Evacuation characteristics of preschool children through bottlenecks

Pedestrian movement through bottlenecks have been widely studied from various aspects to understand the effects of bottlenecks on the pedestrian flow. However, few attentions have been paid to the movement characteristics of preschool children, who show obvious differences behaviour compared to adults due to the poor balance and understanding of danger especial under emergencies. In this study, we focus on the evacuation characteristics of preschool children through bottlenecks with laboratory experiments. From all the experiment, we do not observe clear lane formation process from the trajectories diagrams. It is found that the first arrive first out principle does not work in the situation with competition. Compared to adults, children are more likely to fall and hard to be controlled during movement, which is very dangerous in emergencies. The highest speed for the preschool children can beyond 3 m/s and is depend on the location in the crowd for each individual. For a given number of evacuees, the total evacuation time firstly decreases a linear with the increasing the bottleneck width and then keeps a constant if nobody falls down during the movement. Falling down of children will increase the evacuation time incredibly. The findings will be beneficial for the evacuation drill design in kindergarten as well as the facility design for young children

Stretchable hybrid bilayered luminescent composite based on the combination of strain-induced and triboelectrification-induced electroluminescence

High luminescence intensity from materials that are excited by external stimuli is highly desired. In this work, a stretchable hybrid luminescent composite (HLC) that has multiple luminescence modes is reported. The luminescence can be excited either by externally applied mechanical strain or by a moving object that slides against the HLC. When the HLC is deformed, such as being twisted or folded, the ZnS/Cu phosphor experiences mechanical strain that trigger the mechanoluminescence (ML) of the phosphors. Moreover, as the HLC slides against a contact object, the triboelectrification at the contact interface induces the electroluminescence of phosphor. Here, a series of internal and external factors were studied on how they influence the luminescent intensity. It is found that the luminescent intensity from the two modes can be superposed. The HLC material was used to fabricate a fiber-based luminescent device that can be driven by air flow. The overall luminescent intensity is enhanced by over 72% compared to that obtained solely from the ML. The HLC reported in this work has such potential applications as self-powered light sources and sensors as means of detecting dynamic motions and interactio

Influences of phase transition and microstructure on dielectric properties of Bi0.5Na0.5Zr1-xTixO3 ceramics

Bismuth sodium zirconate titanate ceramics with the formula Bi0.5Na0.5Zr1-xTixO3 [BNZT], where x = 0.3, 0.4, 0.5, and 0.6, were prepared by a conventional solid-state sintering method. Phase identification was investigated using an X-ray diffraction technique. All compositions exhibited complete solubility of Ti4+ at the Zr4+ site. Both a decrease of unit cell size and phase transition from an orthorhombic Zr-rich composition to a rhombohedral crystal structure in a Ti-rich composition were observed as a result of Ti4+ substitution. These changes caused dielectric properties of BNZT ceramics to enhance. Microstructural observation carried out employing SEM showed that average grain size decreased when addition of Ti increased. Grain size difference of BNZT above 0.4 mole fraction of Ti4+ displayed a significant increase of dielectric constant at room temperature

Stretchable elastic synaptic transistors for neurologically integrated soft engineering systems

Artificial synaptic devices that can be stretched similar to those appearing in soft-bodied animals, such as earthworms, could be seamlessly integrated onto soft machines toward enabled neurological functions. Here, we report a stretchable synaptic transistor fully based on elastomeric electronic materials, which exhibits a full set of synaptic characteristics. These characteristics retained even the rubbery synapse that is stretched by 50%. By implementing stretchable synaptic transistor with mechanoreceptor in an array format, we developed a deformable sensory skin, where the mechanoreceptors interface the external stimulations and generate presynaptic pulses and then the synaptic transistors render postsynaptic potentials. Furthermore, we demonstrated a soft adaptive neurorobot that is able to perform adaptive locomotion based on robotic memory in a programmable manner upon physically tapping the skin. Our rubbery synaptic transistor and neurologically integrated devices pave the way toward enabled neurological functions in soft machines and other applications

Global systematic review with meta-analysis shows that warming effects on terrestrial plant biomass allocation are influenced by precipitation and mycorrhizal association

Biomass allocation in plants is fundamental for understanding and predicting terrestrial carbon storage. Yet, our knowledge regarding warming effects on root: shoot ratio (R/S) remains limited. Here, we present a meta-analysis encompassing more than 300 studies and including angiosperms and gymnosperms as well as different biomes (cropland, desert, forest, grassland, tundra, and wetland). The meta-analysis shows that average warming of 2.50 °C (median = 2 °C) significantly increases biomass allocation to roots with a mean increase of 8.1% in R/S. Two factors associate significantly with this response to warming: mean annual precipitation and the type of mycorrhizal fungi associated with plants. Warming-induced allocation to roots is greater in drier habitats when compared to shoots (+15.1% in R/S), while lower in wetter habitats (+4.9% in R/S). This R/S pattern is more frequent in plants associated with arbuscular mycorrhizal fungi, compared to ectomycorrhizal fungi. These results show that precipitation variability and mycorrhizal association can affect terrestrial carbon dynamics by influencing biomass allocation strategies in a warmer world, suggesting that climate change could influence belowground C sequestration

Mycorrhizal associations relate to stable convergence in plant-microbial competition for nitrogen absorption under high nitrogen conditions

117 págibnas.- 4 figuras.- referencias.-Nitrogen (N) immobilization (Nim, including microbial N assimilation) and plant N uptake (PNU) are the two most important pathways of N retention in soils. The ratio of Nim to PNU (hereafter Nim:PNU ratio) generally reflects the degree of N limitation for plant growth in terrestrial ecosystems. However, the key factors driving the pattern of Nim:PNU ratio across global ecosystems remain unclear. Here, using a global data set of 1018 observations from 184 studies, we examined the relative importance of mycorrhizal associations, climate, plant, and soil properties on the Nim:PNU ratio across terrestrial ecosystems. Our results show that mycorrhizal fungi type (arbuscular mycorrhizal (AM) or ectomycorrhizal (EM) fungi) in combination with soil inorganic N mainly explain the global variation in the Nim:PNU ratio in terrestrial ecosystems. In AM fungi-associated ecosystems, the relationship between Nim and PNU displays a weaker negative correlation (r = −.06, p < .001), whereas there is a stronger positive correlation (r = .25, p < .001) in EM fungi-associated ecosystems. Our meta-analysis thus suggests that the AM-associated plants display a weak interaction with soil microorganisms for N absorption, while EM-associated plants cooperate with soil microorganisms. Furthermore, we find that the Nim:PNU ratio for both AM- and EM-associated ecosystems gradually converge around a stable value (13.8 ± 0.5 for AM- and 12.1 ± 1.2 for EM-associated ecosystems) under high soil inorganic N conditions. Our findings highlight the dependence of plant–microbial interaction for N absorption on both plant mycorrhizal association and soil inorganic N, with the stable convergence of the Nim:PNU ratio under high soil N conditions.This research was financially supported by the National Natural Science Foundation of China (grant nos. 32241032, 31930072, 42261144688, 32271713, 32071593, and 42203076), and the Fundamental Research Funds for the Central Universities (grant no. 2572022BA08). MPT acknowledges the support from the Swiss State Secretariat for Education, Research and Innovation (SERI) under contract number: M822.00029. G. Zhou acknowledges the support from Ramón y Cajal project (RYC2022-035226-I) funded by the Spanish Ministry of Science and Innovation, the NextGenerationEU program of the European Union (MICIU/AEI/10.13039/501100011033 y el FSE+), and AYUDAS DE EXCELENCIA RYC-MAX 2023 project from Spanish National Research Council.Peer reviewe

Combination of 4-1BB and DAP10 promotes proliferation and persistence of NKG2D(bbz) CAR-T cells

Chimeric antigen receptor (CAR)-T cell therapy has been shown to have considerable therapeutic effects in hematological malignancies, and NKG2D(z) CAR-T cell therapy has been verified to be safe based on clinical trials. However, due to the poor persistence of NKG2D(z) CAR-T cells, their therapeutic effect is not obvious. Here, we constructed NKG2D(bbz) CAR-T cells that can simultaneously activate 4-1BB and DAP10 costimulatory signaling. They were found to be cytotoxic to the target cells in vitro and in vivo. They exhibited low differentiation, low exhaustion, and good proliferation. Importantly, the proportions of central memory T (Tcm) and stem cell-like memory T (Tscm) cell subsets were strikingly increased. After long-term incubation with the target cells, they displayed reduced exhaustion compared to NKG2D(z) CAR-T cells. Further, in the presence of the phosphoinositide 3-kinase (PI3K) inhibitor LY294002, they exhibited reduced exhaustion and apoptosis, upregulated Bcl2 expression, and an increased proportion of Tcm cell subsets. Finally, NKG2D(bbz) CAR-T cells had better antitumor effects in vivo. In summary, the results showed that NKG2D(bbz) CAR-T cells may be valuable for cellular immunotherapy of cancer