An intelligent information forwarder for healthcare big data systems with distributed wearable sensors

© 2016 IEEE. An increasing number of the elderly population wish to live an independent lifestyle, rather than rely on intrusive care programmes. A big data solution is presented using wearable sensors capable of carrying out continuous monitoring of the elderly, alerting the relevant caregivers when necessary and forwarding pertinent information to a big data system for analysis. A challenge for such a solution is the development of context-awareness through the multidimensional, dynamic and nonlinear sensor readings that have a weak correlation with observable human behaviours and health conditions. To address this challenge, a wearable sensor system with an intelligent data forwarder is discussed in this paper. The forwarder adopts a Hidden Markov Model for human behaviour recognition. Locality sensitive hashing is proposed as an efficient mechanism to learn sensor patterns. A prototype solution is implemented to monitor health conditions of dispersed users. It is shown that the intelligent forwarders can provide the remote sensors with context-awareness. They transmit only important information to the big data server for analytics when certain behaviours happen and avoid overwhelming communication and data storage. The system functions unobtrusively, whilst giving the users peace of mind in the knowledge that their safety is being monitored and analysed

An Adaptive Soft Handover Scheme Using Fuzzy Load Balancing for WCDMA Systems

In cellular systems, user distribution variations can cause load imbalance between cells. Embedding a load balancing strategy within the handover scheme means that ensuing traffic congestion can be alleviated by dynamically reallocating load between neighbouring cells. An adaptive soft handover scheme for multimedia cellular communication systems is proposed in this paper, that considers both the cell load factors as well as the pilot channel signal-to-interference-and-noise-ratio (SINR) for soft handovers. By using fuzzy principles, the soft handover thresholds and time hysteresis are adapted dependent upon the loads of the neighbouring cells. Simulation results show that the new algorithm provides improved system performance in terms of a more evenly distributed load, lower blocking probabilities and higher throughput

PROSO Toolbox: a unified protein-constrained genome-scale modelling framework for strain designing and optimization

The genome-scale metabolic model with protein constraint (PC-model) has been increasingly popular for microbial metabolic simulations. We present PROSO Toolbox, a unified and simple-to-use PC-model toolbox that takes any high-quality genome-scale metabolic reconstruction as the input. The toolbox can construct a PC-model automatically, apply various algorithms for computational strain design and simulation, and help unveil metabolism from gene expression data through a state-of-the-art OVERLAY workflow. It also has detailed tutorials and documentation for maximum accessibility to researchers from diverse backgrounds. PROSO Toolbox, tutorials, and documentation are freely available online: https://github.com/QCSB/PROSO-Toolbox.Comment: 4 pages, 1 figur

Towards offering more useful data reliably to mobile cloudfrom wireless sensor network

The integration of ubiquitous wireless sensor network (WSN) and powerful mobile cloud computing (MCC) is a research topic that is attracting growing interest in both academia and industry. In this new paradigm, WSN provides data to the cloud, and mobile users request data from the cloud. To support applications involving WSN-MCC integration, which need to reliably offer data that are more useful to the mobile users from WSN to cloud, this paper first identifies the critical issues that affect the usefulness of sensory data and the reliability of WSN, then proposes a novel WSN-MCC integration scheme named TPSS, which consists of two main parts: 1) TPSDT (Time and Priority based Selective Data Transmission) for WSN gateway to selectively transmit sensory data that are more useful to the cloud, considering the time and priority features of the data requested by the mobile user; 2) PSS (Priority-based Sleep Scheduling) algorithm for WSN to save energy consumption so that it can gather and transmit data in a more reliable way. Analytical and experimental results demonstrate the effectiveness of TPSS in improving usefulness of sensory data and reliability of WSN for WSN-MCC integration

solveME: fast and reliable solution of nonlinear ME models.

BackgroundGenome-scale models of metabolism and macromolecular expression (ME) significantly expand the scope and predictive capabilities of constraint-based modeling. ME models present considerable computational challenges: they are much (>30 times) larger than corresponding metabolic reconstructions (M models), are multiscale, and growth maximization is a nonlinear programming (NLP) problem, mainly due to macromolecule dilution constraints.ResultsHere, we address these computational challenges. We develop a fast and numerically reliable solution method for growth maximization in ME models using a quad-precision NLP solver (Quad MINOS). Our method was up to 45 % faster than binary search for six significant digits in growth rate. We also develop a fast, quad-precision flux variability analysis that is accelerated (up to 60× speedup) via solver warm-starts. Finally, we employ the tools developed to investigate growth-coupled succinate overproduction, accounting for proteome constraints.ConclusionsJust as genome-scale metabolic reconstructions have become an invaluable tool for computational and systems biologists, we anticipate that these fast and numerically reliable ME solution methods will accelerate the wide-spread adoption of ME models for researchers in these fields

Adaptations of Escherichia coli strains to oxidative stress are reflected in properties of their structural proteomes.

BACKGROUND:The reconstruction of metabolic networks and the three-dimensional coverage of protein structures have reached the genome-scale in the widely studied Escherichia coli K-12 MG1655 strain. The combination of the two leads to the formation of a structural systems biology framework, which we have used to analyze differences between the reactive oxygen species (ROS) sensitivity of the proteomes of sequenced strains of E. coli. As proteins are one of the main targets of oxidative damage, understanding how the genetic changes of different strains of a species relates to its oxidative environment can reveal hypotheses as to why these variations arise and suggest directions of future experimental work. RESULTS:Creating a reference structural proteome for E. coli allows us to comprehensively map genetic changes in 1764 different strains to their locations on 4118 3D protein structures. We use metabolic modeling to predict basal ROS production levels (ROStype) for 695 of these strains, finding that strains with both higher and lower basal levels tend to enrich their proteomes with antioxidative properties, and speculate as to why that is. We computationally assess a strain's sensitivity to an oxidative environment, based on known chemical mechanisms of oxidative damage to protein groups, defined by their localization and functionality. Two general groups - metalloproteins and periplasmic proteins - show enrichment of their antioxidative properties between the 695 strains with a predicted ROStype as well as 116 strains with an assigned pathotype. Specifically, proteins that a) utilize a molybdenum ion as a cofactor and b) are involved in the biogenesis of fimbriae show intriguing protective properties to resist oxidative damage. Overall, these findings indicate that a strain's sensitivity to oxidative damage can be elucidated from the structural proteome, though future experimental work is needed to validate our model assumptions and findings. CONCLUSION:We thus demonstrate that structural systems biology enables a proteome-wide, computational assessment of changes to atomic-level physicochemical properties and of oxidative damage mechanisms for multiple strains in a species. This integrative approach opens new avenues to study adaptation to a particular environment based on physiological properties predicted from sequence alone

Using SINR as Vertical Handoff Criteria in Multimedia Wireless Networks

In the next generation multimedia wireless network environment that consists of heterogeneous access technologies, we need to offer the end user with multimedia QoS inside each access network as well as during vertical handoff between them. The vertical handoff algorithm have to be QoS aware, which cannot be achieved by using the traditional RSS as the vertical handoff criteria. In this paper, we propose a new vertical handoff algorithm using the receiving SINR from various access networks as the handoff criteria. By converting the different receiving SINR values, the handoff algorithm can have the knowledge of achievable bandwidths from both access networks, and make handoff decisions with multimedia QoS consideration. Analysis results confirms that the new SINR based vertical handoff algorithm is able to consistently offer the end user with maximum available bandwidth during vertical handoff comparing with the RSS based vertical handoff, whose performance differs under different network conditions