Artificial Gauge Field and Quantum Spin Hall States in a Conventional Two-dimensional Electron Gas

Based on the Born-Oppemheimer approximation, we divide total electron Hamiltonian in a spinorbit coupled system into slow orbital motion and fast interband transition process. We find that the fast motion induces a gauge field on slow orbital motion, perpendicular to electron momentum, inducing a topological phase. From this general designing principle, we present a theory for generating artificial gauge field and topological phase in a conventional two-dimensional electron gas embedded in parabolically graded GaAs/In$_{x}$Ga$_{1-x}$As/GaAs quantum wells with antidot lattices. By tuning the etching depth and period of antidot lattices, the band folding caused by superimposed potential leads to formation of minibands and band inversions between the neighboring subbands. The intersubband spin-orbit interaction opens considerably large nontrivial minigaps and leads to many pairs of helical edge states in these gaps.Comment: 9 pages and 4 figure

Personalized Estimate of Chemotherapy-Induced Nausea and Vomiting: Development and External Validation of a Nomogram in Cancer Patients Receiving Highly/Moderately Emetogenic Chemotherapy.

Chemotherapy-induced nausea and vomiting (CINV) is presented in over 30% of cancer patients receiving highly/moderately emetogenic chemotherapy (HEC/MEC). The currently recommended antiemetic therapy is merely based on the emetogenic level of chemotherapy, regardless of patient's individual risk factors. It is, therefore, critical to develop an approach for personalized management of CINV in the era of precision medicine.A number of variables were involved in the development of CINV. In the present study, we pooled the data from 2 multi-institutional investigations of CINV due to HEC/MEC treatment in Asian countries. Demographic and clinical variables of 881 patients were prospectively collected as defined previously, and 862 of them had full documentation of variables of interest. The data of 548 patients from Chinese institutions were used to identify variables associated with CINV using multivariate logistic regression model, and then construct a personalized prediction model of nomogram; while the remaining 314 patients out of China (Singapore, South Korea, and Taiwan) entered the external validation set. C-index was used to measure the discrimination ability of the model.The predictors in the final model included sex, age, alcohol consumption, history of vomiting pregnancy, history of motion sickness, body surface area, emetogenicity of chemotherapy, and antiemetic regimens. The C-index was 0.67 (95% CI, 0.62-0.72) for the training set and 0.65 (95% CI, 0.58-0.72) for the validation set. The C-index was higher than that of any single predictor, including the emetogenic level of chemotherapy according to current antiemetic guidelines. Calibration curves showed good agreement between prediction and actual occurrence of CINV.This easy-to-use prediction model was based on chemotherapeutic regimens as well as patient's individual risk factors. The prediction accuracy of CINV occurrence in this nomogram was well validated by an independent data set. It could facilitate the assessment of individual risk, and thus improve the personalized management of CINV

cisPath: an R/Bioconductor package for cloud users for visualization and management of functional protein interaction networks

Background: With the burgeoning development of cloud technology and services, there are an increasing number of users who prefer cloud to run their applications. All software and associated data are hosted on the cloud, allowing users to access them via a web browser from any computer, anywhere. This paper presents cisPath, an R/Bioconductor package deployed on cloud servers for client users to visualize, manage, and share functional protein interaction networks. Results: With this R package, users can easily integrate downloaded protein-protein interaction information from different online databases with private data to construct new and personalized interaction networks. Additional functions allow users to generate specific networks based on private databases. Since the results produced with the use of this package are in the form of web pages, cloud users can easily view and edit the network graphs via the browser, using a mouse or touch screen, without the need to download them to a local computer. This package can also be installed and run on a local desktop computer. Depending on user preference, results can be publicized or shared by uploading to a web server or cloud driver, allowing other users to directly access results via a web browser. Conclusions: This package can be installed and run on a variety of platforms. Since all network views are shown in web pages, such package is particularly useful for cloud users. The easy installation and operation is an attractive quality for R beginners and users with no previous experience with cloud services.SCI(E)CPCI-S(ISTP)[email protected]

Bubble density gradient with laser detection : a wake-homing scheme for supercavitating vehicles

The poor mobility and complex target motion estimation are the two main challenges in the anti-ship attack missions of high-speed guided missiles. In this study, a new wake-homing scheme of supercavitating vehicles is proposed using the gradient wake flow phenomenon. The basic principle of the wake-homing with laser detection and the information which can be obtained are studied. According to the idiosyncrasy of laser detection, the geometrical characteristics of the vessel wake, and the bubble distribution characteristics, the three-dimensional model of bubble density gradient in horizontal plane of the maneuvering target ship wake flow is first built; the guidance law based on the gradient wake flow is designed and tested. Then, simulation results show the validity of the model wake, the guidance law based on the wake gradient information can accurately track the target. From the simulation results, we also can see that the new wake-homing scheme effectively improve the hit probability, reduce the range of loss, reduce power consumption and gentle guidance trajectory, greatly reduce the mobility requirements of the supercavitating vehicle

Saliency Driven Vasculature Segmentation with Infinite Perimeter Active Contour Model

Automated detection of retinal blood vessels plays an important role in advancing the understanding of the mechanism, diagnosis and treatment of cardiovascular disease and many systemic diseases, such as diabetic retinopathy and age-related macular degeneration. Here, we propose a new framework for precisely segmenting retinal vasculatures. The proposed framework consists of three steps. A non-local total variation model is adapted to the Retinex theory, which aims to address challenges presented by intensity inhomogeneities, and the relatively low contrast of thin vessels compared to the background. The image is then divided into superpixels, and a compactness-based saliency detection method is proposed to locate the object of interest. For better general segmentation performance, we then make use of a new infinite active contour model to segment the vessels in each superpixel. The proposed framework has wide applications, and the results show that our model outperforms its competitors

Experimental Verification of Solid-like and Fluid-like States in the Homogeneous Fluidization Regime of Geldart A Particles

The mechanisms underlying homogeneous fluidization of Geldart A particles have been debated for decades. Some ascribed the stability to interparticle forces, while others insisted a purely hydrodynamic explanation. Valverde et al. (2001) fluidized 8.53-μm (i.e., Geldart C) particles by the addition of fumed silica nanoparticles and found that even during homogeneous fluidization both solid-like and fluid-like behavior can be distinguished. However, it is still unclear whether both states exist for true Geldart A particles. In this paper, the particulate fluidization characteristics of three typical Geldart A powders were studied by camera recording, electrical capacitance tomography, and pressure fluctuation. For the first time, the existence of both a solid-like state dominated by interparticle forces and a fluid-like state dominated by fluid dynamics during homogeneous expansion of Geldart A particles was experimentally verified. Furthermore, the ability and performance of the used measurement techniques to identify different flow regimes were compared.</p