Multivariate analysis in relation to breeding system in opium popy, Papaver somniferum L.

The opium poppy (Papaver somniferum L.) is an important medicinal plant of great pharmacopoel uses. 101 germplasm lines of different eco-geographical origin maintained at National Botanical Research Institute, Lucknow were evaluated to study the genetic divergence for seed yield/plant, opium yield/plant and its 8 component traits following multivariate and canonical analysis. The genotypes were grouped in 13 clusters and confirmed by canonical analysis. Sixty eight percent genotypes (69/101) were genetically close to each other and grouped in 6 clusters (II, III, IV, V, VIII, XII) while apparent diversity was noticed for 32 percent (32/101) of the genotypes who diversed into rest 7 clusters (I, VI, VII, IX, X, XI, XIII). Inter cluster distance ranged from 47.28 to 234.55. The maximum was between IX and X followed by VII and IX (208.30) and IX and XI (205.53). The genotypes in cluster IX, X. XI, and XII had greater potential as breeding stock by virtue of high mean values of one or more component characters and high statistical distance among them. Based on findings of high cluster mean of component trait and inter-cluster distance among clusters, a breeding plan has been discussed

Fuzzy Closure Spaces vs. Fuzzy Rough Sets

AbstractThis paper investigates the relationship among fuzzy rough sets, fuzzy closure spaces and fuzzy topology. It is shown that there exists a bijective correspondence between the set of all fuzzy reflexive approximation spaces and the set of all quasi-discrete fuzzy closure spaces satisfying a certain extra condition. Similar correspondence is also obtained between the set of all fuzzy tolerance approximation spaces and the set of all symmetric quasi-discrete fuzzy closure spaces satisfying a certain extra condition

Performance Investigation of Nylon-Kevlar Ringslot Parachute

Kevlar material is being used in parachute systems require high strength-to-weight ratios or becoming resistance to sustain high temperatures. However, Nylon-Kevlar parachutes are popular these days and are first preference of the parachute designers specially for recovery system of reentry vehicles. Tests of using Kevlar suspension lines, radials, vent and skirt re-enforcements, risers demonstrated that the Kevlar material can be used successfully in Ringslot parachute. The opening shock experienced by the parachute does not differ from all-Nylon parachutes. The parachute is much lighter and capable of withstanding higher load and therefore can be used for extraction or deceleration in recovery system of reentry vehicles. The design and performance of a hybrid Ringslot was investigated experimentally in sled test. The experimental method and performance data are described in this paper.Defence Science Journal, Vol. 64, No. 4, July 2014, pp. 406-410, DOI:http://dx.doi.org/10.14429/dsj.64.4950

Synthesis, Characterization and Antimicrobial Screening of Novel Hydrazide Ligand & It’s Transition Metal Complexes

Published ArticleDifferent transition metal complexes were synthesized from novel 3-bromo-2-[1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3- yl)ethylidene]hydrazide ligand (H2L) and characterized by spectral techniques. The synthesized ligand was found to act mono as well as di deprotonated (OH, NH) manner and stoichiometry of the ligand to metal ions was confirmed to be 1:1 in case of complex using metal chloride salts, whereas 1:2 in case of metal(II) complexes using metal acetate(II) salt. Structures of metal complexes were confirmed by IR, 1H NMR, TGA, XRD, elemental analysis and UV technique which revealed that Mn(II), Co(II), Ni(II), Cu(II) complexes were octahedral geometry and those of Cu(II), Zn(II) showed square planner and tetrahedral geometry around metal ion respectively. Furthermore H2L and its metal complexes were screened for antimicrobial activity which showed that ligand enhanced its biological activity after coordination with metal ions. In particular, Cd(II) and Mn(II) complexes exhibited excellent antifungal activity

DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding

DOT1L methylates histone H3 lysine 79 during transcriptional elongation and is stimulated by ubiquitylation of histone H2B lysine 120 (H2BK120ub) in a classical trans-histone crosstalk pathway. Aberrant genomic localization of DOT1L is implicated in mixed lineage leukemia (MLL)-rearranged leukemias, an aggressive subset of leukemias that lacks effective targeted treatments. Despite recent atomic structures of DOT1L in complex with H2BK120ub nucleosomes, fundamental questions remain as to how DOT1L-ubiquitin and DOT1L-nucleosome acidic patch interactions observed in these structures contribute to nucleosome binding and methylation by DOT1L. Here, we combine bulk and single-molecule biophysical measurements with cancer cell biology to show that ubiquitin and cofactor binding drive conformational changes to stimulate DOT1L activity. Using structure-guided mutations, we demonstrate that ubiquitin and nucleosome acidic patch binding by DOT1L are required for cell proliferation in the MV4; 11 leukemia model, providing proof of principle for MLL targeted therapeutic strategies

Community seed banks as seed producers: Cases from India, Nepal, Uganda and Zimbabwe

Community-based seed producers are a relatively under-researched and under-documented category of seed producers, but have the potential to cater to the diverse seed needs and interests of smallholder farmers. This working paper presents a number of such community-seed producers, with a focus on community seed banks. The case studies from India, Nepal, Uganda and Zimbabwe point to the viability of community seed banks as seed producers and distributors, but becoming successful is not easy and depends on several factors, including initial technical guidance and support, sufficient time, adherence to a seed value chain perspective and the development of a sound business plan from the very start

First measurement of Ωc0 production in pp collisions at s=13 TeV

The inclusive production of the charm–strange baryon 0 c is measured for the first time via its hadronic √ decay into −π+ at midrapidity (|y| <0.5) in proton–proton (pp) collisions at the centre-of-mass energy s =13 TeV with the ALICE detector at the LHC. The transverse momentum (pT) differential cross section multiplied by the branching ratio is presented in the interval 2 < pT < 12 GeV/c. The pT dependence of the 0 c-baryon production relative to the prompt D0-meson and to the prompt 0 c-baryon production is compared to various models that take different hadronisation mechanisms into consideration. In the measured pT interval, the ratio of the pT-integrated cross sections of 0 c and prompt + c baryons multiplied by the −π+ branching ratio is found to be larger by a factor of about 20 with a significance of about 4σ when compared to e+e− collisions