How strongly do plumes influence Pacific seamount distribution?

Seamounts are submarine volcanoes postulated to be formed either by hot mantle plumes rising from the deep mantle or by shallow, plate-related processes. However, the relative importance of these two mechanisms has not hitherto been quantified. In this study, applying Gaussian Process regression to reconstruct irregular seamount topography above and under the sedimentary layer, we calculate an accurate map of volcanism distribution within the Pacific plate. We find that previous erupted volumes have been underestimated by 75% on average. Our results show that (1) the total erupted volume postulated to be plume-related makes up only 18% of total Pacific intraplate volcanism, and (2) the volume statistics for plume-related seamounts and those along the Large Low-Shear-Velocity Province margins are nearly indistinguishable from the rest of the intraplate seamounts. We conclude that proposed plumes account for only a minority of the volume of intraplate volcanism in the Pacific plate, implying that shallow rather than deep processes are dominant

Influences of phase transition and microstructure on dielectric properties of Bi0.5Na0.5Zr1-xTixO3 ceramics

Bismuth sodium zirconate titanate ceramics with the formula Bi0.5Na0.5Zr1-xTixO3 [BNZT], where x = 0.3, 0.4, 0.5, and 0.6, were prepared by a conventional solid-state sintering method. Phase identification was investigated using an X-ray diffraction technique. All compositions exhibited complete solubility of Ti4+ at the Zr4+ site. Both a decrease of unit cell size and phase transition from an orthorhombic Zr-rich composition to a rhombohedral crystal structure in a Ti-rich composition were observed as a result of Ti4+ substitution. These changes caused dielectric properties of BNZT ceramics to enhance. Microstructural observation carried out employing SEM showed that average grain size decreased when addition of Ti increased. Grain size difference of BNZT above 0.4 mole fraction of Ti4+ displayed a significant increase of dielectric constant at room temperature

Big data, big challenges: risk management of financial market in the digital economy

Purpose– The purpose of the research is to assess the risk of the financial market in the digital economy through the quantitative analysis model in the big data era. It’s a big challenge for the government to carry out financial market risk management in the big data era. Design/methodology/approach– In this study, a generalized autoregressive conditional heteroskedasticity-vector autoregression (GARCH-VaR) model is constructed to analyze the big data financial market in the digital economy. Additionally, the correlation test and stationarity test are carried out to construct the best fit model and get the corresponding VaR value. Findings– Owing to the conditional heteroscedasticity, the index return series shows the leptokurtic and fat tail phenomenon. According to the AIC (Akaike Information Criterion), the fitting degree of the GARCH model is measured. The AIC value difference of the models under the three distributions is not obvious, and the differences between them can be ignored. Originality/value– Using the GARCH-VaR model can better measure and predict the risk of the big data finance market and provide a reliable and quantitative basis for the current technology-driven regulation in the digital economy

Mantle Flow Underneath the South China Sea Revealed by Seismic Anisotropy

It Has Long Been Established that Plastic Flow in the Asthenosphere Interacts Constantly with the overlying Lithosphere and Plays a Pivotal Role in Controlling the Occurrence of Geohazards Such as Earthquakes and Volcanic Eruptions. Unfortunately, Accurately Characterizing the Direction and Lateral Extents of the Mantle Flow Field is Notoriously Difficult, Especially in Oceanic Areas Where Deployment of Ocean Bottom Seismometers (OBSs) is Expensive and Thus Rare. in This Study, by Applying Shear Wave Splitting Analyses to a Dataset Recorded by an OBS Array that We Deployed between Mid-2019 and Mid-2020 in the South China Sea (SCS), We Show that the Dominant Mantle Flow Field Has a NNW-SSE Orientation, Which Can Be Attributed to Mantle Flow Extruded from the Tibetan Plateau by the Ongoing Indian-Eurasian Collision. in Addition, the Results Suggest that E-W Oriented Flow Fields Observed in South China and the Indochina Peninsula Do Not Extend to the Central SCS

Combination of 4-1BB and DAP10 promotes proliferation and persistence of NKG2D(bbz) CAR-T cells

Chimeric antigen receptor (CAR)-T cell therapy has been shown to have considerable therapeutic effects in hematological malignancies, and NKG2D(z) CAR-T cell therapy has been verified to be safe based on clinical trials. However, due to the poor persistence of NKG2D(z) CAR-T cells, their therapeutic effect is not obvious. Here, we constructed NKG2D(bbz) CAR-T cells that can simultaneously activate 4-1BB and DAP10 costimulatory signaling. They were found to be cytotoxic to the target cells in vitro and in vivo. They exhibited low differentiation, low exhaustion, and good proliferation. Importantly, the proportions of central memory T (Tcm) and stem cell-like memory T (Tscm) cell subsets were strikingly increased. After long-term incubation with the target cells, they displayed reduced exhaustion compared to NKG2D(z) CAR-T cells. Further, in the presence of the phosphoinositide 3-kinase (PI3K) inhibitor LY294002, they exhibited reduced exhaustion and apoptosis, upregulated Bcl2 expression, and an increased proportion of Tcm cell subsets. Finally, NKG2D(bbz) CAR-T cells had better antitumor effects in vivo. In summary, the results showed that NKG2D(bbz) CAR-T cells may be valuable for cellular immunotherapy of cancer

Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell Carcinoma

Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide and the fourth most lethal cancer in China. However, although genomic studies have identified some mutations associated with ESCC, we know little of the mutational processes responsible. To identify genome-wide mutational signatures, we performed either whole-genome sequencing (WGS) or whole-exome sequencing (WES) on 104 ESCC individuals and combined our data with those of 88 previously reported samples. An APOBEC-mediated mutational signature in 47% of 192 tumors suggests that APOBEC-catalyzed deamination provides a source of DNA damage in ESCC. Moreover, PIK3CA hotspot mutations (c.1624G>A [p.Glu542Lys] and c.1633G>A [p.Glu545Lys]) were enriched in APOBEC-signature tumors, and no smoking-associated signature was observed in ESCC. In the samples analyzed by WGS, we identified focal (<100 kb) amplifications of CBX4 and CBX8. In our combined cohort, we identified frequent inactivating mutations in AJUBA, ZNF750, and PTCH1 and the chromatin-remodeling genes CREBBP and BAP1, in addition to known mutations. Functional analyses suggest roles for several genes (CBX4, CBX8, AJUBA, and ZNF750) in ESCC. Notably, high activity of hedgehog signaling and the PI3K pathway in approximately 60% of 104 ESCC tumors indicates that therapies targeting these pathways might be particularly promising strategies for ESCC. Collectively, our data provide comprehensive insights into the mutational signatures of ESCC and identify markers for early diagnosis and potential therapeutic targets

A Light-Thin Chitosan Nanofiber Separator for High-Performance Lithium-Ion Batteries

With the development of portable devices and wearable devices, there is a higher demand for high-energy density and light lithium-ion batteries (LIBs). The separator is a significant component directly affecting the performance of LIBs. In this paper, a thin and porous chitosan nanofiber separator was successfully fabricated using the simple ethanol displacement method. The thickness of the CME15 separator was about half that of mainstream commercial Celgard2325 separators. Owing to its inherent polarity and high porosity, the obtained CME15 separator achieved a small contact angle (18°) and excellent electrolyte wettability (324% uptake). The CME15 separator could maintain excellent thermal dimensional stability at 160 °C. Furthermore, the CME15 separator-based LIBs exhibited excellent cycling performance after 100 cycles (117 mAh g−1 at 1 C). The present work offers a perspective on applying a chitosan nanofiber separator in light and high-performance lithium-ion batteries (LIBs)

Creep Behaviors of Methane Hydrate-Bearing Frozen Sediments

Creep behaviors of methane hydrate-bearing frozen specimens are important to predict the long-term stability of the hydrate-bearing layers in Arctic and permafrost regions. In this study, a series of creep tests were conducted, and the results indicated that: (1) higher deviator stress (external load) results in larger initial strain, axial strain, and strain rate at a specific elapsed time. Under low deviator stress levels, the axial strain is not large and does not get into the tertiary creep stage in comparison with that under high deviator stress, which can be even up to 35% and can cause failure; (2) both axial strain and strain rate of methane hydrate-bearing frozen specimens increase with the enhancement of deviator stress, the decrease of confining pressure, and the decrease of temperature; (3) the specimens will be damaged rather than in stable creep stage during creeping when the deviator stress exceeds the quasi-static strength of the specimens

Proper Biochar Increases Maize Fine Roots and Yield via Altering Rhizosphere Bacterial Communities under Plastic Film Mulching

Biochar amendment is considered a sustainable agricultural strategy to improve crop yields. However, information on grain yield, fine roots and in relation to rhizosphere microbial communities in maize under plastic film mulching is very limited. Herein, biochar applied every 2 years (8.4 t ha−1, B1) and biochar applied every 5 years (21 t ha−1, B2) combined with nitrogen (225 kg ha−1), or nitrogen alone, were tested in a field experiment. The results showed that a biochar–fertilizer application significantly decreased the root length at the V9 stage, but biochar applied every 5 years significantly maintained the root length at the R6 stage. Biochar–fertilizer application increased grain yield under the B1 treatment while slightly decreasing under the B2 treatment. The rhizosphere of maize was preferentially colonized by Proteobacteria, Firmicutes, Sphingomonas, and Bradyrhizobium. Dominant phyla including Proteobacteria were enriched in bulk soils, while Bacteroidetes and Firmicutes were depleted in rhizosphere and bulk soils under the biochar–fertilizer application. Changes in root morphology and soil properties were responsible for bacterial community structure in response to different biochar applications. Thus, we concluded that the differential responses of maize yield and root attributes might be related to the specific biochar dose-specific effects on soil microbiome diversity