The impact of innovations in the production of biologically valuable food products on supply chain management in the regional economy

Abstract— The article shows a study of the role of supply chain management of innovative biologically valuable food products in the industrial development and economy of the region. The analysis of the process of updating the assortment of food products based on the introduction of innovative developments and production principles conducive to the release of a healthy diet product (innovative product) is presented. The main provisions of the concept of healthy food products, the category of “innovative food products” are analyzed. The article systematizes the definitions of the concept of “innovative product”. Based on the results of the study, features, functional properties and characteristic features of an innovative food product are determined. Based on the concept of “innovative food product”, the concepts of “new food product”, “improved food product”, and “modified food product” are formulated. A classification model of innovative food products is presented. Based on it, it is shown that the development, production and sale of an innovative food product two functions: economic and social. The study made it possible to formulate the main criteria that make it possible to attribute a food product to a group of innovative food products. The article describes the characteristics of an innovative food product, describes market and consumer properties. The author's definitions of concepts are given: “innovative food product”, “new food product”, “improved food product”, “modified food product”. A classification of innovative food products is proposed

Морфологические аспекты повреждений проксимального отдела плечевой кости у разных возрастных групп

Introduction. Fracture of the proximal humerus is a common injury that accounts for up to 12 % of all bone fractures and up to 65 % of humeral fractures. 13 % to 16 % of fractures in this segment are multi-fragment with bone impression. This significantly complicates the task of internal fixation. This study aims to analyze the gender and age group distribution of patients with proximal humerus fractures, and morphological aspects of these injuries.Materials and methods. This paper presents a retrospective analysis of the epidemiological and morphological parameters of patients treated surgically for proximal humerus injuries at the Department of Traumatology and Orthopedics of the State Regional Clinical Hospital of the Republic of Bashkortostan № 1 in the city of Oktyabrsky in 2010–2016. The total of 191 patients were included in the study, 121 (63.35 %) females and 70 (36.65 %) males.Results and discussions. A signifi cant increase (more than three times) in the number of proximal humerus fractures was recorded in women in the 50–65 age group and in men in the 55–60 age group. The increase in the incidence of this type of injury does not exceed 22.4 % in comparison to the younger age groups. The increase in the number of injuries in question is undoubtedly due to changes in the bone metabolism in women. The analysis of character and morphology of fractures in women of older age groups indicates a greater prevalence of unstable injury of type 1.1.B and 1.1.C according to AO/ASIF classifi cation, which, again, is due to the demineralization of the segment determined by systemic metabolic abnormalities. The fi ndings indicate the need for perioperative monitoring of the bone metabolism parameters.Conclusion.The morphology and types of fractures depend on a patient’s age and bone quality. A signifi cant increase in this pathology in women of perimenopausal age refl ects changes in bone metabolism.Введение. Переломы проксимальной части плечевой кости — это травма, которая составляет до 12 % от числа всех переломов костей скелета и до 65 % от переломов плечевой кости. От 13 до 16 % переломов в данном сегменте имеют многооскольчатый характер с импрессией костной ткани, что значительно усложняет задачу внутренней фиксации. Цель данного исследования — проанализировать гендерную и возрастную структуру пациентов с переломами проксимального отдела плечевой кости, а также морфологические особенности данных повреждений.Материалы и методы. Проведен ретроспективный анализ эпидемиологических и морфологических параметров пациентов, прооперированных по поводу повреждений проксимального отдела плечевой кости на базе отделения травматологии и ортопедии ГБУЗ РБ ГБ № 1 г. Октябрьский за период с ноября 2010 по ноябрь 2016 г.Результаты и обсуждение. Значительное увеличение количества переломов проксимального отдела плечевой кости (более чем в 3 раза) регистрируется у женщин в возрастной группе 50–65 лет, у мужчин в возрастной категории 55–60 лет. Увеличение количества повреждений у женщин, несомненно, обусловлено перименопаузальными изменениями костного метаболизма. Анализ характера и морфологических особенностей переломов у женщин старших возрастных групп свидетельствует о большей распространенности нестабильных повреждений типа 1.1.В и 1.1.С по классификации АО/ASIF, что опять-таки обусловлено деминерализацией сегмента на фоне сопутствующих обменно-метаболических нарушений системного характера. Выявленные особенности свидетельствуют о необходимости периоперационного мониторинга параметров костного метаболизма.Заключение. Морфология и типы переломов зависят от возраста пациента и качества кости. Значительный рост данной патологии у женщин перименопаузального возраста говорит об изменениях метаболизма в костях, вследствие чего необходим мониторинг костного метаболизма в периоперационный период

Prevalence and associated factors of anemia in a Russian population: the Ural eye and medical study

Background: Although anemia is one of the leading causes of the global burden of disease, information about its prevalence in Russia is mostly missing. We therefore assessed its prevalence and associated factors in a Russian population. Methods: The population-based Ural Eye and Medical Study included 5899 (80.5%) out of 7328 eligible individuals (mean age:59.0 ± 10.7 years;range:40–94 years) who underwent a standardized interview and detailed general examination. The definition of anemia was based on the hemoglobin concentration (definition #1:hemoglobin concentration < 140 g/L in men,< 130 g/L in women; definition #2:hemoglobin concentration < 130 g/L in men,< 120 g/L in women [World Health Organization definition]). Results: Higher hemoglobin concentration (mean:142.6 ± 14.8 g/L; range:80-171 g/L) was associated (multivariable analysis) with male gender (P < 0.001; standardized regression coefficient beta:-0.20), higher waist-hip circumference ratio (P < 0.001;beta:0.05), higher prevalence of car ownership (P < 0.001;beta:0.05), higher blood concentrations of bilirubin (P < 0.001;beta:0.05) and triglycerides (P < 0.001;beta:0.06), lower erythrocyte sedimentation rate (P < 0.001;beta:-0.32), and shorter blood clotting time (P < 0.001;beta:-0.39). Using definition #1 and #2, anemia was detected in 1385 individuals (23.6%;95% confidence interval CI)CI:22.5,24.7) and in 453 individuals (7.7%;95%CI:7.0,8.4), respectively. Prevalence of moderate anemia (hemoglobin concenttration:110 g/L-80 g/L), detected in 165 individuals (2.8%;95%CI:2.4,3.2), increased with younger age (P = 0.008;odds ratio (OR):0.98;95%CI:0.96,0.99), female gender (P < 0.001;OR:2.52;95%CI:1.47,4.33), higher erythrocyte sedimentation rate (P < 0.001;OR:1.08;95%CI:1.06,1.09), longer blood clotting time (P < 0.001;OR:8.56;95%CI:5.68,12.9), and marginally significantly, with a lower waist-hip circumference ratio (P = 0.058;OR:0.13;95%CI:0.02,1.07). In women, it was significantly (P < 0.001) higher before menopause (8.8%;95%CI:6.4,11.1) than after menopause (3.5%;95%CI:2.8,4.3). Conclusions: In this Russian population as compared to populations from countries with a similar socio-demographic index, anemia prevalence was relatively low. As in other populations, higher anemia prevalence was strongly and inversely associated with menopause, and to a minor degree, with lower waist-hip circumference ratio and lower socio-economic background

Factors affecting the results of analgesic therapy. Results of the Russian multicentre study of NOTE (NSAID: Open-label Trial of Efficacy)

Non-steroidal anti-inflammatory drugs (NSAIDs) are most popular medications for the treatment of pain in common musculoskeletal diseases such as osteoarthritis (OA) and non-specific low back pain (LBP). However, the factors affecting the effectiveness of these drugs have not been determined fully. Aim: to identify factors affecting the effectiveness of NSAIDs in patients with OA and LBP. Materials and methods. An observational study was conducted to evaluate the effectiveness of a 2-week course of NSAIDs in OA and LBP in real clinical practice. The study group consisted of 3604 patients with OA and LBP (60.6% women and 39.4% men, mean age 55.0±13.4 years). According to the study design, aceclofenac (Airtal) and other NSAIDs used in the ratio 1:1. The main criterion of effectiveness was the frequency of complete pain relief after 2 weeks of therapy. In addition, the decrease of pain and general health were determined on a 10-point numerical rating scale (NRS). We compared the frequency of complete pain relief in patients who had and did not have the studied factors. The value of the studied factors was determined using OR (95% CI). Results and discussion. Most patients received aceclofenac (54.9%), as well as diclofenac (2.0%), ketoprofen (1.9%), lornoxicam (2.2%), meloxicam (13.7%), naproxen (2.1%), nimesulide (5.8%), celecoxib (5.9%), ethicoxib (7.1%) and other NSAIDs (4.4%); 56.2% of patients received muscle relaxants, mainly tolperisone (74.7%), vitamin B (10.4%), and proton pump inhibitors (42.8%). Complete pain relief was achieved in 54.8% of patients. The pain decrease and general health improvement were (for NRS) 63.9±13.4% and 61.7±14.8%, respectively. The efficacy of aceclofenac was slightly higher than in the whole group: complete pain relief was in 59.9% of patients. Adverse events in aceclofenac use were observed in 2.3% of patients, other NSAIDs-from 2.4 to 14.1%. The frequency of complete pain relief was higher in men: OR 1,239 (95% CI 1.08-1.418; p=0.002), who had the first episode of pain - OR 3.341 (95% CI 2.873-3.875; p=0.000), a good" response " to NSAIDs in history - OR 1.656 (95% CI 1.385-1.980; p=0.000) and received NSAIDs in combination with muscle relaxants - OR 1.218 (95% CI 1.067-1.390; p=0.004). The effect of therapy is lower in patients 65 years and older-OR 0,378 (95% CI 0.324-0.442; p=0,000), with body mass index >30 kg/m² - OR 0.619 (95% CI 0.529-0.723; p=0.000), with severe pain (≥7 points NRS) - OR 0.662 (95% CI 0.580-0.756; p=0.002), with pain at rest, - OR 0.515 (95% CI 0.450-0,589; p=0.000), pain at night - OR 0.581 (95% CI 0.501-0.672; p=0.000) and the presence of stiffness - OR 0.501 (95% CI 0.438-0,573; p=0.000). Treatment results are significantly worse in the cases of combination of LBP and joint pain, as well as pain in the trochanter major and pes anserinus area (

Allergy-Clinical characteristics of children with asthma in the Republic of Bashkortostan

The characteristic of allergy-clinical status of children with bronchial asthma. A clinical, functional, immunological, allergy screening, evaluating the degree of asthma control. Noted the possible impact of smoking on lung function of respondents. Correlation between the values of AST-test, the level of bronchial lability and speed performance of the airway.Дана характеристика клинико-аллергологического статуса детей с бронхиальной астмой. Проведено клиническое, функциональное, иммунологическое, аллергологическое обследование, дана оценка степени контроля над бронхиальной астмой. Отмечено возможное влияние курения на показатели функции внешнего дыхания респондентов. Выявлены корреляционные связи между значениями АСТ-теста, уровнем бронхиальной лабильности и скоростными показателями проходимости дыхательных путей

Возможности фармакологического лечения остеоартрита: фокус на симптоматические медленно действующие препараты (SYSADOA) и индивидуальные особенности пациента. Резолюция международного совещания экспертов

The paper presents the results of the Osteoarthritis (OA) Expert Council held on September 8, 2019, which was attended by Russian and foreign specialists. The experts considered pharmacological treatment options for OA. The expert meeting resolution states that the treatment of patients with OA should be based on an individual assessment of the patient and on a modern evidence base of therapy efficacy.Treatment of patients with OA is based on the principles of evidence-based medicine that requires an integrated approach and the need of SYSADOAs prescription. Combined drugs with therapeutic dosages of chondroitin sulfate and glucosamine in the early stages of the disease are available as basic agents. The place of paracetamol in the anesthetic therapy algorithm in OA needs to be clarified. It is also noted that when choosing nonsteroidal anti-inflammatory drugs for OA treatment, it is important to take into account individual patient characteristics and the presence of comorbidities.Представлены результаты Экспертного совета по остеоартриту (ОА), проходившего 8 сентября 2019 г., в котором приняли участие российские и зарубежные специалисты. Рассматривались возможности фармакологического лечения ОА. В резолюции совещания указано, что лечение больных ОА должно быть основано на индивидуальной оценке состояния пациента и современных доказательствах эффективности терапии. Лечение больных ОА на основании принципов доказательной медицины предполагает комплексный подход и назначение SYSADOA. Комбинированные препараты с терапевтическими дозами хондроитина сульфата и глюкозамина уже на ранних стадиях заболевания рассматриваются в качестве базисных средств. Место парацетамола в алгоритме обезболивающей терапии при ОА требует уточнения. Отмечено также, что при выборе нестероидных противовоспалительных препаратов для лечения ОА важно учитывать индивидуальные особенности пациента и наличие коморбидных состояний

The comparative responsiveness of Hospital Universitario Princesa Index and other composite indices for assessing rheumatoid arthritis activity

Objective To evaluate the responsiveness in terms of correlation of the Hospital Universitario La Princesa Index (HUPI) comparatively to the traditional composite indices used to assess disease activity in rheumatoid arthritis (RA), and to compare the performance of HUPI-based response criteria with that of the EULAR response criteria. Methods Secondary data analysis from the following studies: ACT-RAY (clinical trial), PROAR (early RA cohort) and EMECAR (pre-biologic era long term RA cohort). Responsiveness was evaluated by: 1) comparing change from baseline (Delta) of HUPI with Delta in other scores by calculating correlation coefficients; 2) calculating standardised effect sizes. The accuracy of response by HUPI and by EULAR criteria was analyzed using linear regressions in which the dependent variable was change in global assessment by physician (Delta GDA-Phy). Results Delta HUPI correlation with change in all other indices ranged from 0.387 to 0.791); HUPI's standardized effect size was larger than those from the other indices in each database used. In ACT-RAY, depending on visit, between 65 and 80% of patients were equally classified by HUPI and EULAR response criteria. However, HUPI criteria were slightly more stringent, with higher percentage of patients classified as non-responder, especially at early visits. HUPI response criteria showed a slightly higher accuracy than EULAR response criteria when using Delta GDA-Phy as gold standard. Conclusion HUPI shows good responsiveness in terms of correlation in each studied scenario (clinical trial, early RA cohort, and established RA cohort). Response criteria by HUPI seem more stringent than EULAR''s

Features of the Supply Chain Development in the Areas of Oil Production and Refining

Abstract— The oil industry is one of the most important industries, which are the main export goods of Russia. The oil and gas industry is involved in a global supply-chain that includes domestic and international transportation, ordering and inventory visibility and control, materials handling, import/export facilitation and information technology. In addition, the price of the third main component of exports of natural gas substantially depends on the level of prices for oil and oil products. The oil industry of the Russian Federation is closely connected with all sectors of the national economy, and therefore is of great importance for the Russian economy. The demand for oil is always ahead of the offer, so almost all developed countries in the world are interested in the successful development of our oil industry. The object of the research of this article is to organize the supply chain management development in the areas of oil production and refining. The subject of research is the territorial organization of oil production and refining. The purpose of the work is to analyze the territorial organization of oil production and refining in Russia. The goal of the research involves the solution of the following main tasks: To study the theoretical and methodological issues of the oil industry; Identify geographic differences in the distribution of petroleum resources; to substantiate ways to improve the territorial organization of oil production and refining in Russia. The organization of the development of the supply chain management in the areas of oil production and refining is characterized by significant features. These include issues of investment policy and the development of innovations, the efficiency of managing production clusters, the tax structure in this sector of the economy, the supply chain foreign economic activity and others

Morphological Aspects of Proximal Humerus Fractures in Different Age Groups

Introduction. Fracture of the proximal humerus is a common injury that accounts for up to 12 % of all bone fractures and up to 65 % of humeral fractures. 13 % to 16 % of fractures in this segment are multi-fragment with bone impression. This significantly complicates the task of internal fixation. This study aims to analyze the gender and age group distribution of patients with proximal humerus fractures, and morphological aspects of these injuries.Materials and methods. This paper presents a retrospective analysis of the epidemiological and morphological parameters of patients treated surgically for proximal humerus injuries at the Department of Traumatology and Orthopedics of the State Regional Clinical Hospital of the Republic of Bashkortostan № 1 in the city of Oktyabrsky in 2010–2016. The total of 191 patients were included in the study, 121 (63.35 %) females and 70 (36.65 %) males.Results and discussions. A signifi cant increase (more than three times) in the number of proximal humerus fractures was recorded in women in the 50–65 age group and in men in the 55–60 age group. The increase in the incidence of this type of injury does not exceed 22.4 % in comparison to the younger age groups. The increase in the number of injuries in question is undoubtedly due to changes in the bone metabolism in women. The analysis of character and morphology of fractures in women of older age groups indicates a greater prevalence of unstable injury of type 1.1.B and 1.1.C according to AO/ASIF classifi cation, which, again, is due to the demineralization of the segment determined by systemic metabolic abnormalities. The fi ndings indicate the need for perioperative monitoring of the bone metabolism parameters.Conclusion.The morphology and types of fractures depend on a patient’s age and bone quality. A signifi cant increase in this pathology in women of perimenopausal age refl ects changes in bone metabolism