S-4-Chloro­phenyl 9,10-dihydro­acridine-9-carbothio­ate

In tricyclic fragment of the title mol­ecule, C20H14ClNOS, the central 1,4-dihydro­pyridine ring adopts a boat conformation while the two benzene rings form a dihedral angle of 17.38 (5)°. In the crystal structure, weak inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into chains propagating along the b axis

Inguinal draining-lymph node in 18F-FDG PET/CT images could be a new indicator for the diagnosis of fracture-related infection in the lower extremities

PurposeThe imaging diagnosis of fracture-related infection is often challenging. The aim of this study was to evaluate the value of 18F-FDG PET/CT for the diagnosis of fracture-related infection (FRI) with internal fixation after orthopedic surgery in lower extremities.MethodsA total of 254 consecutive patients who underwent 18F-FDG PET/CT scans with suspected FRI with internal fixation in lower extremities were retrospectively investigated 18F-FDG PET/CT images were semiquantitatively evaluated with multiple metabolic parameters. Additionally, morphological information of the inguinal draining lymph nodes (DLN) with the highest SUV value was also collected and analyzed.ResultsPatients were divided into two groups according to final diagnosis: the infected (N=197) and the non-infected group (N=57). The differences in the inguinal DLN-related parameters, including the long diameter, short diameter, maximum cross-sectional area, maximum standardized uptake value (SUVmax), metabolic volume (MV) 60%, MV70%, MV80%, total lesional glycolysis (TLG) 60%, TLG70%, TLG80%, and the infection suspected area related parameters, including SUVmax, MV25%, MV30%, MV35%, MV40%, MV50%, and TLG70%, between the two groups were statistically significant. We then compared the highest area under the curves (AUCs) among the morphological parameters of DLN, metabolic parameters of DLN, and metabolic parameters of the suspected infection area. The result demonstrated that SUVmax of the inguinal DLN showed the best diagnostic performance with an AUC of 0.939 (P<0.05).ConclusionSemiquantitative analysis (especially SUVmax) of the inguinal DLN in 18F-FDG PET/CT images could be a promising method for the diagnosis of suspected FRI with internal fixation after orthopedic surgery in lower extremities

A Novel Multiple Attribute Satisfaction Evaluation Approach with Hesitant Intuitionistic Linguistic Fuzzy Information

This paper investigates the multiple attribute decision making (MADM) problems in which the attribute values take the form of hesitant intuitionistic linguistic fuzzy element (HILFE). Firstly, motivated by the idea of intuitionistic linguistic variables (ILVs) and hesitant fuzzy elements (HFEs), the concept, operational laws, and comparison laws of HILFE are defined. Then, some aggregation operators are developed for aggregating the hesitant intuitionistic linguistic fuzzy information, such as hesitant intuitionistic linguistic fuzzy weighted aggregation operators, hesitant intuitionistic linguistic fuzzy ordered weighted aggregation operators, and generalized hesitant intuitionistic linguistic fuzzy weighted aggregation operators. Moreover, some desirable properties of these operators and the relationships between them are discussed. Based on the hesitant intuitionistic linguistic fuzzy weighted average (HILFWA) operator and the hesitant intuitionistic linguistic fuzzy weighted geometric (HILFWG) operator, an approach for evaluating satisfaction degree is proposed under hesitant intuitionistic linguistic fuzzy environment. Finally, a practical example of satisfaction evaluation for milk products is given to illustrate the application of the proposed method and to demonstrate its practicality and effectiveness

Inter-comparison and evaluation of Arctic sea ice type products

oai:publications.copernicus.org:tc102910Arctic sea ice type (SITY) variation is a sensitive indicator of climate change. However, systematic inter-comparison and analysis for SITY products are lacking. This study analysed eight daily SITY products from five retrieval approaches covering the winters of 1999–2019, including purely radiometer-based (C3S-SITY), scatterometer-based (KNMI-SITY and IFREMER-SITY) and combined ones (OSISAF-SITY and Zhang-SITY). These SITY products were inter-compared against a weekly sea ice age product (i.e. NSIDC-SIA – National Snow and Ice Data Center sea ice age) and evaluated with five synthetic aperture radar (SAR) images. The average Arctic multiyear ice (MYI) extent difference between the SITY products and NSIDC-SIA varies from -1.32×106 to 0.49×106 km2. Among them, KNMI-SITY and Zhang-SITY in the QuikSCAT (QSCAT) period (2002–2009) agree best with NSIDC-SIA and perform the best, with the smallest bias of -0.001×106 km2 in first-year ice (FYI) extent and -0.02×106 km2 in MYI extent. In the Advanced Scatterometer (ASCAT) period (2007–2019), KNMI-SITY tends to overestimate MYI (especially in early winter), whereas Zhang-SITY and IFREMER-SITY tend to underestimate MYI. C3S-SITY performs well in some early winter cases but exhibits large temporal variabilities like OSISAF-SITY. Factors that could impact performances of the SITY products are analysed and summarized. (1) The Ku-band scatterometer generally performs better than the C-band scatterometer for SITY discrimination, while the latter sometimes identifies FYI more accurately, especially when surface scattering dominates the backscatter signature. (2) A simple combination of scatterometer and radiometer data is not always beneficial without further rules of priority. (3) The representativeness of training data and efficiency of classification are crucial for SITY classification. Spatial and temporal variation in characteristic training datasets should be well accounted for in the SITY method. (4) Post-processing corrections play important roles and should be considered with caution.</p

Simultaneous conversion of all cell wall components by an oleaginous fungus without chemi-physical pretreatment

Lignin utilization during biomass conversion has been a major challenge for lignocellulosic biofuel. In particular, the conversion of lignin along with carbohydrate for fungible fuels and chemicals will both improve the overall carbon efficiency and reduce the need for chemical pretreatments. However, few biomass-converting microorganisms have the capacity to degrade all cell wall components including lignin, cellulose, and hemicellulose. We hereby evaluated a unique oleaginous fungus strain, Cunninghamella echinulata FR3, for its capacity to degrade lignin during biomass conversion to lipid, and the potential to carry out consolidated fermentation without chemical pretreatment, especially when combined with sorghum (Sorghum bicolor) bmr mutants with reduced lignin content. The study clearly showed that lignin was consumed together with carbohydrate during biomass conversion for all sorghum samples, which indicates that this organism has the potential for biomass conversion without chemical pretreatment. Even though dilute acid pretreatment of biomass resulted in more weight loss during fungal fermentation than untreated biomass, the lipid yields were comparable for untreated bmr6/bmr12 double mutant and dilute acid-pretreated wild-type biomass samples. The mechanisms for lignin degradation in oleaginous fungi were further elucidated through transcriptomics and chemical analysis. The studies showed that in C. echinulata FR3, the Fenton reaction may play an important role in lignin degradation. This discovery is among the first to show that a mechanism for lignin degradation similar to those found in white and brown rot basidiomycetous fungi exists in an oleaginous fungus. This study suggests that oleaginous fungi such as C. echinulata FR3 can be employed for complete biomass utilization in a consolidated platform without chemical pretreatment or can be used to convert lignin waste into lipids

Magnetic-field-induced electronic instability of Weyl-like fermions in compressed black phosphorus

Revealing the role of Coulomb interaction in topological semimetals with Dirac/Weyl-like band dispersion shapes a new frontier in condensed matter physics. Topological node-line semimetals (TNLSMs), anticipated as a fertile ground for exploring electronic correlation effects due to the anisotropy associated with their node-line structure, have recently attracted considerable attention. In this study, we report an experimental observation for correlation effects in TNLSMs realized by black phosphorus (BP) under hydrostatic pressure. By performing a combination of nuclear magnetic resonance measurements and band calculations on compressed BP, a magnetic-field-induced electronic instability of Weyl-like fermions is identified under an external magnetic field parallel to the so-called nodal ring in the reciprocal space. Anomalous spin fluctuations serving as the fingerprint of electronic instability are observed at low temperatures, and they are observed to maximize at approximately 1.0 GPa. This study presents compressed BP as a realistic material platform for exploring the rich physics in strongly coupled Weyl-like fermions.Comment: 10 pages, 4 figure

Investigation on Photovoltaic Performance based on Matchstick-Like Cu2S–In2S3Heterostructure Nanocrystals and Polymer

In this paper, we synthesized a novel type II cuprous sulfide (Cu2S)–indium sulfide (In2S3) heterostructure nanocrystals with matchstick-like morphology in pure dodecanethiol. The photovoltaic properties of the heterostructure nanocrystals were investigated based on the blends of the nanocrystals and poly(2-methoxy-5-(2′-ethylhexoxy)-p-phenylenevinylene) (MEH-PPV). In comparison with the photovoltaic properties of the blends of Cu2S or In2S3nanocrystals alone and MEH-PPV, the power conversion efficiency of the hybrid device based on blend of Cu2S–In2S3and MEH-PPV is enhanced by ~3–5 times. This improvement is consistent with the improved exciton dissociation or separation and better charge transport abilities in type II heterostructure nanocrystals

Feasibility analysis of sentinel lymph node biopsy in breast cancer with axilla negative evaluation by physical examination but suspicious lymph nodes finding on preoperative imaging and metastasis confirmed with biopsy

Background and purpose: With the increasing sensitivity of axillary imaging and ultrasound guided biopsy, some clinically axillary negative patients were upstaged to axillary positive (cN1) and received axillary lymph node dissection (ALND). This study aimed to assess the feasibility of sentinel lymph node (SLN) biopsy (SLNB) in patients with axilla negative evaluation by physical examination but suspicious lymph nodes finding on preoperative imaging and metastasis confirmed with a fine-needle aspiration cytology/core-needle biopsy pathology (FNAC/CNBP). Methods: This retrospective cohort study included patients with early breast cancer who had axilla negative evaluation by physical examination but suspicious lymph nodes finding on preoperative imaging and metastasis confirmed with a FNAC/CNBP from October 2015 to December 2022 in the Breast Cancer Centre of Shandong Cancer Hospital and Institute. All patients received ALND. The data were analyzed by using SPSS version 27.0 statistical software, and P&lt;0.05 was considered statistically significant. Results: A total of 158 patients were identified to have axilla negative evaluation by physical examination but one to two suspicious lymph nodes finding on preoperative imaging and metastasis confirmed with FNAC/CNBP, 43.7% (69/158) of them had only one ALN metastasis after ALND, 15.2% (24/158) had only two ALNs metastases after ALND, and 41.1% (65/158) had more than two ALNs metastases after ALND. Among these cases, 65 patients received SLNB followed by ALND, and the false negative rate of SLNB was 0%. Positive non-SLN metastasis rate was 0 in the 61.5% (40/65) patients with 1-2 positive SLNs metastasis. One, two, three and more than three non-SLN metastasis rates were 10.8% (7/65), 4.6% (3/65), 6.2% (4/65) and 16.9% (11/65), respectively (P=0.042). Conclusion: SLNB was safe and feasible in patients with axilla negative evaluation by physical examination but one to two suspicious lymph nodes finding on preoperative imaging and metastasis confirmed with a FNAC/CNBP. In these patients, the axillary lymph node tumor burden was high, and exhaustive radiotherapy and systematic treatment were needed to control reginal disease

Impact of biogenic SOA loading on the molecular composition of wintertime PM2.5 in urban Tianjin: an insight from Fourier transform ion cyclotron resonance mass spectrometry

Biomass burning is one of the key sources of urban aerosols in the North China Plain, especially in winter when the impact of secondary organic aerosols (SOA) formed from biogenic volatile organic compounds (BVOCs) is generally considered to be minor. However, little is known about the influence of biogenic SOA loading on the molecular composition of wintertime organic aerosols. Here, we investigated the water-soluble organic compounds in fine particles (PM2.5) from urban Tianjin by ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Our results show that most of the CHO and CHON compounds were derived from biomass burning; they contain O-poor and highly unsaturated compounds with aromatic rings, which are sensitive to photochemical reactions, and some of which probably contribute to light-absorbing chromophores. Under moderate to high SOA loading conditions, the nocturnal chemistry is more efficient than photooxidation to generate secondary CHO and CHON compounds with high oxygen content. Under low SOA-loading, secondary CHO and CHON compounds with low oxygen content are mainly formed by photochemistry. Secondary CHO compounds are mainly derived from oxidation of monoterpenes. But nocturnal chemistry may be more productive to sesquiterpene-derived CHON compounds. In contrast, the number- and intensity-weight of S-containing groups (CHOS and CHONS) increased significantly with the increase of biogenic SOA-loading, which agrees with the fact that a majority of the S-containing groups are identified as organosulfates and nitrooxy-organosulfates that are derived from the oxidation of BVOCs. Terpenes may be potential major contributors to the chemical diversity of organosulfates and nitrooxy-organosulfates under photo-oxidation. While the nocturnal chemistry is more beneficial to the formation of organosulfates and nitrooxy-organosulfates under low SOA-loading. The SOA-loading is an important factor associating with the oxidation degree, nitrate group content and chemodiversity of nitrooxy-organosulfates. Furthermore, our study suggests that the hydrolysis of nitrooxy-organosulfates is a possible pathway for the formation of organosulfates.</p