(±)-Aspongamide A, an <i>N</i>‑Acetyldopamine Trimer Isolated from the Insect <i>Aspongopus chinensis,</i> Is an Inhibitor of p‑Smad3

(±)-Aspongamide A (<b>1</b>), an unusual trimer of <i>N</i>-acetyldopamine (NADA) bearing a novel tetrahydrobenzo­[<i>a</i>]­dibenzo­[<i>b</i>,<i>e</i>]­[1,4]­dioxine structure, and a pair of NADA dimeric enantiomers (<b>2</b>) were isolated from <i>Aspongopus chinensis</i>. The structures of compounds <b>1</b> and <b>2</b> were assigned using spectroscopic methods. Compound <b>1</b> was found to be an inhibitor of Smad3 phosphorylation in transforming growth factor-β1 (TGF-β1) induced rat renal proximal tubular cells and suppressed extracellular matrix expression in mesangial cells under diabetic conditions

Supplementary material for: Metabolomics-based chemotaxonomy of root endophytic fungi for natural products discovery

Supplementary files for Maciá-Vicente et al. (2018) Metabolomics-based chemotaxonomy of root endophytic fungi for natural products discovery. Environmental Microbiology, doi: 10.1111/1462-2920.1407

Chemical constituents from <i>Piper wallichii</i>

<div><p>Fifteen known compounds including four triterpenoids (<b>1</b>–<b>4</b>), one sterol (<b>5</b>), one diketopiperazine alkaloid (<b>6</b>) and nine phenolics (<b>7</b>–<b>15</b>) were isolated from the stems of <i>Piper wallichii</i>. Their structures were elucidated by means of spectroscopic analysis, and acidic hydrolysis in case of the 2-oxo-3β,19α,23-trihydroxyurs-12-en-28-oic acid β-D-glucopyranosyl ester (<b>1</b>). The structure of compound <b>1</b> was fully assigned by 1D and 2D NMR experiments for the first time. All isolates were tested for their antibacterial, antifungal, anti-inflammatory and antiplatelet aggregation bioactivities.</p></div