Genetic modifiers of cognitive maintenance among older adults.

ObjectiveIdentify genetic factors associated with cognitive maintenance in late life and assess their association with gray matter (GM) volume in brain networks affected in aging.MethodsWe conducted a genome-wide association study of ∼2.4 M markers to identify modifiers of cognitive trajectories in Caucasian participants (N = 7,328) from two population-based cohorts of non-demented elderly. Standardized measures of global cognitive function (z-scores) over 10 and 6 years were calculated among participants and mixed model regression was used to determine subject-specific cognitive slopes. "Cognitive maintenance" was defined as a change in slope of ≥ 0 and was compared with all cognitive decliners (slope < 0). In an independent cohort of cognitively normal older Caucasians adults (N = 122), top association findings were then used to create genetic scores to assess whether carrying more cognitive maintenance alleles was associated with greater GM volume in specific brain networks using voxel-based morphometry.ResultsThe most significant association was on chromosome 11 (rs7109806, P = 7.8 × 10(-8)) near RIC3. RIC3 modulates activity of α7 nicotinic acetylcholine receptors, which have been implicated in synaptic plasticity and beta-amyloid binding. In the neuroimaging cohort, carrying more cognitive maintenance alleles was associated with greater volume in the right executive control network (RECN; PFWE  = 0.01).ConclusionsThese findings suggest that there may be genetic loci that promote healthy cognitive aging and that they may do so by conferring robustness to GM in the RECN. Future work is required to validate top candidate genes such as RIC3 for involvement in cognitive maintenance

Large N Quantum Time Evolution Beyond Leading Order

For quantum theories with a classical limit (which includes the large N limits of typical field theories), we derive a hierarchy of evolution equations for equal time correlators which systematically incorporate corrections to the limiting classical evolution. Explicit expressions are given for next-to-leading order, and next-to-next-to-leading order time evolution. The large N limit of N-component vector models, and the usual semiclassical limit of point particle quantum mechanics are used as concrete examples. Our formulation directly exploits the appropriate group structure which underlies the construction of suitable coherent states and generates the classical phase space. We discuss the growth of truncation error with time, and argue that truncations of the large-N evolution equations are generically expected to be useful only for times short compared to a ``decoherence'' time which scales like N^{1/2}.Comment: 36 pages, 2 eps figures, latex, uses revtex, epsfig, float

From Instantons to Sphalerons: Time-Dependent Periodic Solutions of SU(2)-Higgs Theory

We solve numerically for periodic, spherically symmetric, classical solutions of SU(2)-Higgs theory in four-dimensional Euclidean space. In the limit of short periods the solutions approach tiny instanton-anti-instanton superpositions while, for longer periods, the solutions merge with the static sphaleron. A previously predicted bifurcation point, where two branches of periodic solutions meet, appears for Higgs boson masses larger than $3.091 M_W$.Comment: 14 pages, RevTeX with eps figure

Non-perturbative equivalences among large N gauge theories with adjoint and bifundamental matter fields

We prove an equivalence, in the large N limit, between certain U(N) gauge theories containing adjoint representation matter fields and their orbifold projections. Lattice regularization is used to provide a non-perturbative definition of these theories; our proof applies in the strong coupling, large mass phase of the theories. Equivalence is demonstrated by constructing and comparing the loop equations for a parent theory and its orbifold projections. Loop equations for both expectation values of single-trace observables, and for connected correlators of such observables, are considered; hence the demonstrated non-perturbative equivalence applies to the large N limits of both string tensions and particle spectra.Comment: 40 pages, JHEP styl

The Use of Senior Volunteers in the Care of Discharged Geriatric Patients

This article reports on a project that utilized senior volunteers in the role of health advocates for geriatric patients discharged from a hospital. The project was evaluated to determine if healthy and active seniors could make a contribution to the health and social welfare of such discharged elderly persons. The study was conducted in Montreal, Canada and funded by a federal grant from Health Canada. The research collaborators came from a 414-bed secondary care university-affiliated community hospital, a community social service agency with a mandate to respond to the needs of its frail elderly constituents, and a university-based research centr

Quark-Gluon Plasma - New Frontiers

As implied by organizers, this talk is not a conference summary but rather an outline of progress/challenges/``frontiers'' of the theory. Some fundamental questions addressed are: Why is sQGP such a good liquid? Do we understand (de)confinement and what do we know about ``magnetic'' objects creating it? Can we understand the AdS/CFT predictions, from the gauge theory side? Can they be tested experimentally? Can AdS/CFT duality help us understand rapid equilibration/entropy production? Can we work out a complete dynamical ``gravity dual'' to heavy ion collisions?Comment: final talk at Quark Matter 2008, Jaipur, India, Feb.200

One-Loop Quantum Energy Densities of Domain Wall Field Configurations

We discuss a simple procedure for computing one-loop quantum energies of any static field configuration that depends non-trivially on only a single spatial coordinate. We specifically focus on domain wall-type field configurations that connect two distinct minima of the effective potential, and may or may not be the solutions of classical field equations. We avoid the conventional summation of zero-point energies, and instead exploit the relation between functional determinants and solutions of associated differential equations. This approach allows ultraviolet divergences to be easily isolated and extracted using any convenient regularization scheme. Two examples are considered: two-dimensional $\phi^4$ theory, and three-dimensional scalar electrodynamics with spontaneous symmetry breaking at the one-loop level.Comment: RevTex, 29 pages, 1 figure, minor corrections, references adde

On Axially Symmetric Solutions in the Electroweak Theory

We present the general ansatz, the energy density and the Chern-Simons charge for static axially symmetric configurations in the bosonic sector of the electroweak theory. Containing the sphaleron, the multisphalerons and the sphaleron-antisphaleron pair at finite mixing angle, the ansatz further allows the construction of the sphaleron and multisphaleron barriers and of the bisphalerons at finite mixing angle. We conjecture that further solutions exist.Comment: 17 pages, latex, THU-94/0