Scalable and Low Power LDPC Decoder Design Using High Level Algorithmic Synthesis

This paper presents a scalable and low power low-density parity-check (LDPC) decoder design for the next generation wireless handset SoC. The methodology is based on high level synthesis: PICO (program-in chip-out) tool was used to produce efficient RTL directly from a sequential untimed C algorithm. We propose two parallel LDPC decoder architectures: (1) per-layer decoding architecture with scalable parallelism, and (2) multi-layer pipelined decoding architecture to achieve higher throughput. Based on the PICO technology, we have implemented a two-layer pipelined decoder on a TSMC 65nm 0.9V 8-metal layer CMOS technology with a core area of 1.2 mm2. The maximum achievable throughput is 415 Mbps when operating at 400 MHz clock frequency and the estimated peak power consumption is 180 mW.NokiaNokia Siemens Networks (NSN)XilinxNational Science Foundatio

Rethinking the Lives, Experiences and Behaviors of Hmong Women in Regard to their Ability to Achieve Empowerment and Agency and Finding Happiness.

This article consists of a book review of Claiming Place: On the Agency of Hmong Women, a scholarly work focused on both the historical and contemporary experiences of Hmong women as well as Hmong LGBTQ

Langue et scolarisation dans une communauté asiatique en France : les Hmong

Une communauté Hmong, originaire du Laos, est installée en France depuis une quinzaine d’années. L’enquête porte sur un échantillon de cette communauté habitant dans la ZUP de Nîmes. Elle étudie les particularités de la scolarisation des enfants Hmong, notamment le modèle éducatif, les modalités de l’accès à l’écrit et les représentations du savoir.A Hmong ethnic group originating from Laos, is established in France for some fifteen years now. This investigation bears upon a population sampling of members of that group living in the community social housing project (ZUP) of Mmes. This investigation bears upon what is spec ally different in the instructing of Hmong children, notably their society’s educational model, its ways and means of acceding to the written word and its representation of knowledge

Melatonin reduced volume of cerebral infarct induced by photothrombosis in wild-type mice, not in Cyclooxygenase-1 gene knockout mice

Cyclooxygenase (COX) is crucial in inflammation and plays important role in cerebral ischemia. Anti-inflammatory effects of melatonin have been verified in previous studies. In this study, cerebral blood flow (CBF) was monitored during operation, infarct volume (IFV) was determined with 5-triphenyltetrazolium chloride (TTC) staining and MR image, and neurological functions were evaluated with turn in an alley and fall pole test in both COX-1-gene knockout and wide-type mice with or without melatonin administration 3 days after photothrombosis. CBF reduction, IFV and neurological deficits were not significantly different in COX-1 wild-type and COX-1 knockout mice. Melatonin (15 mg/kg) intraperitoneal injection decreased the CBF reduction, IFV and the latency to turn in an alley in COX-1 wide-type mice, whereas the neuroprotective effect of melatonin was attenuated in COX-1 knockout mice. We concluded that melatonin reduced susceptibility to photothrombotic stroke. COX-1 gene knockout does not alter the susceptibility to cerebral ischemia caused by photothrombosis. COX-1 plays an important role in the pathway of the protection of melatonin.published_or_final_versio

Genetic diversity among natural populations of Ottelia acuminata (Gaghep.) Dandy revealed by ISSR

Ottelia acuminata (Gagnep.) Dandy, an aquatic species of the Hydrocharitaceae, is endemic to China. A performance comparison of genetic diversity of 4 natural populations was conducted to investigatewhether or not water pollution in their habitats has anything to do with this species being endangered. A total number of 120 O. acuminate accessions were analyzed, by amplification of their DNAs with 15 primers (ISSR). Thirteen primers were scored and 214 bands were detected, of which 170 werepolymorphic (79.44%). The results showed that the genetic indices in polluted Jian Lake group were always the smallest ones, when compared with those of the other groups. It indicated that the polluted water did affect the genetic diversity of O. acuminate populations. And ISSRs seemed to be effectivetools for detecting genetic variation among O. acuminate geographical groups

Efficient Image Retrieval via Decoupling Diffusion into Online and Offline Processing

Diffusion is commonly used as a ranking or re-ranking method in retrieval tasks to achieve higher retrieval performance, and has attracted lots of attention in recent years. A downside to diffusion is that it performs slowly in comparison to the naive k-NN search, which causes a non-trivial online computational cost on large datasets. To overcome this weakness, we propose a novel diffusion technique in this paper. In our work, instead of applying diffusion to the query, we pre-compute the diffusion results of each element in the database, making the online search a simple linear combination on top of the k-NN search process. Our proposed method becomes 10~ times faster in terms of online search speed. Moreover, we propose to use late truncation instead of early truncation in previous works to achieve better retrieval performance.Comment: Accepted by AAAI 201

Molecular analysis of the microbial community structures in water-flooding petroleum reservoirs with different temperatures

published_or_final_versio

An Empirical Methodology for Detecting and Prioritizing Needs during Crisis Events

In times of crisis, identifying the essential needs is a crucial step to providing appropriate resources and services to affected entities. Social media platforms such as Twitter contain vast amount of information about the general public's needs. However, the sparsity of the information as well as the amount of noisy content present a challenge to practitioners to effectively identify shared information on these platforms. In this study, we propose two novel methods for two distinct but related needs detection tasks: the identification of 1) a list of resources needed ranked by priority, and 2) sentences that specify who-needs-what resources. We evaluated our methods on a set of tweets about the COVID-19 crisis. For task 1 (detecting top needs), we compared our results against two given lists of resources and achieved 64% precision. For task 2 (detecting who-needs-what), we compared our results on a set of 1,000 annotated tweets and achieved a 68% F1-score

LAPTM4B Targeting as Potential Therapy for Hepatocellular Carcinoma

HCC is one of the most common cancers worldwide with high prevalence, recurrence, and lethality. The curative rate is not satisfactory. LAPTM4B is a novel driver gene of HCC first indentified by our group. It is over-expressed in 87.3% of HCC. The expression levels of the encoded LAPTM4B-35 protein in HCC is also over-expressed in 86.2% of HCC and shows a significant positive correlation with pathological grade, metastasis, and recurrence, and a negative correlation with postoperative overall- and cancer free- survival of HCC patients. Moreover, HCC cells showing high expression of LAPTM4B-35 show a strong tendency to metastasize and enhanced drug resistance. Overexpression of this gene promotes tumorigenesis, faster growth of human HCC xenografts and metastasis in nude mice, and leads to anti-apoptosis, deregulation of proliferation, enhancement of migration and invasion, as well as multi-drug resistance. In addition, overexpression of LAPTM4B-35 leads to accumulation of a number of oncoproteins and to down-regulation of a number of tumor suppressing proteins. By contrary, knockdown of endogenous LAPTM4B-35 via RNAi results in remarkable inhibition of xenograft growth and metastasis of human HCC in nude mice. Also, RNAi knockdown of LAPTN4B-35 can reverse the cellular and molecular malignant phenotypes noted above

Inhibitors of One or More Cellular Aurora Kinases Impair the Replication of Herpes Simplex Virus 1 and Other DNA and RNA Viruses with Diverse Genomes and Life Cycles

We utilized a high-throughput cell-based assay to screen several chemical libraries for inhibitors of herpes simplex virus 1 (HSV-1) gene expression. From this screen, four aurora kinase inhibitors were identified that potently reduced gene expression during HSV-1 lytic infection. HSV-1 is known to interact with cellular kinases to regulate gene expression by modulating the phosphorylation and/or activities of viral and cellular proteins. To date, the role of aurora kinases in HSV-1 lytic infection has not been reported. We demonstrated that three aurora kinase inhibitors strongly reduced the transcript levels of immediate-early (IE) genes ICP0, ICP4, and ICP27 and impaired HSV-1 protein expression from all classes of HSV-1, including ICP0, ICP4, ICP8, and gC. These restrictions caused by the aurora kinase inhibitors led to potent reductions in HSV-1 viral replication. The compounds TAK 901, JNJ 7706621, and PF 03814735 decreased HSV-1 titers by 4,500-, 13,200-, and 8,400-fold, respectively, when present in a low micromolar range. The antiviral activity of these compounds correlated with an apparent decrease in histone H3 phosphorylation at serine 10 (H3S10ph) during viral infection, suggesting that the phosphorylation status of H3 influences HSV-1 gene expression. Furthermore, we demonstrated that the aurora kinase inhibitors also impaired the replication of other RNA and DNA viruses. These inhibitors significantly reduced yields of vaccinia virus (a poxvirus, double-stranded DNA, cytoplasmic replication) and mouse hepatitis virus (a coronavirus, positive-sense single-strand RNA [ssRNA]), whereas vesicular stomatitis virus (rhabdovirus, negative-sense ssRNA) yields were unaffected. These results indicated that the activities of aurora kinases play pivotal roles in the life cycles of diverse viruses