Energetics of Eddy-Mean Flow Interactions in the Amery Ice Shelf Cavity

Previous studies demonstrated that eddy processes play an important role in ice shelf basal melting and the water mass properties of ice shelf cavities. However, the eddy energy generation and dissipation mechanisms in ice shelf cavities have not been studied systematically. The dynamic processes of the ocean circulation in the Amery Ice Shelf cavity are studied quantitatively through a Lorenz energy cycle approach for the first time by using the outputs of a high-resolution coupled regional ocean-sea ice-ice shelf model. Over the entire sub-ice-shelf cavity, mean available potential energy (MAPE) is the largest energy reservoir (112 TJ), followed by the mean kinetic energy (MKE, 70 TJ) and eddy available potential energy (EAPE, 10 TJ). The eddy kinetic energy (EKE) is the smallest pool (5.5 TJ), which is roughly 8% of the MKE, indicating significantly suppressed eddy activities by the drag stresses at ice shelf base and bottom topography. The total generation rate of available potential energy is about 1.0 GW, almost all of which is generated by basal melting and seawater refreezing, i.e., the so-called “ice pump.” The energy generated by ice pump is mainly dissipated by the ocean-ice shelf and ocean-bottom drag stresses, amounting to 0.3 GW and 0.2 GW, respectively. The EKE is generated through two pathways: the barotropic pathway MAPE→MKE→EKE (0.03 GW) and the baroclinic pathway MAPE→EAPE→EKE (0.2 GW). In addition to directly supplying the EAPE through baroclinic pathway (0.2 GW), MAPE also provides 0.5 GW of power to MKE to facilitate the barotropic pathway

An atmospheric origin of the multi-decadal bipolar seesaw

A prominent feature of recent climatic change is the strong Arctic surface warming that is contemporaneous with broad cooling over much of Antarctica and the Southern Ocean. Longer global surface temperature observations suggest that this contrasting pole-to-pole change could be a manifestation of a multi-decadal interhemispheric or bipolar seesaw pattern, which is well correlated with the North Atlantic sea surface temperature variability, and thus generally hypothesized to originate from Atlantic meridional overturning circulation oscillations. Here, we show that there is an atmospheric origin for this seesaw pattern. The results indicate that the Southern Ocean surface cooling (warming) associated with the seesaw pattern is attributable to the strengthening (weakening) of the Southern Hemisphere westerlies, which can be traced to Northern Hemisphere and tropical tropospheric warming (cooling). Antarctic ozone depletion has been suggested to be an important driving force behind the recently observed increase in the Southern Hemisphere's summer westerly winds; our results imply that Northern Hemisphere and tropical warming may have played a triggering role at an stage earlier than the first detectable Antarctic ozone depletion, and enhanced Antarctic ozone depletion through decreasing the lower stratospheric temperature

A Novel Two Mode-Acting Inhibitor of ABCG2-Mediated Multidrug Transport and Resistance in Cancer Chemotherapy

Multidrug resistance (MDR) is a major problem in successful treatment of cancers. Human ABCG2, a member of the ATP-binding cassette transporter superfamily, plays a key role in MDR and an important role in protecting cancer stem cells. Knockout of ABCG2 had no apparent adverse effect on the mice. Thus, ABCG2 is an ideal target for development of chemo-sensitizing agents for better treatment of drug resistant cancers and helping eradicate cancer stem cells.Using rational screening of representatives from a chemical compound library, we found a novel inhibitor of ABCG2, PZ-39 (N-(4-chlorophenyl)-2-[(6-{[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]amino}-1,3-benzothiazol-2-yl)sulfanyl]acetamide), that has two modes of actions by inhibiting ABCG2 activity and by accelerating its lysosome-dependent degradation. PZ-39 has no effect on ABCB1 and ABCC1-mediated drug efflux, resistance, and their expression, indicating that it may be specific to ABCG2. Analyses of its analogue compounds showed that the pharmacophore of PZ-39 is benzothiazole linked to a triazine ring backbone.Unlike any previously known ABCG2 transporter inhibitors, PZ-39 has a novel two-mode action by inhibiting ABCG2 activity, an acute effect, and by accelerating lysosome-dependent degradation, a chronic effect. PZ-39 is potentially a valuable probe for structure-function studies of ABCG2 and a lead compound for developing therapeutics targeting ABCG2-mediated MDR in combinational cancer chemotherapy

AntMan: Interactive Zero-Knowledge Proofs with Sublinear Communication

Recent works on interactive zero-knowledge (ZK) protocols provide a new paradigm with high efficiency and scalability. However, these protocols suffer from high communication overhead, often linear to the circuit size. In this paper, we proposed two new ZK protocols with communication sublinear to the circuit size, while maintaining a similar level of computational efficiency. -- We designed a ZK protocol that can prove $B$ executions of any circuit $C$ in communication $O(B + |C|)$ field elements (with free addition gates), while the best prior work requires a communication of $O(B|C|)$ field elements. Our protocol is enabled by a new tool called as information-theoretic polynomial authentication code, which may be of independent interest. -- We developed an optimized implementation of this protocol which shows high practicality. For example, with $B=2048$, $|C|=2^{20}$, and under 50 Mbps bandwidth and 16 threads, QuickSilver, a state-of-the-art ZK protocol based on vector oblivious linear evaluation (VOLE), can only prove $0.78$ million MULT gates per second (mgps) and send one field element per gate; our protocol can prove $14$ mgps ($18\times$ improvement) and send $0.0064$ field elements per gate ($156\times$ improvement) under the same hardware configuration. -- Extending the above idea, we constructed a ZK protocol that can prove a single execution of any circuit $C$ in communication $O(|C|^{3/4})$. This is the first ZK protocol with sublinear communication for an arbitrary circuit in the VOLE-based ZK family

Rapid decline of total Antarctic sea ice extent during 2014–16 controlled by wind-driven sea ice drift

Between 2014 and 2016 the annual mean total extent of Antarctic sea ice decreased by a record, unprecedented amount of 1.6 3 106 km2, the largest in a record starting in the late 1970s. The mechanisms behind such a rapid decrease remain unknown. Using the outputs of a high-resolution, global ocean–sea ice model we show that the change was predominantly a result of record atmospheric low pressure systems over sectors of the Southern Ocean in 2016, with the associated winds inducing strong sea ice drift. Regions of large positive and negative sea ice extent anomaly were generated by both thermal and dynamic effects of the wind anomalies. Although the strong wind forcing also generated the warmest ocean surface state from April to December 2016, we show that enhanced northward sea ice drift and hence increased melting at lower latitudes driven by strong winds made the dominant contribution to the large decrease in total Antarctic sea ice extent between 2014 and 2016

14-3-3σ Contributes to Radioresistance by Regulating DNA Repair and Cell Cycle via PARP1 and CHK2

14-3-3σ has been implicated in the development of chemo and radiation resistance and in poor prognosis of multiple human cancers. While it has been postulated that 14-3-3σ contributes to these resistances via inhibiting apoptosis and arresting cells in G2–M phase of the cell cycle, the molecular basis of this regulation is currently unknown. In this study, we tested the hypothesis that 14-3-3σ causes resistance to DNA-damaging treatments by enhancing DNA repair in cells arrested in G2–M phase following DNA-damaging treatments. We showed that 14-3-3σ contributed to ionizing radiation (IR) resistance by arresting cancer cells in G2–M phase following IR and by increasing non-homologous end joining (NHEJ) repair of the IR-induced DNA double strand breaks (DSB). The increased NHEJ repair activity was due to 14-3-3σ–mediated upregulation of PARP1 expression that promoted the recruitment of DNA-PKcs to the DNA damage sites for repair of DSBs. On the other hand, the increased G2–M arrest following IR was due to 14-3-3σ–induced Chk2 expression. Implications: These findings reveal an important molecular basis of 14-3-3σ function in cancer cell resistance to chemo/radiation therapy and in poor prognosis of human cancers

On the determination and simulation of seawater freezing point temperature under high pressure

At present, it is believed that the freezing point temperature of seawater is a function of salinity and pressure, and the freezing point is a key parameter in a coupled air-sea-ice system. Generally, empirical formulas or methods are used to calculate the freezing point of seawater. Especially in high-pressure situations, e.g., under a thick ice sheet or ice shelf, the pressure term must be taken into account in the determination of seawater freezing point temperature. This study summarized various methods that have been used to calculate seawater freezing point with high pressure. The methods that were employed in two ocean-ice models were also assessed. We identified the disadvantages of these methods used in these two models and addressed the corresponding uncertainties of the freezing point temperature formulas. This study provides useful information on the calculation of the freezing point temperature in numerical modeling and indicates a need to investigate the sensitivity of numerical simulations to the uncertainties in the freezing point temperature in future