80 research outputs found
Political Rhetoric in China and in Imperial Rome: the Persuader, the Ruler, the Audience
The most fundamental difference between political rhetoric in traditional China and in the Greco-Roman worldβand specifically in Rome, with which I will deal hereβis, as is rightly stressed by some of the contributors to this splendid volume, that in China political rhetoric is invariably addressed by a βpersuaderβ to a single manβthe autocratic ruler, and not to the public or to collective civic bodies. In Romain Grazianiβs words, βThis canonical political pattern must be understood within t..
Electronic Properties of Functionalized Diamanes for Field-Emission Displays
Ultrathin diamond films, or diamanes, are promising quasi-2D materials that are
characterized by high stiffness, extreme wear resistance, high thermal conductivity, and chemical
stability. Surface functionalization of multilayer graphene with different stackings of layers could
be an interesting opportunity to induce proper electronic properties into diamanes. Combination
of these electronic properties together with extraordinary mechanical ones will lead to their
applications as field-emission displays substituting original devices with light-emitting diodes or
organic light-emitting diodes. In the present study, we focus on the electronic properties of
fluorinated and hydrogenated diamanes with (111), (110), (0001), (101Μ
0), and (2Μ
110)
crystallographic orientations of surfaces of various thicknesses by using first-principles calculations
and Bader analysis of electron density. We see that fluorine induces an occupied surface electronic
state, while hydrogen modifies the occupied bulk state and also induces unoccupied surface states.
Furthermore, a lower number of layers is necessary for hydrogenated diamanes to achieve the convergence of the work function in
comparison with fluorinated diamanes, with the exception of fluorinated (110) and (2Μ
110) films that achieve rapid convergence and
have the same behavior as other hydrogenated surfaces. This induces a modification of the work function with an increase of the
number of layers that makes hydrogenated (2Μ
110) diamanes the most suitable surface for field-emission displays, better than the
fluorinated counterparts. In addition, a quasi-quantitative descriptor of surface dipole moment based on the TantardiniβOganov
electronegativity scale is introduced as the average of bond dipole moments between the surface atoms. This new fundamental
descriptor is capable of predicting a priori the bond dipole moment and may be considered as a new useful feature for crystal
structure prediction based on artificial intelligence
Optoelectronic properties of a photosystem I - carbon nanotube hybrid system
The photoconductance properties of photosystem I (PSI) covalently bound to
carbon nanotubes (CNTs) are measured. We demonstrate that the PSI forms active
electronic junctions with the CNTs enabling control of the CNTs
photoconductance by the PSI. In order to electrically contact the photoactive
proteins, a cysteine mutant is generated at one end of the PSI by genetic
engineering. The CNTs are covalently bound to this reactive group using
carbodiimide chemistry. We detect an enhanced photoconductance signal of the
hybrid material at photon wavelengths resonant to the absorption maxima of the
PSI compared to nonresonant wavelengths. The measurements prove that it is
feasible to integrate photosynthetic proteins into optoelectronic circuits at
the nanoscale
The influence of size effect on the electronic and elastic properties of diamond films with nanometer thickness
The atomic structure and physical properties of few-layered oriented
diamond nanocrystals (diamanes), covered by hydrogen atoms from both sides are
studied using electronic band structure calculations. It was shown that energy
stability linear increases upon increasing of the thickness of proposed
structures. All 2D carbon films display direct dielectric band gaps with
nonlinear quantum confinement response upon the thickness. Elastic properties
of diamanes reveal complex dependence upon increasing of the number of
layers. All theoretical results were compared with available experimental data.Comment: 16 pages, 5 figures, 3 table
Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial
PURPOSE Antitumor activity in preclinical models and a phase I study of patients with dedifferentiated liposarcoma (DD-LPS) was observed with selinexor. We evaluated the clinical benefit of selinexor in patients with previously treated DD-LPS whose sarcoma progressed on approved agents. METHODS SEAL was a phase II-III, multicenter, randomized, double-blind, placebo-controlled study. Patients age 12 years or older with advanced DD-LPS who had received two-five lines of therapy were randomly assigned (2:1) to selinexor (60 mg) or placebo twice weekly in 6-week cycles (crossover permitted). The primary end point was progression-free survival (PFS). Patients who received at least one dose of study treatment were included for safety analysis (ClinicalTrials.gov identifier: ). RESULTS Two hundred eighty-five patients were enrolled (selinexor, n = 188; placebo, n = 97). PFS was significantly longer with selinexor versus placebo: hazard ratio (HR) 0.70 (95% CI, 0.52 to 0.95; one-sided P = .011; medians 2.8 v 2.1 months), as was time to next treatment: HR 0.50 (95% CI, 0.37 to 0.66; one-sided P < .0001; medians 5.8 v 3.2 months). With crossover, no difference was observed in overall survival. The most common treatment-emergent adverse events of any grade versus grade 3 or 4 with selinexor were nausea (151 [80.7%] v 11 [5.9]), decreased appetite (113 [60.4%] v 14 [7.5%]), and fatigue (96 [51.3%] v 12 [6.4%]). Four (2.1%) and three (3.1%) patients died in the selinexor and placebo arms, respectively. Exploratory RNA sequencing analysis identified that the absence of CALB1 expression was associated with longer PFS with selinexor compared with placebo (median 6.9 v 2.2 months; HR, 0.19; P = .001). CONCLUSION Patients with advanced, refractory DD-LPS showed improved PFS and time to next treatment with selinexor compared with placebo. Supportive care and dose reductions mitigated side effects of selinexor. Prospective validation of CALB1 expression as a predictive biomarker for selinexor in DD-LPS is warranted. (C) 2022 by American Society of Clinical Oncolog
The prince of Denmark facing mass immigration β from Germany.
How would Denmark react to a wave of mass immigration from Germany, numbering hundreds of thousands or millions of people? The question is, needles to say, purely hypothetical, but it is nevertheless, in my view, highly pertinent in the context of discussing the issues raised in Liav Orgadβs important book, The Cultural Defense of Nations. These questions are at the very heart of Europeβs present concerns and dilemmas, which makes the bookβs highly original, learned and well-argued contribution to the debate all the more valuable.</p
ΠΡΠ±ΠΎΡΡ ΠΈ ΠΏΡΠ΅Π΄Π²ΡΠ±ΠΎΡΠ½ΡΠ΅ ΠΊΠ°ΠΌΠΏΠ°Π½ΠΈΠΈ Π² Π ΠΈΠΌΠ΅: ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΏΠΎΠ·Π΄Π½Π΅ΠΉ Π Π΅ΡΠΏΡΠ±Π»ΠΈΠΊΠΈ
ΠΠ½ΠΈΠ³Π° ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΡΠΎΠ±ΠΎΠΉ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΈΠΌΡΠΊΠΈΡ
Π²ΡΠ±ΠΎΡΠΎΠ² ΠΈ ΠΏΡΠ΅Π΄Π²ΡΠ±ΠΎΡΠ½ΠΎΠΉ Π°Π³ΠΈΡΠ°ΡΠΈΠΈ Π² ΠΏΠ΅ΡΠΈΠΎΠ΄ ΠΏΠΎΠ·Π΄Π½Π΅ΠΉ Π Π΅ΡΠΏΡΠ±Π»ΠΈΠΊΠΈ, ΠΏΠΎΡΠ²ΡΡΡΠ½Π½ΠΎΠ΅ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌ ΡΠΏΠΎΡΠΎΠ±Π°ΠΌ Π·Π°Π²ΠΎΠ΅Π²Π°Π½ΠΈΡ ΡΠ»Π΅ΠΊΡΠΎΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΠΈ ΠΈ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΠΎΠ±Π΅Π΄Ρ ΠΏΡΠΈ Π³ΠΎΠ»ΠΎΡΠΎΠ²Π°Π½ΠΈΠΈ. Π Π΅ΡΡ Π² Π½Π΅ΠΉ ΠΈΠ΄ΡΡ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ ΠΎ ΡΠΎΠΈΡΠΊΠ°Π½ΠΈΠΈ Π² ΡΠ·ΠΊΠΎΠΌ ΡΠΌΡΡΠ»Π΅ ΡΡΠΎΠ³ΠΎ ΡΠ»ΠΎΠ²Π°, Π½ΠΎ ΠΈ ΠΎ ΠΊΠ°ΠΆΠ΄ΠΎΠΌ Π²ΠΈΠ΄Π΅ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΡΠΎ ΡΡΠΎΡΠΎΠ½Ρ ΠΊΠ°Π½Π΄ΠΈΠ΄Π°ΡΠ° β Π΄Π΅ΠΉΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΌ ΠΈΠ»ΠΈ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»Π°Π³Π°Π΅ΠΌΠΎΠΌ β ΠΊΠΎΡΠΎΡΡΠ΅, ΠΊΠ°ΠΊ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»Π°Π³Π°Π»ΠΎΡΡ, ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π»ΠΈ Π΅Π³ΠΎ ΡΠ°Π½ΡΡ Π½Π° ΠΏΡΠΎΡ
ΠΎΠΆΠ΄Π΅Π½ΠΈΠ΅ cursus honorum. ΠΠΎΠΏΡΠΎΡ ΠΎ ΡΠΈΠΌΡΠΊΠΈΡ
Π²ΡΠ±ΠΎΡΠ°Ρ
ΠΏΠΎΠΌΠ΅ΡΠ°Π΅ΡΡΡ, ΡΠ°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, Π² Π±ΠΎΠ»Π΅Π΅ ΡΠΈΡΠΎΠΊΠΈΠΉ ΠΏΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΈ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΡΠΉ ΠΊΠΎΠ½ΡΠ΅ΠΊΡΡ. ΠΠ΄Π½ΠΎΠΉ ΠΈΠ· ΡΠ΅Π»Π΅ΠΉ Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΠ΅ΡΠ΅ΠΎΡΠ΅Π½ΠΊΠ° ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΡΠΈΠΌΡΠΊΠΎΠΉ ΠΈΠ·Π±ΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ. ΠΠ²ΡΠΎΡ Π΄Π΅Π»Π°Π΅Ρ Π²ΡΠ²ΠΎΠ΄, ΡΡΠΎ Π²Π°ΠΆΠ½ΠΎΡΡΡ Π½Π°ΡΠΎΠ΄Π½ΠΎΠ³ΠΎ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ° Π² ΡΡΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΠ΅ Π±ΡΠ»Π° Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ Π±ΠΎΠ»ΡΡΠ΅ΠΉ, ΡΠ΅ΠΌ ΡΠ°ΡΡΠΎ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»Π°Π³Π°ΡΡ.Bibliography: P. 235-246; Index: P. 247-251
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