475 research outputs found

    Invited - Temporal information processing for in-sensor computing based on amorphous IGZO phototransistor

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    On facing the massive and unstructured data processing, it is imperative to emulate artificial neural networks with new physical hardware architectures in addition to software-based approaches, to overcome the barrier of the von Neumann bottleneck. By mimicking the human visual sensing system, the optoelectronic devices, which can perform data compression and reduce the network size through the reconstruction of input signals, are promising to develop the neuromorphic in-sensor computing for minimizing the time latency as well as improving the energy efficiency. In this work, we demonstrate an amorphous indium-gallium-zinc-oxide (a-IGZO) phototransistor with ZrOx high-k dielectric layer with distinct responses to various optical stimulation inputs. Due to the persistent photoconductivity (PPC) effect of a-IGZO after lighting, our device is able to exhibit synaptic functions via the application of 405 nm light spikes, such as paired-pulse facilitation (PPF) and short-term memory (STM). Furthermore, in order to perform the temporal optical signals processing, the a-IGZO phototransistor is stimulated by four-timeframe temporal pulse streams composed of 405 nm light spikes and it expresses the different temporal responses. The distinct output photocurrent response reveals that the a-IGZO phototransistor can be applied to distinguish the time-series input light signals. Accordingly, the a-IGZO phototransistor have a promising potential for processing optical temporal information and can possibly be implemented for visual in-sensor computing techniques. Please click Download on the upper right corner to see the full abstract

    Luteolin Suppresses Inflammatory Mediator Expression by Blocking the Akt/NFκB Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice

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    Acute lung injury (ALI), instilled by lipopolysaccharide (LPS), is a severe illness with excessive mortality and has no specific treatment strategy. Luteolin is an anti-inflammatory flavonoid and widely distributed in the plants. Pretreatment with luteolin inhibited LPS-induced histological changes of ALI and lung tissue edema. In addition, LPS-induced inflammatory responses, including increased vascular permeability, tumor necrosis factor (TNF)-α and interleukin (IL)-6 production, and expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), were also reduced by luteolin in a concentration-dependent manner. Furthermore, luteolin suppressed activation of NFκB and its upstream molecular factor, Akt. These results suggest that the protection mechanism of luteolin is by inhibition of NFκB activation possibly via Akt

    Unusual dyspnea in a hemodialysis patient: A case report

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    The typical clinical symptoms of hemothorax include a rapid development of chest pain or dyspnea, which may be life-threatening without immediate management. As we know, spontaneous hemothorax, a collection of blood within the pleural cavity without previous history of trauma or other cause, which usually onsets suddenly. The early and accurate diagnosis of spontaneous hemothorax is imperative in clinical practice. We reported a middle-age male undergoing regular hemodialysis was referred to our emergency department due to unknown cause of dyspnea and acute respiratory failure. Chest radiography revealed bilateral patchy infiltration of lung. Pleural tap analysis showed exudative pleural effusion with numerous red blood cells. Video-assisted thoracic surgery (VATS) were performed and confirmed the final diagnosis of spontaneous hemothorax. He was then successfully treated with the surgery of VATS combined chest tube thoracostomy

    Simple Yet Powerful Native Language Identification on TOEFL11

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    Abstract Native language identification (NLI) is the task to determine the native language of the author based on an essay written in a second language. NLI is often treated as a classification problem. In this paper, we use the TOEFL11 data set which consists of more data, in terms of the amount of essays and languages, and less biased across prompts, i.e., topics, of essays. We demonstrate that even using word level n-grams as features, and support vector machine (SVM) as a classifier can yield nearly 80% accuracy. We observe that the accuracy of a binary-based word level ngram representation (~80%) is much better than the performance of a frequency-based word level n-gram representation (~20%). Notably, comparable results can be achieved without removing punctuation marks, suggesting a very simple baseline system for NLI

    SMILEtrack: SiMIlarity LEarning for Occlusion-Aware Multiple Object Tracking

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    Despite recent progress in Multiple Object Tracking (MOT), several obstacles such as occlusions, similar objects, and complex scenes remain an open challenge. Meanwhile, a systematic study of the cost-performance tradeoff for the popular tracking-by-detection paradigm is still lacking. This paper introduces SMILEtrack, an innovative object tracker that effectively addresses these challenges by integrating an efficient object detector with a Siamese network-based Similarity Learning Module (SLM). The technical contributions of SMILETrack are twofold. First, we propose an SLM that calculates the appearance similarity between two objects, overcoming the limitations of feature descriptors in Separate Detection and Embedding (SDE) models. The SLM incorporates a Patch Self-Attention (PSA) block inspired by the vision Transformer, which generates reliable features for accurate similarity matching. Second, we develop a Similarity Matching Cascade (SMC) module with a novel GATE function for robust object matching across consecutive video frames, further enhancing MOT performance. Together, these innovations help SMILETrack achieve an improved trade-off between the cost ({\em e.g.}, running speed) and performance (e.g., tracking accuracy) over several existing state-of-the-art benchmarks, including the popular BYTETrack method. SMILETrack outperforms BYTETrack by 0.4-0.8 MOTA and 2.1-2.2 HOTA points on MOT17 and MOT20 datasets. Code is available at https://github.com/pingyang1117/SMILEtrack_Officia

    Non-leisure time physical activity is an independent predictor of longevity for a Taiwanese elderly population: an eight-year follow-up study

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    <p>Abstract</p> <p>Background</p> <p>The aim of this study is to determine the relationship between leisure time physical activity (LTPA) and non-leisure time physical activity (NLTPA) on mortality among the elderly in Taiwan.</p> <p>Methods</p> <p>This is a prospective observational cohort study. We analyzed the mortality data from a cohort of 876 non-institutionalized community-dwelling men and women aged 65 years or over, who were recruited by stratified clustering random sampling from Tainan city and participated in the 1996 Elderly Medication Survey. Information about activities and other variables were collected by structured interviews at baseline in the participants' home. The Cox proportional hazards model and crude death rate were applied to estimate mortality risk.</p> <p>Results</p> <p>Among the 876 participants, 312 died during the follow-up period (1996-2004). In the unadjusted Cox regression model, subjects aged over 75, having difficulty in carrying out activities of daily living (ADLs), a BMI less than 18.5, a history of diabetes mellitus or stroke, without LTPA or being inactive in NLTPA, were found to have a higher risk of eight-year mortality. With the adjustment for age, gender, education level, habitual smoking and drinking, living status, BMI and medical history, the mortality was found to be higher among the sedentary subjects, either defined by lack of LTPA or NLTPA, with the hazard ratio of 1.27 (95% confidence interval [CI] = 0.97-1.66) and 1.45 (95% CI = 1.07-1.97), respectively. Furthermore, when both LTPA and NLTPA were put into the model simultaneously, NLTPA (HR = 1.40; 95% CI = 1.03-1.91) but not LTPA (HR = 1.21, 95% CI = 0.92-1.59) significantly predicted mortality during eight-year follow-up. In addition, subjects who were actively engaged in NLTPA had a lower mortality risk especially in subjects without performing LTPA.</p> <p>Conclusions</p> <p>NLTPA is an independent predictor of longevity among older people in Taiwan. A physically active lifestyle, especially engaged in NLTPA, is associated with lower mortality risk in the elderly population. We thus suggest that encouraging older people to keep on engaging in customary NLTPA is good for their health.</p

    Production of Active Nonglycosylated Recombinant B-Chain of Type-2 Ribosome-Inactivating Protein from Viscum articulatum and Its Biological Effects on Peripheral Blood Mononuclear Cells

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    Type-2 ribosome-inactivating proteins, composed of a toxic A-chain and lectin-like B-chain, display various biological functions, including cytotoxicity and immunomodulation. We here cloned the lectin-like B-chain encoding fragment of a newly identified type-2 RIP gene, articulatin gene, from Viscum articulatum, into a bacterial expression vector to obtain nonglycosylated recombinant protein expressed in inclusion bodies. After purification and protein refolding, soluble refolded recombinant articulatin B-chain (rATB) showed lectin activity specific toward galactoside moiety and was stably maintained while stored in low ionic strength solution. Despite lacking glycosylation, rATB actively bound leukocytes with preferential binding to monocytes and in vitro stimulated PBMCs to release cytokines without obvious cytotoxicity. These results implicated such a B-chain fragment as a potential immunomodulator
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