462 research outputs found
OL-049 Epidemiology and molecular characteristics of community-associated methicillin-resistant and methicillin-susceptible Staphylococcus aureus from skin/soft tissue infections in Beijing Children's Hospital, China
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex
Mutations in PKD1 and TRPP2 account for nearly all cases of autosomal dominant polycystic kidney disease (ADPKD). These 2 proteins form a receptor/ion channel complex on the cell surface. Using a combination of biochemistry, crystallography, and a single-molecule method to determine the subunit composition of proteins in the plasma membrane of live cells, we find that this complex contains 3 TRPP2 and 1 PKD1. A newly identified coiled-coil domain in the C terminus of TRPP2 is critical for the formation of this complex. This coiled-coil domain forms a homotrimer, in both solution and crystal structure, and binds to a single coiled-coil domain in the C terminus of PKD1. Mutations that disrupt the TRPP2 coiled-coil domain trimer abolish the assembly of both the full-length TRPP2 trimer and the TRPP2/PKD1 complex and diminish the surface expression of both proteins. These results have significant implications for the assembly, regulation, and function of the TRPP2/PKD1 complex and the pathogenic mechanism of some ADPKD-producing mutations
Effect of the flow leading slats obliquity on the thermal performance of air-cooled condensers in a power plant
Paper presented at the 8th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Mauritius, 11-13 July, 2011.Ambient winds may bring on poor fan performance and
deteriorated heat rejection of the air-cooled condensers in a
power plant. The disadvantageous wind impacts can be
weakened thanks to the flow field leading of the wind. By
introducing a radiator model to the fin-tube bundles, the airside
fluid and heat flow in air-cooled condensers with a flow
guiding device in a representative 2 × 600MW direct dry
cooling power plant are modeled and calculated. The flow rate
and heat rejection of the individual condenser cells and the aircooled
condensers with flow guiding devices at different slat
obliquities are obtained and compared. The results show that
the flow rate and heat rejection of the air-cooled condensers
both increase owing to the setup of the flow guiding device.
The low flow guiding slats obliquity is superior to the high one
for the thermo-flow performances. For the upwind condenser
cells, the flow and heat transfer rates vary widely due to the
flow field leading of the ambient winds by the flow guiding
device especially at the lowered obliquity. It can be of use for
the optimal design and operation of air-cooled condensers in a
power plant.mp201
Epidemiology and Pathogenicity of Methicillin-Resistant Staphylococcus aureus Isolates from Pediatric Patients in China
Non-Markovian dynamics in a spin star system: The failure of thermalization
In most cases, a small system weakly interacting with a thermal bath will
finally reach the thermal state with the temperature of the bath. We show that
this intuitive picture is not always true by a spin star model where non-Markov
effect predominates in the whole dynamical process. The spin star system
consists a central spin homogeneously interacting with an ensemble of identical
noninteracting spins. We find that the correlation time of the bath is
infinite, which implies that the bath has a perfect memory, and that the
dynamical evolution of the central spin must be non- Markovian. A direct
consequence is that the final state of the central spin is not the thermal
state equilibrium with the bath, but a steady state which depends on its
initial state.Comment: 8 page
Direct Measurements of the Branching Fractions for and and Determinations of the Form Factors and
The absolute branching fractions for the decays and
are determined using singly
tagged sample from the data collected around 3.773 GeV with the
BES-II detector at the BEPC. In the system recoiling against the singly tagged
meson, events for and events for decays are observed. Those yield
the absolute branching fractions to be and . The
vector form factors are determined to be
and . The ratio of the two form
factors is measured to be .Comment: 6 pages, 5 figure
Search for the Lepton Flavor Violation Processes and
The lepton flavor violation processes and are
searched for using a sample of 5.8 events collected with
the BESII detector. Zero and one candidate events, consistent with the
estimated background, are observed in and
decays, respectively. Upper limits on the branching ratios are determined to be
and at the 90% confidence level (C.L.).Comment: 9 pages, 2 figure
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