Training cessation and subsequent retraining of a world-class female Olympic sailor after Tokyo 2020: A case study

Olympic sailing is a complex sport where sailors are required to predict and interpret weather conditions while facing high physical and physiological demands. While it is essential for sailors to develop physical and physiological capabilities toward major competition, monitoring training status following the competition is equally important to minimize the magnitude of detraining and facilitate retraining. Despite its long history in the modern Olympics, reports on world-class sailors' training status and performance characteristics across different periodization phases are currently lacking. This case study aimed to determine the influence of training cessation and subsequent retraining on performance parameters in a world-class female sailor. A 31-year old female sailor, seventh in the Women's Sailing 470 medal race in Tokyo 2020, completely stopped training for 4 weeks following the Olympics, and resumed low-intensity training for 3 weeks. Over these 7 weeks, 12.7 and 5.3% reductions were observed in 6 s peak cycling power output and jump height, respectively, with a 4.7% decrease in maximal aerobic power output. Seven weeks of training cessation-retraining period induced clear reductions in explosive power production capacities but less prominent decreases in aerobic capacity. The current findings are likely attributed to the sailor's training characteristics during the retraining period.This study was part of Functional Development Project for Resilient Athlete Support commissioned by Japan Sports Agency

Coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer

INTRODUCTION: Many laboratories are currently evaluating the usefulness of determination of HER2, p53, and Ki67 proliferation indices using immunohistochemical techniques in cancer. Although the available studies suggest that these factors might indeed be helpful in making treatment decisions in cancer patients, their clinical usefulness is still controversial. METHODS: Expression of HER2, p53, and Ki67 was examined by immunohistochemistry in samples of breast tissue from 506 patients with invasive ductal carcinoma, obtained between 1981 and 1999 (median follow up period 82 months), and their significance for prognosis was analyzed. RESULTS: Of the 506 carcinoma tissue samples, 20.1%, 29.0%, and 53.6% were positive for HER2 over-expression, p53 protein accumulation, and Ki67 expression, respectively. Over-expression of HER2 significantly reduced disease free (P = 0.02) and overall survival (P = 0.005). Accumulation of p53 protein significantly decreased disease free (P = 0.01) and overall survival (P = 0.01). Patients with tumors that were positive for both HER2 and p53 relapsed and died within a significantly shorter period of time after surgery (P = 0.0001 and P < 0.0001, respectively). In multivariate analysis, patients with both HER2 and p53 positive tumors had considerably decreased overall survival (P = 0.04), as did patients with larger tumor size and positive lymph node status. CONCLUSION: The findings of the present study indicate that the coexistence of HER2 over-expression and p53 protein accumulation is a strong prognostic molecular marker in breast cancer

Challenges to Establishing Partnerships in Peer Support Activities for Individuals with Mental Disorders

This study aimed to clarify the current state of and issues related to establishing partnerships in peer support activities for individuals with mental disorders. An anonymous, self-administered questionnaire survey was conducted among participants of a meeting for peer supporters of individuals with mental disorders. The following aspects were assessed: participant characteristics, motivations and difficulties of engaging in such services, and various other challenges. Free response content in the questionnaire was analyzed with qualitative and inductive methods. Our findings highlight the need to create an appropriate environment for peer supporters to share their recovery experiences in order to assist the formation of relationships with individuals with mental disorders through peer support services

Multiplicity of Nova Envelope Solutions and Occurrence of Optically Thick Winds

We revisit the occurrence condition of optically thick winds reported by Kato (1985) and Kato and Hachisu (1989) who examined mathematically nova envelope solutions with an old opacity and found that optically thick winds are accelerated only in massive white dwarfs (WDs) of >~ 0.9 Mo. With the OPAL opacity we find that the optically thick wind occurs for >~ 0.6 Mo WDs and that the occurrence of winds depends not only on the WD mass but also on the ignition mass. When the ignition mass is larger than a critical value, winds are suppressed by a density-inversion layer. Such a static solution can be realized in WDs of mass ~0.6-0.7 Mo. We propose that sequences consisting only of static solutions correspond to slow evolutions in symbiotic novae like PU Vul because PU Vul shows no indication of strong winds in a long-lasted flat peak followed by a very slow decline in its light curve.Comment: 8 pages including 11 figures, to appear in Ap

Circulatory C-type natriuretic peptide reduces mucopolysaccharidosis-associated craniofacial hypoplasia in vivo

Skeletal alterations in the head and neck region, such as midfacial hypoplasia, foramen magnum stenosis and spinal canal stenosis, are commonly observed in patients with mucopolysaccharidosis (MPS). However, enzyme replacement therapy (ERT), one of the major treatment approaches for MPS, shows limited efficacy for skeletal conditions. In this study, we analysed the craniofacial morphology of mice with MPS type VII, and investigated the underlying mechanisms promoting jaw deformities in these animals. Furthermore, we investigated the effects of C-type natriuretic peptide (CNP), a potent endochondral ossification promoter, on growth impairment of the craniofacial region in MPS VII mice when administered alone or in combination with ERT. MPS VII mice exhibited midfacial hypoplasia caused by impaired endochondral ossification, and histological analysis revealed increased number of swelling cells in the resting zone of the spheno-occipital synchondrosis (SOS), an important growth centre for craniomaxillofacial skeletogenesis. We crossed MPS VII mice with transgenic mice in which CNP was expressed in the liver under the control of the human serum amyloid-P component promoter, resulting in elevated levels of circulatory CNP. The maxillofacial morphological abnormalities associated with MPS VII were ameliorated by CNP expression, and further prevented by a combination of CNP and ERT. Histological analysis showed that ERT decreased the swelling cell number, and CNP treatment increased the width of the proliferative and hypertrophic zones of the SOS. Furthermore, the foramen magnum and spinal stenoses observed in MPS VII mice were significantly alleviated by CNP and ERT combination. These results demonstrate the therapeutic potential of CNP, which can be used to enhance ERT outcome for MPS VII-associated head and neck abnormalities

Deep microbial proliferation at the basalt interface in 33.5–104 million-year-old oceanic crust

The upper oceanic crust is mainly composed of basaltic lava that constitutes one of the largest habitable zones on Earth. However, the nature of deep microbial life in oceanic crust remains poorly understood, especially where old cold basaltic rock interacts with seawater beneath sediment. Here we show that microbial cells are densely concentrated in Fe-rich smectite on fracture surfaces and veins in 33.5- and 104-million-year-old (Ma) subseafloor basaltic rock. The Fe-rich smectite is locally enriched in organic carbon. Nanoscale solid characterizations reveal the organic carbon to be microbial cells within the Fe-rich smectite, with cell densities locally exceeding 1010 cells/cm3. Dominance of heterotrophic bacteria indicated by analyses of DNA sequences and lipids supports the importance of organic matter as carbon and energy sources in subseafloor basalt. Given the prominence of basaltic lava on Earth and Mars, microbial life could be habitable where subsurface basaltic rocks interact with liquid water

A Wide and Deep Exploration of Radio Galaxies with Subaru HSC (WERGS). VI. Distant Filamentary Structures Pointed Out by High- z Radio Galaxies at z ∼4

We present the environmental properties around high-$z$ radio galaxies (HzRGs) at $z\sim4$, which have been poorly investigated because of their rarity. We use the largest samples of HzRGs and $g$-dropout galaxy overdense regions at $z\sim4$, which were constructed from Hyper Suprime-Cam Subaru Strategic Program, to characterize the HzRG environments statistically. We measure the $g$-dropout galaxy overdensities around 21 HzRGs whose rest-frame 1.4 GHz radio luminosities ($L_{1.4\mathrm{GHz}}$) are $10^{26-27}$ W Hz$^{-1}$. We find that the overdensities around the faint HzRGs with $L_{1.4\mathrm{GHz}}\sim10^{26.0-26.5}$ W Hz$^{-1}$ tend to be higher than that of the $g$-dropout galaxies. On the other hand, no significant difference of density environments is found between the luminous HzRGs with $L_{1.4\mathrm{GHz}}\sim10^{26.5-27.0}$ W Hz$^{-1}$ and the $g$-dropout galaxies. The HzRGs are found to occupy more massive halos than $g$-dropout galaxies through a cross-correlation between the HzRGs and $g$-dropout galaxies. This trend is more pronounced in the faint HzRGs. These results are consistent with a scenario where HzRGs get older and more massive as the radio-luminosity decreases. The HzRGs are expected to trace the progenitors of local cluster halos from their calculated halo mass. In addition, we find that surrounding galaxies tend to distribute along the radio-jet major axis of the HzRGs at angular distances less than $\lesssim500$ physical kpc. Our findings imply the onset of the filamentary structures around the HzRGs at $z\sim4$.Comment: 22 pages, 8 figures, accepted in Ap

A Wide and Deep Exploration of Radio Galaxies with Subaru HSC (WERGS). IX. The most overdense region at z ∼ 5 inhabited by a massive radio galaxy

We report on the galaxy density environment around a high-z radio galaxy (HzRG) at z = 4.72, HSC J083913.17+011308.1 (HSC J0839+0113), probed using an r-dropout Lyman break galaxy (LBG) sample from the Hyper Suprime-Cam Subaru Strategic Program data. We find that HSC J0839+0113 resides in the outskirts of an overdense region identified by the r-dropout galaxies at a 4.7σ significance level. The projected distance between HSC J0839+0113 and the peak position of the overdense region is 0.4 physical Mpc, which is shorter than the typical protocluster radius in this epoch. According to the extended Press–Schechter and the light cone models, the HSC J0839+0113-hosted overdense region is expected to evolve into a halo &gt;1014 M⊙ at z = 0 with a high probability of &gt;80%⁠. These findings suggest that HSC J0839+0113 is associated with a protocluster. The HSC J0839+0113 rich-system is the most overdense region of LBGs among the known protoclusters with LBGs in the same cosmic epoch

N-Acetyl-d-Glucosamine-Binding Lectin in Acropora tenuis Attracts Specific Symbiodiniaceae Cell Culture Strains

Many corals establish symbiosis with Symbiodiniaceae cells from surrounding environments, but very few Symbiodiniaceae cells exist in the water column. Given that the N-acetyl-d-glucosamine-binding lectin ActL attracts Symbiodiniaceae cells, we hypothesized that corals must attract Symbiodiniaceae cells using ActL to acquire them. Anti-ActL antibody inhibited acquisition of Symbiodiniaceae cells, and rearing seawater for juvenile Acropora tenuis contained ActL, suggesting that juvenile A. tenuis discharge ActL to attract these cells. Among eight Symbiodiniaceae cultured strains, ActL attracted NBRC102920 (Symbiodinium tridacnidorum) most strongly followed by CS-161 (Symbiodinium tridacnidorum), CCMP2556 (Durusdinium trenchii), and CCMP1633 (Breviolum sp.); however, it did not attract GTP-A6-Sy (Symbiodinium natans), CCMP421 (Effrenium voratum), FKM0207 (Fugacium sp.), and CS-156 (Fugacium sp.). Juvenile polyps of A. tenuis acquired limited Symbiodiniaceae cell strains, and the number of acquired Symbiodiniaceae cells in a polyp also differed from each other. The number of Symbiodiniaceae cells acquired by juvenile polyps of A. tenuis was correlated with the ActL chemotactic activity. Thus, ActL could be used to attract select Symbiodiniaceae cells and help Symbiodiniaceae cell acquisition in juvenile polyps of A. tenuis, facilitating establishment of symbiosis between A. tenuis and Symbiodiniaceae cells