Effectiveness and cost-effectiveness of transmural collaborative care with consultation letter (TCCCL) and duloxetine for major depressive disorder (MDD) and (sub)chronic pain in collaboration with primary care: design of a randomized placebo-controlled multi-Centre trial: TCC:PAINDIP

__Abstract__ Background: The comorbidity of pain and depression is associated with high disease burden for patients in terms of disability, wellbeing, and use of medical care. Patients with major and minor depression often present themselves with pain to a general practitioner and recognition of depression in such cases is low, but evolving. Also, physical symptoms, including pain, in major depressive disorder, predict a poorer response to treatment. A multi-faceted, patient-tailored treatment programme, like collaborative care, is promising. However, treatment of chronic pain conditions in depressive patients has, so far, received limited attention in research. Cost effectiveness of an integrated approach of pain in depressed patients has not been studied. This article describes the aims and design of a study to evaluate effects and costs of collaborative care with the antidepressant duloxetine for patients with pain symptoms and a depressive disorder, compared to collaborative care with placebo and compared to duloxetine alone

J. Vac. Sci. Technol. B

The formation of regular nanostructures by photopolymerization of three diolefin derivative crystals, P2VB, DSP, and p-CPAEt is investigated using atomic force microscopy (AFM) and known crystal packing data. AFM reveals that the crystal face (100) and (010) of P2VB exhibit volcanoes, whereas (100) and (010) of DSP give floelike structures. The main face and long side face of p-CPAEt give rise to volcanoes. All of those are guided by the crystal structure. Molecular interpretations of the AFM features of P2VB and DSP are given. (C) 1999 American Vacuum Society. [S0734-211X(99)03606-9].The formation of regular nanostructures by photopolymerization of three diolefin derivative crystals, P2VB, DSP, and p-CPAEt is investigated using atomic force microscopy (AFM) and known crystal packing data. AFM reveals that the crystal face (100) and (010) of P2VB exhibit volcanoes, whereas (100) and (010) of DSP give floelike structures. The main face and long side face of p-CPAEt give rise to volcanoes. All of those are guided by the crystal structure. Molecular interpretations of the AFM features of P2VB and DSP are given. (C) 1999 American Vacuum Society. [S0734-211X(99)03606-9]

J. Vac. Sci. Technol. B

The gas-solid chemical reactions of pure crystalline alcohol, such as triphenyl carbinol (1) and 1,1-dipbenylethanol-1 (3), with HCl gas and their mechanism are studied using atomic force microscopy (AFM) and known crystal packing data. AFM reveals that the main crystal face (001) of 1 exhibits volcanoes, whereas the long side face (100) gives volcanoes and craters in turn. Both (010) and (100) of 3 exhibit islands. All of those are guided by the crystal structure. Molecular interpretations of the AFM features are given. (C) 2000 American Vacuum Society.The gas-solid chemical reactions of pure crystalline alcohol, such as triphenyl carbinol (1) and 1,1-dipbenylethanol-1 (3), with HCl gas and their mechanism are studied using atomic force microscopy (AFM) and known crystal packing data. AFM reveals that the main crystal face (001) of 1 exhibits volcanoes, whereas the long side face (100) gives volcanoes and craters in turn. Both (010) and (100) of 3 exhibit islands. All of those are guided by the crystal structure. Molecular interpretations of the AFM features are given. (C) 2000 American Vacuum Society

Intraocular pressure and ocular shape changes during altitude acclimatization from Beijing to Lhasa

Purpose&nbsp;:&nbsp;To investigate changes of intraocular pressure (IOP) and ocular shape on ascent to high altitude from Beijing to Lhasa Methods&nbsp;:&nbsp;20 volunteers (17 men, 3 women) who were sent to work from Beijing to Lhasa, Tibet were enrolled. IOP, axial length (AL) and corneal curvature (K) were measured for twice at Beijing (altitude 43m) and Lhasa (altitude 3658m) respectively. They had the first examination at least 1 day before arriving Lhasa and had the second examination when stayed at Lhasa for 7 days or later. IOP was measured with applanation tonometer and the two tonometers have a consistency correction at Beijing before the study. AL was measured with two different type ultrasonic pachymeters and K was measured using two same type autofractometers. The data of highland and lowland were analyzed by paired-sample T test. Results&nbsp;:&nbsp;The mean values for IOP of Beijing was 12.75&plusmn;2.41 mmHg and Lhasa was 15.08&plusmn;3.35 mmHg. The mean AL was 24.83&plusmn;1.54 mm at Beijing and was 25.24&plusmn;1.38 mm at Lhasa. The IOP and AL increased significantly at the altitude of Lhasa (P&lt;0.05). The mean K was 43.54&plusmn;2.17 D at Beijing and 43.52&plusmn;2.21 D at Lhasa. Difference of K were not significant (P&gt;0.05).</p