΈΡΠΈΠ΅ΡΠΎ Π½Π° Π·Π°Ρ
Π°ΡΠ΅Π½ Π΄ΠΈΠ°Π±Π΅Ρ (80% ΠΎΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΈΡΠ΅ Ρ Π΅ΠΊΡΡΠ΄Π°ΡΠΈΡ), ΠΊΠ°ΡΠΎ ΠΏΡΠΈΠ΄ΡΡΠΆΠ°Π²Π°ΡΠΎ Π·Π°Π±ΠΎΠ»ΡΠ²Π°Π½Π΅, ΠΈ ΠΈΠΌΠΏΠ»Π°Π½ΡΠ°ΡΠΈΡΡΠ° Π½Π° ΠΌΠΎΠ½ΠΎΡΠΎΠΊΠ°Π»Π½Π° Ρ
ΠΈΠ΄ΡΠΎΡΠΈΠ»Π½Π° ΠΠΠ (1 ΠΠ% ΠΎΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΈΡΠ΅ Ρ Π΅ΠΊΡΡΠ΄Π°ΡΠΈΡ) ΡΠ° ΡΠ°ΠΊΡΠΎΡΠΈΡΠ΅ Ρ Π½Π°ΠΉ-Π²ΠΈΡΠΎΠΊΠ° ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΈΠ²Π½Π° ΡΡΠΎΠΉΠ½ΠΎΡΡ Π·Π° ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ Π½Π° ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ½Π° ΡΠΈΠ±ΡΠΈΠ½ΠΎΠ²Π° ΡΠ΅Π°ΠΊΡΠΈΡ.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅Π‘ΡΠ°ΡΡΠ΅ΡΠΊΠ°ΡΠ° ΠΊΠ°ΡΠ°ΡΠ°ΠΊΡΠ° Π΅ ΡΡΠ΅Π΄ ΠΎΡΠ½ΠΎΠ²Π½ΠΈΡΠ΅ Π²ΡΠ·ΡΠ°ΡΡΠΎΠ²ΠΎ-ΡΠ²ΡΡΠ·Π°Π½ΠΈ ΠΎΡΠ½ΠΈ Π·Π°Π±ΠΎΠ»ΡΠ²Π°Π½ΠΈΡ. ΠΠ΅ΠΉΠ½Π°ΡΠ° ΡΠ΅ΡΡΠΎΡΠ° Π½Π°ΡΠ°ΡΡΠ²Π° Ρ Π½Π°ΠΏΡΠ΅Π΄Π²Π°Π½Π΅ Π½Π° Π²ΡΠ·ΡΠ°ΡΡΡΠ° 3. Π Π½Π°ΡΠΈΠΎΠ½Π°Π»Π΅Π½ ΠΈ ΡΠ²Π΅ΡΠΎΠ²Π΅Π½ ΠΌΠ°ΡΠ°Π± ΡΠ°ΠΊΠΎΠ΅ΠΌΡΠ»ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡΡΠ° Π΅ Π½Π°ΠΉ-ΡΠ΅ΡΡΠΎ ΠΈΠ·Π²ΡΡΡΠ²Π°Π½Π°ΡΠ° Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ½Π° ΠΈΠ½ΡΠ΅ΡΠ²Π΅Π½ΡΠΈΡ Π² ΠΎΡΡΠ°Π»ΠΌΠΎΠ»ΠΎΠ³ΠΈΡΡΠ° 4. Π Π°Π·Π½ΠΎΠΎΠ±ΡΠ°Π·ΠΈΠ΅ΡΠΎ Π½Π° Π²ΠΈΠ΄ΠΎΠ²Π΅ΡΠ΅ Π²ΡΡΡΠ΅ΠΎΡΠ½ΠΈ ΠΈΠ·ΠΊΡΡΡΠ²Π΅Π½ΠΈ Π»Π΅ΡΠΈ Π² Π΄Π½Π΅ΡΠ½ΠΎ Π²ΡΠ΅ΠΌΠ΅ Π΅ ΠΎΠ³ΡΠΎΠΌΠ½ΠΎ, ΠΎΠΏΠΈΡΠ²Π°ΠΉΠΊΠΈ ΡΠ΅ Π΄Π° Π·Π°Π΄ΠΎΠ²ΠΎΠ»ΠΈ ΠΏΠΎΡΡΠΎΡΠ½Π½ΠΎ ΠΏΠΎΠ²ΠΈΡΠ°Π²Π°ΡΠΈΡΠ΅ ΡΠ΅ ΠΈΠ·ΠΈΡΠΊΠ²Π°Π½ΠΈΡ ΠΈ ΡΡΠ°Π½Π΄Π°ΡΡΠΈ Π² ΠΎΡΡΠ°Π»ΠΌΠΎΡ
ΠΈΡΡΡΠ³ΠΈΡΡΠ°. ΠΠΎΠΊΠ°ΡΠ²Π°ΡΠ°ΡΠ° ΡΠ΅ ΡΠ΅ΡΡΠΎΡΠ°ΡΠ° Π½Π° Π·Π°Ρ
Π°ΡΠ½ΠΈΡ Π΄ΠΈΠ°Π±Π΅Ρ ΠΏΠΎΡΡΠ°Π²Ρ Π½ΠΎΠ²ΠΈ ΠΈ Π²Π°ΠΆΠ½ΠΈ Π²ΡΠΏΡΠΎΡΠΈ ΠΎΡΠ½ΠΎΡΠ½ΠΎ ΠΊΠΎΠΉ ΡΠΈΠΏ ΠΠΠ ΡΠ° Π½Π°ΠΉ-ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΡΡΠΈ ΠΈ ΠΏΡΠ΅ΠΏΠΎΡΡΡΠΈΡΠ΅Π»Π½ΠΈ ΠΏΡΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΈΡΠ΅ ΡΡΡ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΈ ΠΏΡΠΈΠ΄ΡΡΠΆΠ°Π²Π°ΡΠΈ Π·Π°Π±ΠΎΠ»ΡΠ²Π°Π½ΠΈΡ.IntroductionEach surgical procedure in ophthalmology is a subject of debate about its applications, efficiency, risk factors, contraindications, etc. There is, however, an indiscriminate and persistent consensus that post-operative inflammation after each surgical intervention should be minimal. The incidence of inflammation in the anterior chamber after cataract surgery may reach 30%, varying in severity. The anterior chamber inflammatory response is significant due to the fact that it can lead to elevated intraocular pressure (IOP), corneal edema, endothelial damage, fibrinous exudation and membrane in the anterior chamber, posterior synechiae, cystoid macular edema, chronic anterior uveitis and others. Investigation and analysis of various factors influencing fibrinous pre-chamber exudation would pose new questions for discussion about the pre-, intra- and postoperative therapeutic algorithm.AimTo investigate and analyze various factors that might be in correlation relationship with the development of fibrinous reaction in the anterior chamber after phacoemulsification surgery. Let`s also present our clinical experience in the treatment of acute fibrinous exudation.Material and methodsThe design of the present clinical study is retrospective and observational, with tracked period 04.01- 15.12.2017. Criteria for inclusion in the study were standard phacoemulsification of the lens without intraoperative complications and implantation of IOL into the capsuler bag. The exclusion criteria taken into account for the purpose of differentiating the risk factors only for the phacoemulsification as a surgical method are executing the one-step combined surgical procedure (phacoemulsification with trabeculectomy, phacoemulsification with pars plan vitrectomy). The preoperative set of studies performed includes a thorough ophthalmologic exam, indirect ophthalmoscopy, Goldmann tonometry, keratometry and biometric ultrasonic A echography. To all 191 participants in the study, of which 67 men (35.1%) and 124 women (64.9%), with average age Γ΄β¬βΒ§ 68 years, by planned order was assigned a phacoemulsification of the lens with implanted intraocular artificial lens (IOL). All operations were performed in the 3rd ward of the Ophthalmology Clinic, University Hospital `Aleksandrovska`, by one surgeon, according to the same methodology approved in the clinic.ResultsTo all 191 patients (191 eyes) was accomplished phacoemulsification of the lens and implanted an IOL, according to a methodology approved in the ward without any complications. 78 (40.8%) of the participants had a hydrophobic, acrylic, aspheric implant, while the other group of 113 (59.2%) participants had a hydrophilic, acrylic, aspheric IOL. The patients with conventional monofocal (hydrophilic and hydrophobic) IOL were 162 (84.8%) and 29 (15.2%) were with implanted hydrophilic IOL with extended depth of focus. Fibrinous exudation in the anterior chamber during the early postoperative period was found in five patients (2.4%) of the studied cohort. After local therapy with anti-inflammatory drugs (corticosteroids), the fibrinous membrane in each of the five patients is completely absorbed. It was reported that the presence of diabetes mellitus (80% of the patients with exudation) as an accompanying disease and the implantation of monofocal hydrophilic IOL (for 100% of patients with exudation) were the factors with the highest predictive value for developing a pathological fibrinous reaction.ConclusionSenile cataract is among the main age-related eye diseases. Its frequency increases as the age advances. In the national and world scale, phacoemulsification is the most commonly performed surgical intervention in ophthalmology. The variety of intraocular artificial lenses nowadays is enormous, aiming to satisfy the ever-increasing demands and standards in ocular surgery. The rising incidence of diabetes mellitus poses new and important questions about which type of IOL are the most appropriate and recommended in patients with systemic accompanying diseases
hArtes: Hardware-Software Codesign for Heterogeneous Multicore Platforms
Developing heterogeneous multicore platforms requires choosing the best hardware configuration for mapping the application, and modifying that application so that different parts execute on the most appropriate hardware component. The hArtes toolchain provides the option of automatic or semi-automatic support for this mapping. During test and validation on several computation-intensive applications, hArtes achieved substantial speedups and drastically reduced development times
The formation of oxidative disorders in the population of Vladivostok under the influence of atmospheric microparticles
We studied the response of trigger systems in healthy volunteers living in areas with different levels of air pollution. We determined that particles with the size of 800 microns and higher of relatively favorable region, particles with the size of less than 50 microns dominated in the air of the unfavorable area, among which there were the most hazardous to health amounts of microparticles - from 200 to 300 nm. Microparticles of unfavorable area causes the development of oxidative modifications of proteins and DNA contributing to the change of leukocyte potential energy. The increase in total antioxidant activity and response of thiol-disulfide system (the increase in thioredoxin, glutathione with a stable reductase level] maintains a balance of oxidation and antioxidant processes contributing to protection of the cellular and subcellular structures against considerable oxidative damage
Efficient Synthesis of Fluorescent Coumarins and Phosphorous-Containing Coumarin-Type Heterocycles via Palladium Catalyzed Cross-Coupling Reactions
Quantum-chemical calculations on the spectral properties of some aryl substituted 3-
phosphonocoumarins were performed, and the effect of the substituents in the aryl moiety was
evaluated. The structures possessing promising fluorescent properties were successfully synthesized via Suzuki and Sonogashira cross-coupling. The synthetic protocol was also applied for the
phosphorous chemoisomer of 3-phosphonocoumarin, 1,2-benzoxaphosphorin, and their carboxylate
analogues. The optical properties of the arylated and alkynylated products were experimentally
determined. The obtained quantum-chemical and experimental results give the possibility for a
fine tuning of the optical properties of phosphorous-containing coumarin systems by altering the
substituent at its C-6 position
A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies
In Alzheimerβs disease (AD) and related tauopathies, the microtubule-associated protein tau is highly phosphorylated and aggregates to form neurofibrillary tangles that are characteristic of these neurodegenerative diseases. Our previous work has demonstrated that the thousand-and-one amino acid kinases (TAOKs) 1 and 2 phosphorylate tau on more than 40 residues in vitro. Here we show that TAOKs are phosphorylated and active in AD brain sections displaying mild (Braak stage II), intermediate (Braak stage IV) and advanced (Braak stage VI) tau pathology and that active TAOKs co-localise with both pre-tangle and tangle structures. TAOK activity is also enriched in pathological tau containing sarkosyl-insoluble extracts prepared from AD brain. Two new phosphorylated tau residues (T123 and T427) were identified in AD brain, which appear to be targeted specifically by TAOKs. A new small molecule TAOK inhibitor (Compound 43) reduced tau phosphorylation on T123 and T427 and also on additional pathological sites (S262/S356 and S202/T205/S208) in vitro and in cell models. The TAOK inhibitor also decreased tau phosphorylation in differentiated primary cortical neurons without affecting markers of synapse and neuron health. Notably, TAOK activity also co-localised with tangles in post-mortem frontotemporal lobar degeneration (FTLD) brain tissue. Furthermore, the TAOK inhibitor decreased tau phosphorylation in induced pluripotent stem cell derived neurons from FTLD patients, as well as cortical neurons from a transgenic mouse model of tauopathy (Tau35 mice). Our results demonstrate that abnormal TAOK activity is present at pre-tangles and tangles in tauopathies and that TAOK inhibition effectively decreases tau phosphorylation on pathological sites. Thus, TAOKs may represent a novel target to reduce or prevent tau-associated neurodegeneration in tauopathies
Ancient human mitochondrial genomes from Bronze Age Bulgaria: new insights into the genetic history of Thracians
Abstract One of the best documented Indo-European civilizations that inhabited Bulgaria is the Thracians, who lasted for more than five millennia and whose origin and relationships with other past and present-day populations are debated among researchers. Here we report 25 new complete mitochondrial genomes of ancient individuals coming from three necropolises located in different regions of Bulgaria β Shekerdja mogila, Gabrova mogila and Bereketska mogila β dated to II-III millennium BC. The identified mtDNA haplogroup composition reflects the mitochondrial variability of Western Eurasia. In particular, within the ancient Eurasian genetic landscape, Thracians locate in an intermediate position between Early Neolithic farmers and Late Neolithic-Bronze Age steppe pastoralists, supporting the scenario that the Balkan region has been a link between Eastern Europe and the Mediterranean since the prehistoric time. Spatial Principal Component Analysis (sPCA) performed on Thracian and modern mtDNA sequences, confirms the pattern highlighted on ancient populations, overall indicating that the maternal gene pool of Thracians reflects their central geographical position at the gateway of Europe
The hArtes Tool Chain
This chapter describes the different design steps needed to go from legacy code to a transformed application that can be efficiently mapped on the hArtes platform
Three-dimensional reconstruction of synapses and dendritic spines in the rat and ground squirrel hippocampus: New structural-functional paradigms for synaptic function
Published data are reviewed along with our own data on synaptic plasticity and rearrangements of synaptic organelles in the central nervous system. Contemporary laser scanning and confocal microscopy techniques are discussed, along with the use of serial ultrathin sections for in vivo and in vitro studies of dendritic spines, including those addressing relationships between morphological changes and the efficiency of synaptic transmission, especially in conditions of the long-term potentiation model. Different categories of dendritic spines and postsynaptic densities are analyzed, as are the roles of filopodia in originating spines. The role of serial ultrathin sections for unbiased quantitative stereological analysis and three-dimensional reconstruction is assessed. The authors data on the formation of more than two synapses on single mushroom spines on neurons in hippocampal field CA1 are discussed. Analysis of these data provides evidence for new paradigms in both the organization and functioning of synapses
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