Problem dependent metaheuristic performance in Bayesian network structure learning.

Bayesian network (BN) structure learning from data has been an active research area in the machine learning field in recent decades. Much of the research has considered BN structure learning as an optimization problem. However, the finding of optimal BN from data is NP-hard. This fact has driven the use of heuristic algorithms for solving this kind of problem. Amajor recent focus in BN structure learning is on search and score algorithms. In these algorithms, a scoring function is introduced and a heuristic search algorithm is used to evaluate each network with respect to the training data. The optimal network is produced according to the best score evaluated. This thesis investigates a range of search and score algorithms to understand the relationship between technique performance and structure features of the problems. The main contributions of this thesis include (a) Two novel Ant Colony Optimization based search and score algorithms for BN structure learning; (b) Node juxtaposition distribution for studying the relationship between the best node ordering and the optimal BN structure; (c) Fitness landscape analysis for investigating the di erent performances of both chain score function and the CH score function; (d) A classifier method is constructed by utilizing receiver operating characteristic curve with the results on fitness landscape analysis; and finally (e) a selective o -line hyperheuristic algorithm is built for unseen BN structure learning with search and score algorithms. In this thesis, we also construct a new algorithm for producing BN benchmark structures and apply our novel approaches to a range of benchmark problems and real world problem

Recent advances in research on aspartate β-hydroxylase (ASPH) in pancreatic cancer: A brief update

Pancreatic cancer (PC) is a highly aggressive tumor, often difficult to diagnose and treat. Aspartate β-hydroxylase (ASPH) is a type II transmembrane protein and the member of α-ketoglutarate-dependent dioxygenase family, found to be overexpressed in different cancer types, including PC. ASPH appears to be involved in the regulation of proliferation, invasion and metastasis of PC cells through multiple signaling pathways, suggesting its role as a tumor biomarker and therapeutic target. In this review, we briefly summarize the possible mechanisms of action of ASPH in PC and recent progress in the therapeutic approaches targeting ASPH

Gender-specific association between the regular use of statins and the risk of irritable bowel syndrome: A population-based prospective cohort study

Introduction: In addition to lipid-lowering effects, statins might modulate the gut microbiome and alleviate systematic inflammation, which in turn, may have a protective effect against irritable bowel syndrome (IBS). The aim of our study was to evaluate the gender-specific association between statin exposure and the risk of IBS.Method: We undertook a prospective analysis based on the United Kingdom Biobank, a large ongoing cohort including 477,293 participants aged 37–73 years. We included participants based on information on their personal statin use and also those free of IBS and cancer at the baseline. We evaluated the gender-specific hazard ratio (HR) and 95% confidence interval (CI) with Cox proportional hazards regression, adjusting for demographic factors, lifestyle factors, comorbidities, and statin indications.Result: A total of 438,805 participants (206,499 males and 232,306 females) were included in the analysis. Among male participants, the regular use of statins was associated with a decreased risk of IBS (HR: 0.77; 95% CI: 0.61–0.97). This association persists across multiple sensitivity and subgroup analyses and did not show clear evidence of variance among the major types of statins. We did not find sufficient evidence of the association between the statin use and IBS risk in females (HR: 0.98; 95% CI: 0.82–1.16).Conclusion: Our study found that the regular use of statins was associated with a decreased risk of IBS in male participants. Further studies are required to confirm the beneficial effect of statins

Industrial technology progress, digital finance development and corporate risk-taking: Evidence from China's listed firms.

Industrial technological progress, as an essential industrial-technological and institutional phenomenon, brings with it the possibility of high profits for firms but also implies new norms and rules of competition, which affect the willingness and propensity of firms to bear the costs of undertaking venture capital projects. This study empirically investigates the causal impact of industrial-technological progress on corporate risk-taking and the mechanism of digital financial growth on the relationship between the two, based on data from China's A-share listed businesses from 2011 to 2020. This paper finds that (1) industrial technological progress improves enterprise risk-taking levels. Moreover, digital financial development has an incentive effect on industrial technological progress and enterprise risk-taking levels. (2) Industrial technological progress under digital financial development generates financing constraint relaxation effects, input capital return enhancement effects, and innovation performance incentive effects, increasing enterprise risk-taking. (3) The positive moderating effect of digital financial development on the relationship between industrial technological progress and the risk-taking level of enterprises in the eastern regions and enterprises in the high-tech industry is more prominent. The study's findings provide a theoretical foundation and policy insights on the crucial elements of industrial-technological progress and enterprises' increased ability to take risks throughout the development of digital finance

Application of Hierarchical Facility Location-Routing Problem with Optimization of an Underground Logistic System: A Case Study in China

Facility location problem (FLP) and vehicle routing problem (VRP) are two of the most challenging issues in logistics. This paper presents an exploration of the multinode facility location-routing problem with realistic conditions. The disposal centers, transfer stations, connected collection sites, and unconnected collection sites are built into a new hierarchical model which is solved by Generate Algorithm (GA). Model costs include node construction cost, pipeline construction cost, transport cost, and transfer cost. This paper considers that the transportation is a bidirectional flow not a single flow; each pairs node in the area needs transportation; the dynamic routing selection method is used to determine the routes of unconnected collection sites. FLP and VRP can be both solved in this model. To illustrate the applicability of the model, a case study is presented and the results are discussed. The model in this paper can reduce the cost of the traditional underground logistics system by 6%~8% in experiments

Heterogeneity analysis.

Industrial technological progress, as an essential industrial-technological and institutional phenomenon, brings with it the possibility of high profits for firms but also implies new norms and rules of competition, which affect the willingness and propensity of firms to bear the costs of undertaking venture capital projects. This study empirically investigates the causal impact of industrial-technological progress on corporate risk-taking and the mechanism of digital financial growth on the relationship between the two, based on data from China’s A-share listed businesses from 2011 to 2020. This paper finds that (1) industrial technological progress improves enterprise risk-taking levels. Moreover, digital financial development has an incentive effect on industrial technological progress and enterprise risk-taking levels. (2) Industrial technological progress under digital financial development generates financing constraint relaxation effects, input capital return enhancement effects, and innovation performance incentive effects, increasing enterprise risk-taking. (3) The positive moderating effect of digital financial development on the relationship between industrial technological progress and the risk-taking level of enterprises in the eastern regions and enterprises in the high-tech industry is more prominent. The study’s findings provide a theoretical foundation and policy insights on the crucial elements of industrial-technological progress and enterprises’ increased ability to take risks throughout the development of digital finance.</div

Descriptive statistics.

Industrial technological progress, as an essential industrial-technological and institutional phenomenon, brings with it the possibility of high profits for firms but also implies new norms and rules of competition, which affect the willingness and propensity of firms to bear the costs of undertaking venture capital projects. This study empirically investigates the causal impact of industrial-technological progress on corporate risk-taking and the mechanism of digital financial growth on the relationship between the two, based on data from China’s A-share listed businesses from 2011 to 2020. This paper finds that (1) industrial technological progress improves enterprise risk-taking levels. Moreover, digital financial development has an incentive effect on industrial technological progress and enterprise risk-taking levels. (2) Industrial technological progress under digital financial development generates financing constraint relaxation effects, input capital return enhancement effects, and innovation performance incentive effects, increasing enterprise risk-taking. (3) The positive moderating effect of digital financial development on the relationship between industrial technological progress and the risk-taking level of enterprises in the eastern regions and enterprises in the high-tech industry is more prominent. The study’s findings provide a theoretical foundation and policy insights on the crucial elements of industrial-technological progress and enterprises’ increased ability to take risks throughout the development of digital finance.</div

Definition of variables.

Industrial technological progress, as an essential industrial-technological and institutional phenomenon, brings with it the possibility of high profits for firms but also implies new norms and rules of competition, which affect the willingness and propensity of firms to bear the costs of undertaking venture capital projects. This study empirically investigates the causal impact of industrial-technological progress on corporate risk-taking and the mechanism of digital financial growth on the relationship between the two, based on data from China’s A-share listed businesses from 2011 to 2020. This paper finds that (1) industrial technological progress improves enterprise risk-taking levels. Moreover, digital financial development has an incentive effect on industrial technological progress and enterprise risk-taking levels. (2) Industrial technological progress under digital financial development generates financing constraint relaxation effects, input capital return enhancement effects, and innovation performance incentive effects, increasing enterprise risk-taking. (3) The positive moderating effect of digital financial development on the relationship between industrial technological progress and the risk-taking level of enterprises in the eastern regions and enterprises in the high-tech industry is more prominent. The study’s findings provide a theoretical foundation and policy insights on the crucial elements of industrial-technological progress and enterprises’ increased ability to take risks throughout the development of digital finance.</div