13-Moment System with Global Hyperbolicity for Quantum Gas

We point out that the quantum Grad's 13-moment system [R. Yano, Physica A: Statistical Mechanics and its Applications, 416:231-241, 2014] is lack of global hyperbolicity, and even worse, the thermodynamic equilibrium is not an interior point of the hyperbolicity region of the system. To remedy this problem, by fully considering Grad's expansion, we split the expansion into the equilibrium part and the non-equilibrium part, and propose a regularization for the system with the help of the new theory developed in [Z. Cai et al., SIAM J. Appl. Math., 75(5):2001-2023, 2015, Y. Fan, J. Stat. Phys., 161(4), 2015]. This provides us a new model which is hyperbolic for all admissible thermodynamic states, and meanwhile preserves the approximate accuracy of the original system. It should be noted that this procedure is not a trivial application of the theory in [Z. Cai et al., SIAM J. Appl. Math., 75(5):2001-2023, 2015, Y. Fan, J. Stat. Phys., 161(4), 2015].Comment: 23 pages and 12 figure

Current Art Human Resources Development and Management of Problems and Solutions

Factor analysis, correlation analysis, modeling, network analysis and other analytical methods and theory with practice and the ideological line of the relevant statistical data, information and computer technology combine to explore the current impact of human resource development and use of art elements such as ideology and understanding of the barriers, barriers in theory, system, structure, and mechanism of the barriers, art education and creative talent, Scientific research, barriers, human capital aspects of art and other barriers. Impact of art on human resources development and utilization factors based on in-depth analysis, from the innovative thinking, artistic personnel training, personnel quality art education, art human resources management, incentive mechanisms, so some countermeasures and suggestions. And reached the following conclusion: only continue to explore, find and improve the current art human resources development and utilization of new methods, new measures in order to truly establish the characteristics of human resources meet the art human resources management system.Key words: Art talent; Constraints; Suggestion

HSP27 Alleviates Cardiac Aging in Mice via a Mechanism Involving Antioxidation and Mitophagy Activation

Aging-induced cardiac dysfunction is a prominent feature of cardiac aging. Heat shock protein 27 (HSP27) protects cardiac function against ischemia or chemical challenge. We hypothesized that HSP27 attenuates cardiac aging. Transgenic (Tg) mice with cardiac-specific expression of the HSP27 gene and wild-type (WT) littermates were employed in the experiments. Echocardiography revealed a significant decline in the cardiac function of old WT mice compared with young WT mice. In striking contrast, the aging-induced impairment of cardiac function was attenuated in old Tg mice compared with old WT mice. Levels of cardiac aging markers were lower in old Tg mouse hearts than in old WT mouse hearts. Less interstitial fibrosis and lower contents of reactive oxygen species and ubiquitin-conjugated proteins were detected in old Tg hearts than in old WT hearts. Furthermore, old Tg hearts demonstrated lower accumulation of LC3-II and p62 than old WT hearts. Levels of Atg13, Vps34, and Rab7 were also higher in old Tg hearts than in old WT hearts. Additionally, old Tg hearts had higher levels of PINK1 and Parkin than old WT hearts, suggesting that mitophagy was activated in old Tg hearts. Taken together, HSP27 alleviated cardiac aging and this action involved antioxidation and mitophagy activation

Continuous variable entanglement enhancement and manipulation by a sub-threshold type-II optical parametric amplifier

We experimentally demonstrate that the quantum entanglement between amplitude and phase quadratures of optical modes produced from a non-degenerate optical parametric amplifier (NOPA) can be enhanced and manipulated phase-sensitively by means of another NOPA. When both NOPAs operate at de-amplification, the entanglement degree is increased at the cavity resonance of the second NOPA. When the first NOPA operates at de-amplification and the second one at amplification, the spectral features of the correlation variances are significantly changed. The experimental results are in good agreement with the theoretical expectation

HSPA12B Attenuated Acute Myocardial Ischemia/reperfusion Injury via Maintaining Endothelial Integrity in a PI3K/Akt/mTOR-dependent Mechanism

Endothelial damage is a critical mediator of myocardial ischemia/reperfusion (I/R) injury. HSPA12B is an endothelial-cell-specifically expressed heat shock protein. However, the roles of HSPA12B in acute myocardial I/R injury is unknown. Here we reported that myocardial I/R upregulated HSPA12B expression in ventricular tissues, and endothelial overexpression of HSPA12B in transgenic mice (Tg) limited infarct size, attenuated cardiac dysfunction and improved cardiomyocyte survival compared with their wild type littermates. These improvements were accompanied with the diminished myocardial no-reflow phenomenon, decreased microvascular leakage, and better maintained endothelial tight junctions. The I/R-evoked neutrophil infiltration was also suppressed in Tg hearts compared with its wild type (WT) littermates. Moreover, Tg hearts exhibited the enhanced activation of PI3K/Akt//mTOR signaling following I/R challenge. However, pharmacological inhibition of PI3K abolished the HSPA12B-induced cardioprotection against myocardial I/R injury. The data demonstrate for the first time that the endothelial HSPA12B protected hearts against myocardial I/R injury. This cardioprotective action of HSPA12B was mediated, at least in part, by improving endothelial integrity in a PI3K/Akt/mTOR-dependent mechanism. Our study suggests that targeting endothelial HSPA12B could be an alternative approach for the management of patients with myocardial I/R injury