Lymphoma caused by intestinal microbiota.

The intestinal microbiota and gut immune system must constantly communicate to maintain a balance between tolerance and activation: on the one hand, our immune system should protect us from pathogenic microbes and on the other hand, most of the millions of microbes in and on our body are innocuous symbionts and some can even be beneficial. Since there is such a close interaction between the immune system and the intestinal microbiota, it is not surprising that some lymphomas such as mucosal-associated lymphoid tissue (MALT) lymphoma have been shown to be caused by the presence of certain bacteria. Animal models played an important role in establishing causation and mechanism of bacteria-induced MALT lymphoma. In this review we discuss different ways that animal models have been applied to establish a link between the gut microbiota and lymphoma and how animal models have helped to elucidate mechanisms of microbiota-induced lymphoma. While there are not a plethora of studies demonstrating a connection between microbiota and lymphoma development, we believe that animal models are a system which can be exploited in the future to enhance our understanding of causation and improve prognosis and treatment of lymphoma

Direct numerical simulation of dispersed particles in a compressible fluid

We present a direct numerical simulation method for investigating the dynamics of dispersed particles in a compressible solvent fluid. The validity of the simulation is examined by calculating the velocity relaxation of an impulsively forced spherical particle with a known analytical solution. The simulation also gives information about the fluid motion, which provides some insight into the particle motion. Fluctuations are also introduced by random stress, and the validity of this case is examined by comparing the calculation results with the fluctuation-dissipation theorem.Comment: 7 pages, 5 figure

Electronic Transport in Fullerene C20 Bridge Assisted by Molecular Vibrations

The effect of molecular vibrations on electronic transport is investigated with the smallest fullerene C20 bridge, utilizing the Keldysh nonequilibrium Green's function techniques combined with the tight-binding molecular-dynamics method. Large discontinuous steps appear in the differential conductance when the applied bias-voltage matches particular vibrational energies. The magnitude of the step is found to vary considerably with the vibrational mode and to depend on the local electronic states besides the strength of electron-vibration coupling. On the basis of this finding, a novel way to control the molecular motion by adjusting the gate voltage is proposed.Comment: 9 pages, 4 figures, accepted for publication in Phys. Rev. Let

Critical velocity of flowing supersolids of dipolar Bose gases in optical lattices

We study superfluidity of supersolid phases of dipolar Bose gases in two-dimensional optical lattices. We perform linear stability analyses for the corresponding dipolar Bose-Hubbard model in the hardcore boson limit to show that a supersolid can have stable superflow until the flow velocity reaches a certain critical value. The critical velocity for the supersolid is found to be significantly smaller than that for a conventional superfluid phase. We propose that the critical velocity can be used as a signature to identify the superfluidity of the supersolid phase in experiment.Comment: 7 pages, 4 figures, published versio

A Coherent Ising Machine Based On Degenerate Optical Parametric Oscillators

A degenerate optical parametric oscillator network is proposed to solve the NP-hard problem of finding a ground state of the Ising model. The underlying operating mechanism originates from the bistable output phase of each oscillator and the inherent preference of the network in selecting oscillation modes with the minimum photon decay rate. Computational experiments are performed on all instances reducible to the NP-hard MAX-CUT problems on cubic graphs of order up to 20. The numerical results reasonably suggest the effectiveness of the proposed network.Comment: 18 pages, 6 figure

Network of Time-Multiplexed Optical Parametric Oscillators as a Coherent Ising Machine

Finding the ground states of the Ising Hamiltonian [1] maps to various combinatorial optimization problems in biology, medicine, wireless communications, artificial intelligence, and social network. So far no efficient classical and quantum algorithm is known for these problems, and intensive research is focused on creating physical systems - Ising machines - capable of finding the absolute or approximate ground states of the Ising Hamiltonian [2-6]. Here we report a novel Ising machine using a network of degenerate optical parametric oscillators (OPOs). Spins are represented with above-threshold binary phases of the OPOs and the Ising couplings are realized by mutual injections [7]. The network is implemented in a single OPO ring cavity with multiple trains of femtosecond pulses and configurable mutual couplings, and operates at room temperature. We programed the smallest non-deterministic polynomial time (NP)- hard Ising problem on the machine, and in 1000 runs of the machine no computational error was detected

A Molecular Hydrodynamic Theory of Supercooled Liquids and Colloidal Suspensions under Shear

We extend the conventional mode-coupling theory of supercooled liquids to systems under stationary shear flow. Starting from generalized fluctuating hydrodynamics, a nonlinear equation for the intermediate scattering function is constructed. We evaluate the solution numerically for a model of a two dimensional colloidal suspension and find that the structural relaxation time decreases as $\dot{\gamma}^{-\nu}$ with an exponent $\nu \leq 1$, where $\dot{\gamma}$ is the shear rate. The results are in qualitative agreement with recent molecular dynamics simulations. We discuss the physical implications of the results.Comment: 5 pages, 1 figur