Chemical Effects on Kβ/Kα X-Ray Intensity Ratio for 97mTc and 95mTc

開始ページ、終了ページ: 冊子体のページ付

Toxicogenomic Biomarkers for Liver Toxicity

Toxicogenomics (TGx) is a widely used technique in the preclinical stage of drug development to investigate the molecular mechanisms of toxicity. A number of candidate TGx biomarkers have now been identified and are utilized for both assessing and predicting toxicities. Further accumulation of novel TGx biomarkers will lead to more efficient, appropriate and cost effective drug risk assessment, reinforcing the paradigm of the conventional toxicology system with a more profound understanding of the molecular mechanisms of drug-induced toxicity. In this paper, we overview some practical strategies as well as obstacles for identifying and utilizing TGx biomarkers based on microarray analysis. Since clinical hepatotoxicity is one of the major causes of drug development attrition, the liver has been the best documented target organ for TGx studies to date, and we therefore focused on information from liver TGx studies. In this review, we summarize the current resources in the literature in regard to TGx studies of the liver, from which toxicologists could extract potential TGx biomarker gene sets for better hepatotoxicity risk assessment

Plasma physics and control studies planned in JT-60SA for ITER and DEMO operations and risk mitigation

| openaire: EC/H2020/633053/EU//EUROfusionA large superconducting machine, JT-60SA has been constructed to provide major contributions to the ITER program and DEMO design. For the success of the ITER project and fusion reactor, understanding and development of plasma controllability in ITER and DEMO relevant higher beta regimes are essential. JT-60SA has focused the program on the plasma controllability for scenario development and risk mitigation in ITER as well as on investigating DEMO relevant regimes. This paper summarizes the high research priorities and strategy for the JT-60SA project. Recent works on simulation studies to prepare the plasma physics and control experiments are presented, such as plasma breakdown and equilibrium controls, hybrid and steady-state scenario development, and risk mitigation techniques. Contributions of JT-60SA to ITER and DEMO have been clarified through those studies.Peer reviewe

<Poster Session>Snow Crab Behaviors in the Deep-sea Floor Revealed by VPS

19–22 May 2022 Kyoto, JapanThe catch of snow crab in the Sea of Japan has decreased. Therefore, there are many regulations including the size limitation and protected season, protected areas and production of fingerlings to enhance the resources. However, these measures may be insufficient to maintain and restore resources because the effect of the regulation was not evaluated very well. It is very difficult to observe the snow crab behaviors because they inhabited the deep-sea floor in the Sea of Japan. Therefor we began to investigate the challenging biotelemetry study in order to reveal their behaviors. In this paper, we introduced preliminary results of the deep-sea trials of Vemco positioning system (VPS). This was our first experience using the deep-sea VPS study