Lanthanum Deposition in the Stomach: Usefulness of Scanning Electron Microscopy for Its Detection

After having been treated with lanthanum carbonate administration for 4 years for hyperphosphatemia, a 75-year-old Japanese woman undergoing hemodialysis was diagnosed with lanthanum phosphate deposition in the stomach. The deposition, seen as white microgranules, was observed using esophagogastroduodenoscopy with magnifying observation. To the best of our knowledge, these are the minutest endoscopy images of lanthanum phosphate deposition in the gastric mucosa. Scanning electron microscopy (SEM) observation enabled easier identification of the deposited material, which was visible as bright areas. The present case suggests the usefulness of SEM observation in the detection of lanthanum phosphate deposition in the gastrointestinal tract

Antimicrobial activity of synthetic bornyl benzoates against Trypanosoma cruzi.

We report here for the first time the in vitro effects of (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-yl- 39,49,59-trimethoxy benzoate (1) and (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-yl benzoate (2) on the growth and ultrastructure of Trypanosoma cruzi. These two synthetic compounds exerted an antiproliferative effect on the epimastigote forms of the parasite. The ICs50/72h of two synthetic L-bornyl benzoates, 1 and 2, was 10.1 and 12.8 mg/ml, respectively. Both compounds were more selective against epimastigotes than HEp-2 cells. Ultrastructural analysis revealed intense cytoplasmic vacuolization and the appearance of cytoplasmic materials surrounded by membranes. The treatment of peritoneal macrophages with compounds 1 and 2 caused a significant decrease in the number of T. cruzi-infected cells. L-Bornyl benzoate derivatives may serve as a potential source for the development of more effective and safer chemotherapeutic agents against T. cruzi infections

Acral Persistent Papular Mucinosisの1例

雑誌掲載版49歳女.約5年前から両手背に自覚症状のない丘疹が多発し放置していたところ,皮疹が改善しなかった.初診時,両手背に直径2mm大迄の正常皮膚色からやや黄色調の境界不明瞭な充実性の丘疹が集簇・散在していた.左手背部の病理組織学的所見では丘疹は真皮上層の浮腫,膠原線維間の開大,走行の乱れ,断裂があり,膠原線維間に好塩基性の沈着物が認められた.この沈着物はアルシアンブルー染色で陽性を示し,トルイジンブルー染色で異染性を示し,睾丸ヒアルロニダーゼ消化試験結果からヒアルロン酸が主体と考えられた.甲状腺機能異常やM蛋白血症等の合併症は認められず,以上の所見から本症例は典型的なacral persistent popular mucinosis(皮膚ムチン沈着症)と診断された.副腎皮質ステロイド軟膏の塗布による加療が行われたが,皮疹の改善は認められず2年を経過した現在,著変を認めていな

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