Role of Nrf2 in bone metabolism

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor expressed in many cell types, including osteoblasts, osteocytes, and osteoclasts. Nrf2 has been considered a master regulator of cytoprotective genes against oxidative and chemical insults. The lack of Nrf2 can induce pathologies in multiple organs. Nrf2 deficiency promotes osteoclast differentiation and osteoclast activity, which leads to an increase in bone resorption. The role of Nrf2 in osteoblast differentiation and osteoblast activity is more complex. Nrf2 mediates anabolic effects within an ideal range. Nrf2 deletion suppresses load induced bone formation and delays fracture healing. Overall, Nrf2 plays an important role in the regulation of bone homeostasis in bone cells

Low Peak-to-Average Power Ratio FBMC-OQAM System based on Data Mapping and DFT Precoding

Filter bank multicarrier with offset quadrature amplitude modulation (FBMC-OQAM) is an alternative to OFDM for enhanced spectrum flexible usage. To reduce the peak-to-average power ratio (PAPR), DFT spreading is usually adopted in OFDM systems. However, in FBMC-OQAM systems, because the OQAM pre-processing splits the spread data into the real and imaginary parts, the DFT spreading can result in only marginal PAPR reduction. This letter proposes a novel map-DFT-spread FBMC-OQAM scheme. In this scheme, the transmitting data symbols are first mapped with a conjugate symmetry rule and then coded by the DFT. According to this method, the OQAM pre-processing can be avoided. Compared with the simple DFT-spread scheme, the proposed scheme achieves a better PAPR reduction. In addition, the effect of the prototype filter on the PAPR is studied via numerical simulation and a trade-off exists between the PAPR and out-of-band performances

Solvothermal synthesis of uniform bismuth nanospheres using poly(N-vinyl-2-pyrrolidone) as a reducing agent

Uniform bismuth nanospheres were successfully prepared from bismuth nitrate in the presence of poly(N-vinyl-2-pyrrolidone) (PVP) by solvothermal process. The product was characterized by powder X-ray diffraction, scanning electron microscopy, transmission electron microscopy, selected area electron diffraction, and energy-dispersive X-ray. PVP plays a critical role both as a reducing agent and a capping agent in the formation of bismuth nanospheres. Shape and size of bismuth nanospheres could be tuned by changing the employed PVP/bismuth salt ratio. It was also found the solvent had an effect on the morphologies of bismuth nanomaterials. The possible formation and growth mechanism of bismuth nanospheres were also discussed and proposed to explain the reduction step

An Experimental Study on Indoor Massive 3D-MIMO Channel at 30-40 GHz Band

Three-dimensional (3D) multiple-input multiple-output (MIMO) channel sounder measurements are producposed for a multi-user MIMO channel at the 30-40 GHz mm-wave band. A 3D-MIMO downlink transmissions links withto two users is considered. The measurement campaign employing a vector network analyzer (VNA) washas been performed in an indoor office scenario. Based on the measurement results, weThe characterizeations of mm-wave 3D-MIMO channels are performed in the wavenumber domain and the time domain, which are jointly analyzed via a 3D inverse fast Fourier transform (IFFT). Measurement shows that the massive 3D-MIMO has a significant improvement on resolution of multipathes beyond none-massive 3D-MIMO

Regret Theory and Equilibrium Asset Prices

Regret theory is a behavioral approach to decision making under uncertainty. In this paper we assume that there are two representative investors in a frictionless market, a representative active investor who selects his optimal portfolio based on regret theory and a representative passive investor who invests only in the benchmark portfolio. In a partial equilibrium setting, the objective of the representative active investor is modeled as minimization of the regret about final wealth relative to the benchmark portfolio. In equilibrium this optimal strategy gives rise to a behavioral asset priciting model. We show that the market beta and the benchmark beta that is related to the investor’s regret are the determinants of equilibrium asset prices. We also extend our model to a market with multibenchmark portfolios. Empirical tests using stock price data from Shanghai Stock Exchange show strong support to the asset pricing model based on regret theory

High-dimensional CoVaR risk spillover network from oil market to global stock markets—Lessons from the Kyoto Protocol

This paper explores the impact of the Kyoto Protocol by investigating the correlation and risk spillover between the crude oil market and the stock markets of 28 countries during its two commitment periods. Besides time-varying Copula-CoVaR models, the Adaptive Lasso-VAR model with oracle properties is employed in generalized variance decomposition, and a risk connectedness network is constructed to explore risk spillovers between the stock markets of various countries when the crude oil market is at risk. The results reveal positive correlations between the crude oil market and stock markets, which become weaker in the second commitment period than in the first. The crude oil market has both upside and downside spillover effects to most stock markets during both commitment periods, and the upside risk spillover effect is stronger than the downside effect. Overall, most non-signatories of the Kyoto Protocol are net receivers of risk spillovers when the crude oil market is at risk, while most signatories are net exporters of risk spillovers

White Matter Abnormalities in Major Depression: A Tract-Based Spatial Statistics and Rumination Study

Increasing evidence indicates that major depressive disorder (MDD) is usually accompanied by altered white matter in the prefrontal cortex, the parietal lobe and the limbic system. As a behavioral abnormity of MDD, rumination has been believed to be a substantial indicator of the mental state of the depressive state. So far, however, no report that we are aware of has evaluated the relationship between white matter alterations and the ruminative state. In this study, we first explored the altered white matter using a tract-based spatial statistics (TBSS) method based on diffusion tensor imaging of 19 healthy and 16 depressive subjects. We then investigated correlations between the altered white matter microstructure in the identified altered regions and the severity of ruminations measured by the ruminative response scale. Our results demonstrated altered white matter microstructure in circuits connecting the prefrontal lobe, the parietal lobe and the limbic system (p<0.005, uncorrected), findings which support previous research. More importantly, the result also indicated that a greater alteration in the white matter is associated with a more ruminative state (p<0.05, Bonferroni corrected). The detected abnormalities in the white matter should be interpreted cautiously because of the small sample size in this study. This finding supports the psychometric significance of white matter deficits in MDD