Protecting web services with service oriented traceback architecture

Service oriented architecture (SOA) is a way of reorganizing software infrastructure into a set of service abstracts. In the area of applying SOA to Web service security, there have been some well defined security dimensions. However, current Web security systems, like WS-Security are not efficient enough to handle distributed denial of service (DDoS) attacks. Our new approach, service oriented traceback architecture (SOTA), provides a framework to be able to identify the source of an attack. This is accomplished by deploying our defence system at distributed routers, in order to examine the incoming SOAP messages and place our own SOAP header. By this method, we can then use the new SOAP header information, to traceback through the network the source of the attack. According to our experimental performance evaluations, we find that SOTA is quite scaleable, simple and quite effective at identifying the source.<br /

The effects of reading app usage on reading comprehension

This research study was carried out to explore the relationship between reading app use and the reading comprehension of kindergarteners. There were three participants in this study who were all kindergarteners in my classroom. Their ages ranged from five to six years old and all were high-level learners. Compared to the other students in the classroom, these three students were among the most advanced readers. A five-week long reading enrichment plan using a reading app for the iPad was conducted to examine how it would affect the three students’ reading comprehension. The reading app, called Booksy, was used in addition to the core literacy instruction provided in my classroom. While the results from this study do not support the importance of using a reading app for improving kindergarten reading comprehension, it does not discount the usefulness of reading apps completely

Worm House

WORM HOUSE is a weekly zine I make; it contains original diaristic brain regurgitation.https://digital.kenyon.edu/covid19words/1063/thumbnail.jp

Defending grid web services from XDoS attacks by SOTA

Grid Web Services are still relevantly a new to business systems, and as more systems are being attached to it, any threat to it could bring collapse and huge harm. Some of these potential threats to Grid Web services come in a new form of a new denial of service attack (DoS), called XML Denial of Service or XDOS attacks. Though, as yet, there have not been any reported attacks from the media, we have observed these attacks are actually far less complex to implement than any previous Denial of Service (DoS), but still just as affective. Current security applications for grid web services (WS-Security for example), based on our observations, and are not up to job of handling the problem. In this paper, we build on our previous work called Service Oriented Traceback Architecture (SOTA), and apply our model to Grid Networks that employ web services. We further introduce a filter defence system, called XDetector, to work in combination with SOTA. Our results show that SOTA in conjunction with XDetector makes for an effective defence against XDoS attacks and upcoming DXDoS.<br /

Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function.

The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood. Mature AgRP(83-132) has distinct residues for melanocortin receptor binding and heparan sulfate interactions. Here, we show that AgRP increases ad libitum feeding and operant responding for food in mice, decreases oxygen consumption, and lowers body temperature and activity, indicating lower energy expenditure. AgRP increased the respiratory exchange ratio, indicating a reduction of fat oxidation and a shift toward carbohydrates as the primary fuel source. The duration and intensity of AgRP's effects depended on the density of its positively charged amino acids, suggesting that its orexigenic and metabolic effects depend on its affinity for heparan sulfate. These findings may have major clinical implications by unveiling the critical involvement of interactions between AgRP and heparan sulfate to the central regulation of energy expenditure, fat utilization, and possibly their contribution to metabolic disease

The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes.

Evenly spaced nucleosomes directly correlate with condensed chromatin and gene silencing. The ATP-dependent chromatin assembly factor (ACF) forms such structures in vitro and is required for silencing in vivo. ACF generates and maintains nucleosome spacing by constantly moving a nucleosome towards the longer flanking DNA faster than the shorter flanking DNA. How the enzyme rapidly moves back and forth between both sides of a nucleosome to accomplish bidirectional movement is unknown. Here we show that nucleosome movement depends cooperatively on two ACF molecules, indicating that ACF functions as a dimer of ATPases. Further, the nucleotide state determines whether the dimer closely engages one or both sides of the nucleosome. Three-dimensional reconstruction by single-particle electron microscopy of the ATPase-nucleosome complex in an activated ATP state reveals a dimer architecture in which the two ATPases face each other. Our results indicate a model in which the two ATPases work in a coordinated manner, taking turns to engage either side of a nucleosome, thereby allowing processive bidirectional movement. This novel dimeric motor mechanism differs from that of dimeric motors such as kinesin and dimeric helicases that processively translocate unidirectionally and reflects the unique challenges faced by motors that move nucleosomes

Memantine Improves Attentional Processes in Fragile X-Associated Tremor/Ataxia Syndrome: Electrophysiological Evidence from a Randomized Controlled Trial.

Progressive cognitive deficits are common in patients with fragile X-associated tremor/ataxia syndrome (FXTAS), with no targeted treatment yet established. In this substudy of the first randomized controlled trial for FXTAS, we examined the effects of NMDA antagonist memantine on attention and working memory. Data were analyzed for patients (24 in each arm) who completed both the primary memantine trial and two EEG recordings (at baseline and follow-up) using an auditory "oddball" task. Results demonstrated significantly improved attention/working memory performance after one year only for the memantine group. The event-related potential P2 amplitude elicited by non-targets was significantly enhanced in the treated group, indicating memantine-associated improvement in attentional processes at the stimulus identification/discrimination level. P2 amplitude increase was positively correlated with improvement on the behavioral measure of attention/working memory during target detection. Analysis also revealed that memantine treatment normalized the P2 habituation effect at the follow-up visit. These findings indicate that memantine may benefit attentional processes that represent fundamental components of executive function/dysfunction, thought to comprise the core cognitive deficit in FXTAS. The results provide evidence of target engagement of memantine, as well as therapeutically relevant information that could further the development of specific cognitive or disease-modifying therapies for FXTAS