4,287 research outputs found
Numerical Test of Disk Trial Wave function for Half-Filled Landau Level
The analyticity of the lowest Landau level wave functions and the relation
between filling factor and the total angular momentum severely limits the
possible forms of trial wave functions of a disk of electrons subject to a
strong perpendicular magnetic field. For N, the number of electrons, up to 12
we have tested these disk trial wave functions for the half filled Landau level
using Monte Carlo and exact diagonalization methods. The agreement between the
results for the occupation numbers and ground state energies obtained from
these two methods is excellent. We have also compared the profile of the
occupation number near the edge with that obtained from a field-theoretical
method. The results give qualitatively identical edge profiles. Experimental
consequences are briefly discussed.Comment: To be published in Phys. Rev. B. 9 pages, 6 figure
Edge of a Half-Filled Landau Level
We have investigated the electron occupation number of the edge of a quantum
Hall (QH) droplet at using exact diagonalization technique and
composite fermion trial wavefunction. We find that the electron occupation
numbers near the edge obey a scaling behavior. The scaling result indicates the
existence of a well-defined edge corresponding to the radius of a compact
droplet of uniform filling factor 1/2. We find that the occupation number
beyond this edge point is substantial, which is qualitatively different from
the case of odd-denominator QH states. We relate these features to the
different ways in which composite fermions occupy Landau levels for odd and
even denominator states.Comment: To appear in Phys. Rev.
Strongly correlated quantum dots in weak confinement potentials and magnetic fields
We explore a strongly correlated quantum dot in the presence of a weak
confinement potential and a weak magnetic field. Our exact diagonalization
studies show that the groundstate property of such a quantum dot is rather
sensitive to the magnetic field and the strength of the confinement potential.
We have determined rich phase diagrams of these quantum dots. Some experimental
consequences of the obtained phase diagrams are discussed.Comment: 5 pages, 7 figures, new and updated figure
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Visualizing formation of the active site in the mitochondrial ribosome.
Funder: Agouron InstituteFunder: Louis-Jeantet FoundationRibosome assembly is an essential and conserved process that is regulated at each step by specific factors. Using cryo-electron microscopy (cryo-EM), we visualize the formation of the conserved peptidyl transferase center (PTC) of the human mitochondrial ribosome. The conserved GTPase GTPBP7 regulates the correct folding of 16S ribosomal RNA (rRNA) helices and ensures 2'-O-methylation of the PTC base U3039. GTPBP7 binds the RNA methyltransferase NSUN4 and MTERF4, which sequester H68-71 of the 16S rRNA and allow biogenesis factors to access the maturing PTC. Mutations that disrupt binding of their Caenorhabditis elegans orthologs to the large subunit potently activate mitochondrial stress and cause viability, development, and sterility defects. Next-generation RNA sequencing reveals widespread gene expression changes in these mutant animals that are indicative of mitochondrial stress response activation. We also answer the long-standing question of why NSUN4, but not its enzymatic activity, is indispensable for mitochondrial protein synthesis
Saponin TQL1055 adjuvant-containing vaccine confers protection upon Mycobacterium tuberculosis challenge in mice
Tuberculosis (TB), caused by the intracellular pathoge
Tumor site immune markers associated with risk for subsequent basal cell carcinomas.
BackgroundBasal cell carcinoma (BCC) tumors are the most common skin cancer and are highly immunogenic.ObjectiveThe goal of this study was to assess how immune-cell related gene expression in an initial BCC tumor biopsy was related to the appearance of subsequent BCC tumors.Materials and methodsLevels of mRNA for CD3ε (a T-cell receptor marker), CD25 (the alpha chain of the interleukin (IL)-2 receptor expressed on activated T-cells and B-cells), CD68 (a marker for monocytes/macrophages), the cell surface glycoprotein intercellular adhesion molecule-1 (ICAM-1), the cytokine interferon-γ (IFN-γ) and the anti-inflammatory cytokine IL-10 were measured in BCC tumor biopsies from 138 patients using real-time PCR.ResultsThe median follow-up was 26.6 months, and 61% of subjects were free of new BCCs two years post-initial biopsy. Patients with low CD3ε CD25, CD68, and ICAM-1 mRNA levels had significantly shorter times before new tumors were detected (p = 0.03, p = 0.02, p = 0.003, and p = 0.08, respectively). Furthermore, older age diminished the association of mRNA levels with the appearance of subsequent tumors.ConclusionsOur results show that levels of CD3ε, CD25, CD68, and ICAM-1 mRNA in BCC biopsies may predict risk for new BCC tumors
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Circulating Biomarkers to Identify Responders in Cardiac Cell therapy.
Bone marrow mononuclear cell (BM-MNC) therapy in ST-elevation acute myocardial infarction (STEMI) has no biological inclusion criteria. Here, we analyzed 63 biomarkers and cytokines in baseline plasma samples from 77 STEMI patients treated with BM-MNCs in the TIME and Late-TIME trials as well as 61 STEMI patients treated with placebo. Response to cell therapy was defined by changes in left ventricular ejection fraction, systolic/diastolic volumes, and wall motion indexes. We investigated the clinical value of circulating proteins in outcome prediction using significance testing, partial least squares discriminant analysis, and receiver operating characteristic (ROC) analysis. Responders had higher biomarker levels (76-94% elevated) than non-responders. Several biomarkers had values that differed significantly (P < 0.05) between responders and non-responders including stem cell factor, platelet-derived growth factor, and interleukin-15. We then used these lead candidates for ROC analysis and found multiple biomarkers with values areas under the curve >0.70 including interleukin 15. These biomarkers were not involved in the placebo-treated subjects suggesting that they may have predictive power. We conclude that plasma profiling after STEMI may help identify patients with a greater likelihood of response to cell-based treatment. Prospective trials are needed to assess the predictive value of the circulating biomarkers
Interacting electrons in disordered potentials: Conductance versus persistent currents
An expression for the conductance of interacting electrons in the diffusive
regime as a function of the ensemble averaged persistent current and the
compressibility of the system is presented. This expression involves only
ground-state properties of the system. The different dependencies of the
conductance and persistent current on the electron-electron interaction
strength becomes apparent. The conductance and persistent current of a small
system of interacting electrons are calculated numerically and their variation
with the strength of the interaction is compared. It is found that while the
persistent current is enhanced by interactions, the conductance is suppressed.Comment: REVTeX, 4 pages, 3 figures, all uuencoded, accepted for publication
in PR
On the character of states near the Fermi level in (Ga,Mn)As: impurity to valence band crossover
We discuss the character of states near the Fermi level in Mn doped GaAs, as
revealed by a survey of dc transport and optical studies over a wide range of
Mn concentrations. A thermally activated valence band contribution to dc
transport, a mid-infrared peak at energy hbar omega approx 200 meV in the ac-
conductivity, and the hot photoluminescence spectra indicate the presence of an
impurity band in low doped (<<1% Mn) insulating GaAs:Mn materials. Consistent
with the implications of this picture, both the impurity band ionization energy
inferred from the dc transport and the position of the mid-infrared peak move
to lower energies and the peak broadens with increasing Mn concentration. In
metallic materials with > 2% doping, no traces of Mn-related activated
contribution can be identified in dc-transport, suggesting that the impurity
band has merged with the valence band. No discrepancies with this perception
are found when analyzing optical measurements in the high-doped GaAs:Mn. A
higher energy (hbar omega approx 250 meV) mid-infrared feature which appears in
the metallic samples is associated with inter-valence band transitions. Its
red-shift with increased doping can be interpreted as a consequence of
increased screening which narrows the localized-state valence-band tails and
weakens higher energy transition amplitudes. Our examination of the dc and ac
transport characteristics of GaAs:Mn is accompanied by comparisons with its
shallow acceptor counterparts, confirming the disordered valence band picture
of high-doped metallic GaAs:Mn material.Comment: 10 pages, 12 figure
Charge Fluctuations in Quantum Point Contacts and Chaotic Cavities in the Presence of Transport
We analyze the frequency-dependent current fluctuations induced into a gate
near a quantum point contact or a quantum chaotic cavity. We use a current and
charge conserving, effective scattering approach in which interactions are
treated in random phase approximation. The current fluctuations measured at a
nearby gate, coupled capacitively to the conductor, are determined by the
screened charge fluctuations of the conductor. Both the equilibrium and the
non-equilibrium current noise at the gate can be expressed with the help of
resistances which are related to the charge dynamics on the conductor. We
evaluate these resistances for a point contact and determine their
distributions for an ensemble of chaotic cavities. For a quantum point contact
these resistances exhibit pronounced oscillations with the opening of new
channels. For a chaotic cavity coupled to one channel point contacts the charge
relaxation resistance shows a broad distribution between 1/4 and 1/2 of a
resistance quantum. The non-equilibrium resistance exhibits a broad
distribution between zero and 1/4 of a resistance quantum.Comment: 9 pages, two-column Revtex, 6 figures include
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