8 research outputs found
AlN/AlGaN HEMTs on AlN substrate for stable high-temperature operation
We demonstrate an AlN/AlGaN high-electron-mobility transistor (HEMT) fabricated on a free-standing AlN substrate. A metal stack,
composed of Zr/Al/Mo/Au, was found to show low contact resistivity for source and drain ohmic contacts. The fabricated AlN/AlGaN HEMT
exhibited a maximum drain current of 38 mA/mm with a threshold voltage of -3.4 V. Negligible drain current degradation was observed at temperatures from 300 to 573 K, emonstrating that our AlN/AlGaN approach on an AlN substrate is promising for stable high-temperature operation
Analysis of Risk Factors in Human Bioequivalence Study That Incur Bioinequivalence of Oral Drug Products
Improving the estimation of parameter uncertainty distributions in nonlinear mixed effects models using sampling importance resampling
Myeloid derived suppressor cells contribute to the malignant progression of oral squamous cell carcinoma
Reconnaissance report of Kobe Univ. RCUSS geo-hazard team to India
<div><p>Objective</p><p>The perception of pain is susceptible to modulation by psychological and contextual factors. It has been shown that subjects judge noxious stimuli as more painful in a respective suggestive context, which disappears when the modifying context is resolved. However, a context in which subjects judge the painfulness of a nociceptive stimulus in exactly the opposite direction to that of the cues has never been shown so far.</p><p>Methods</p><p>Nociceptive stimuli (300 ms intranasal gaseous CO<sub>2</sub>) at the individual pain threshold level were applied after a visual cue announcing the stimulus as either âno painâ, merely a âstimulusâ, or âpainâ. Among the stimuli at threshold level, other CO<sub>2</sub> stimuli that were clearly below or above pain threshold were randomly interspersed. These were announced beforehand in 12 subjects randomly with correct or incorrect cues, i.e., clearly painful or clearly non-painful stimuli were announced equally often as not painful or painful. By contrast, in a subsequent group of another 12 subjects, the stimuli were always announced correctly with respect to the evoked pain.</p><p>Results</p><p>The random and often incorrect announcement of stimuli clearly below or above pain threshold caused the subjects to rate the stimuli at pain-threshold level in the opposite direction of the cue, i.e., when the stimuli were announced as âpainâ significantly more often than as non-painful and vice versa (p < 10<sup>-4</sup>). By contrast, in the absence of incongruence between announcement and perception of the far-from-threshold stimuli, stimuli at pain threshold were rated in the cued direction.</p><p>Conclusions</p><p>The present study revealed the induction of associations incongruent with a given message in the perception of pain. We created a context of unreliable cues whereby subjects perceived the stimulus opposite to that suggested by a prior cue, i.e., potentially nociceptive stimuli at pain threshold level that were announced as painful were judged as non-painful and vice versa. These findings are consistent with reported data on the effects of distrust on non-painful cognitive responses.</p></div