Thyroid abnormality in abnormal uterine bleeding: an observational study from Medical College in Western UP, India

Background: Abnormal Uterine Bleeding (AUB) is one of the commonest gynecological complain in reproductive age group. Menstrual abnormalities are commonly seen when there is any alteration in thyroid function. Objective of present study was to investigate the prevalence of AUB and to determine the menstrual pattern in cases with thyroid dysfunction.Methods: The present cross sectional observational study was conducted Teerthankar Mahaveer Medical College and Research Center Moradabad. Total 400 cases presenting with AUB were included in the study. Routine blood test, ultrasonography and thyroid function tests were done in these cases.Results: Among all the cases presenting with menstrual abnormalities 26% had hypothyroidism and 9% have hyperthyroidism and rest had euthyroid status. Menorrhagia (45.2%) and polymenorrhoea (37.5%) were commonest menstrual abnormality seen in cases with hypothyroidism. Most cases with hyperthyroidism presented with hypomenorrhoea (27.8%).Conclusions: Thyroid function abnormality is common in cases presenting with AUB and it gets relieved in correcting hormonal imbalance

An analytical study of intraoperative, immediate post-operative and perinatal complications in previous two caesarean section

Background: Lower segment caesarean section is one of the commonest operations performed now a day.It has been seen that in cases with previous caesarean section there is increased maternal morbidity and mortality due to placenta previa, adherent placenta and caesarean hysterectomy.The present study was conducted to know the fetomaternal outcome and intra and immediate post-operative complications in cases with previous two lower segment caesarean section.Methods: The present study was conducted in TMMC Moradabad between January 2017-January 2018.Total 68 cases were previous two lower segment caesarean section were included in the study. Neonatal outcome and intraoperative and immediate postoperative complications were seen in these cases.Results: In the present study majority of the cases were in 30-34 years age group (39.7%), the maximum number of caesarean sections were done between gestational age of 37-39.6 weeks (47.1%). Intraoperatively adhesions between uterus, anterior abdominal wall and bladder was seen in less than half of the cases i.e. in 42.6% cases. Out of 68 cases with previous two lower segment caesarean operated 13 cases had placenta previa and 4 cases had adherent placenta.Conclusions: The present study shows that the maternal and perinatal morbidity and mortality is increased with increasing number of caesarean sections. So, there should be reduction in rate of primary caesarean section which can reduce the rate of placenta previa and adherent placenta in subsequent pregnancies

MRI brain findings of cerebral malaria in children with acute encephalitis syndrome: a prospective study in 60 patients

Background: Acute encephalitis syndrome (AES) is defined as a person of any age group, at any time of the year with the acute onset of fever and change in mental sensorium (including confusion, disorientation, coma or inability to talk) and/or new onset of convulsions (excluding febrile seizures). Encephalitis is a inflammation of brain tissue which presents as a diffuse and/or a focal neuropsychological dysfunction and inflammation of adjacent meningitis. Objectives were to determine clinicoepidemiological profile in AES with special to reference cerebral malaria and to study various MRI findings in patients of AES especially in cerebral malaria.Methods: A prospective study of all cases of fever with unconsciousness or altered sensorium with or without convulsions admitted in PICU of MYH and CNBC Indore. Inclusion criteria was all those children who were previously neurologically normal, of age 1-14 years, patients with fever (6 in most cases, fundus abnormality and meningeal irritation was absent in all cases of cerebral malaria. MRI of brain in cerebral malaria was mostly normal, in (47.05%), second most common we get hyperintensity in periventricular and corpus callosum areas (23.52%), hyperintensity in basal ganglia and thalamus was found in17.64% cases and white matter changes in 2 cases. The final outcome of all cerebral cases was good, all were discharged, and there was no mortality.Conclusions: Our result demonstrate that cerebral malaria is a common cause of acute febrile encephalopathy in children. Presence of plasmodium falciparum is essential for diagnosis of cerebral malaria. No specific lesions have been identified in MRI brain. 

AN ANALYTICAL STUDY OF PRAJASTHAPAN MAHAKASHAYA ON VANDHYATWA W. S. R. TO FEMALE INFERTILITY

In Charaka samhita, among the fifty important decotives, Prajasthapan mahakashaya (fertility promoters) was introduced according its Doshaj prabhav (specific action) of the drugs and promotes strength and conceiving by removing Doshas to female reproductive system. These drugs are also having Rasayana properties, which improve the quality of all body elements. These herbs can be used all together or individually or in permutation combinations of each other on the patient's condition. In short, Prajasthapan mahakashaya can be used in all conditions involving obstruction in the path of conception and help in fixing or lead to excellence in progeny. Female Vandhyatwa (Infertility) may cause twenty Yoni vyapad (gynaecological disorders), infections, weakness, psycological factors like anxiety, depression etc., may leads disturbance in the Ritu (fertile period), Ambu (nourishment for developing the zygote), Beeja (activated ovum), Kshetra (Physiological maturity and healthy organs of reproductive system). The objective of the present study is an analytical study of Prajasthapak mahakashay on Vandhyatwa with special reference to female infertility and to analyse all ten drugs of Prajasthapan Mahakashaya to collect the information on latest studies on above mentioned factors

Lipemic sample: Is it worth our attention?

A 27-year-old male presented to the emergency room with abdominal pain and vomiting. While investigating, the blood sample collected was densely lipemic and repeatedly rejected by the analyzer. On deliberation, the sample was subjected to dilution and results showed hyperglycemia, hypertriglyceridemia (HTG) (>4000 mg/dL), and hyperamylasemia. Acute pancreatitis (AP) was confirmed on computed tomography scan of the abdomen. Lipemic sample while investigating abdominal pain in either pregnant women or patients with diabetes mellitus, hormone disorders, or chronic alcoholism, must prompt the diagnosis of AP (HTG induced pancreatitis). The laboratory should be aware of sample artifacts and efforts should be taken to convey the findings (both physical and biochemical) to the clinician. This case stresses the need for good communication between treating clinical and diagnostic faculties

Inverse QSAR approach and Molecular docking studies to design novel methoxy substituted Chalcones and their Computational Anticancer activity evaluation

Abstract Quantitative structure activity-relationship (QSAR

Transaminitis among Patients with Dengue Fever Visiting a Tertiary Care Centre

Introduction: Transaminitis is a condition where serum aspartate transaminase and alanine transaminase increase indicating liver dysfunction. One such disease where liver involvement might be observed is dengue, which is a mosquito-borne viral infection. The aim of the study was to find out the prevalence of transaminitis among patients with dengue fever in a tertiary care centre. Methods: A descriptive cross-sectional study was conducted in a tertiary care centre from 1 November 2022 to 31 March 2023 after obtaining ethical approval from the Institutional Review Committee. Informed written consent was taken before collecting the data. A rapid immunochromatography test was used to confirm dengue infection. Serum aspartate transaminase and alanine transaminase were measured through routine Reitman and Frankel’s enzymatic method. Dengue-confirmed patients from the medical outpatient department, fever clinic, and medical ward of the centre were included in the study. Patients with known prior liver diseases or any other chronic diseases, pregnancy, and patients in the hospice unit were excluded. Convenience sampling method was used. The point estimate was calculated at a 95% Confidence Interval. Results: Among 442 dengue infected patients, the prevalence of transaminitis was 188 (42.53%) (37.92-47.13, 95% Confidence Interval). The highest frequency of dengue positive was observed among the 18-35 years age group, which was 97 (51.59%) with male predominance 134 (71.27%). Conclusions: The prevalence of transaminitis among patients with dengue fever in a tertiary care centre was found to be lower than other studies done in similar settings

Genome wide association analysis for grain micronutrients and anti-nutritional traits in mungbean [Vigna radiata (L.) R. Wilczek] using SNP markers

Mungbean is an important food grain legume for human nutrition and nutritional food due to its nutrient-dense seed, liked palatability, and high digestibility. However, anti-nutritional factors pose a significant risk to improving nutritional quality for bio fortification. In the present study, genetic architecture of grain micronutrients (grain iron and zinc concentration) and anti-nutritional factors (grain phytic acid and tannin content) in association mapping panel of 145 diverse mungbean were evaluated. Based on all four parameters genotypes PUSA 1333 and IPM 02-19 were observed as desired genotypes as they had high grain iron and zinc concentration but low grain phytic acid and tannin content. The next generation sequencing (NGS)-based genotyping by sequencing (GBS) identified 14,447 genome-wide SNPs in a diverse selected panel of 127 mungbean genotypes. Population admixture analysis revealed the presence of four different ancestries among the genotypes and LD decay of ∼57.6 kb kb physical distance was noted in mungbean chromosomes. Association mapping analysis revealed that a total of 20 significant SNPs were shared by both GLM and Blink models associated with grain micronutrient and anti-nutritional factor traits, with Blink model identifying 35 putative SNPs. Further, this study identified the 185 putative candidate genes. Including potential candidate genes Vradi07g30190, Vradi01g09630, and Vradi09g05450 were found to be associated with grain iron concentration, Vradi10g04830 with grain zinc concentration, Vradi08g09870 and Vradi01g11110 with grain phytic acid content and Vradi04g11580 and Vradi06g15090 with grain tannin content. Moreover, two genes Vradi07g15310 and Vradi09g05480 showed significant variation in protein structure between native and mutated versions. The identified SNPs and candidate genes are potential powerful tools to provide the essential information for genetic studies and marker-assisted breeding program for nutritional improvement in mungbean

Strategies for identifying stable lentil cultivars (Lens culinaris Medik) for combating hidden hunger, malnourishment, and climate variability

Iron and zinc malnutrition is a global humanitarian concern that mostly affects newborns, children, and women in low- and middle-income countries where plant-based diets are regularly consumed. This kind of malnutrition has the potential to result in a number of immediate and long-term implications, including stunted growth, an elevated risk of infectious diseases, and poor development, all of which may ultimately cause children to not develop to the fullest extent possible. A determination of the contributions from genotype, environment, and genotype by environment interactions is necessary for the production of nutrient-dense lentil varieties that offer greater availability of iron and zinc with a high level of trait stability. Understanding the genotype and environmental parameters that affect G x E (Genotype x Environment) interactions is essential for plant breeding. We used GGE(Genotype, Genotype x Environment interactions) and AMMI (Additive Main effects and Multiplicative Interaction) models to study genetic stability and GE(Genotype x Environment interactions) for grain Fe, Zn, Al, and anti-nutritional factors like phytic acid content in sixteen commercially produced lentil cultivars over several different six geographical locations across India. Significant genetic variability was evident in the Fe and Zn levels of different genotypes of lentils. The amounts of grain iron, zinc, and phytic acid varied from 114.10 to 49.90 mg/kg, 74.62 to 21.90 mg/kg, and 0.76 to 2.84 g/100g (dw) respectively. The environment and GE (Genotype x Environment interactions) had an impact on the concentration of grain Fe, Zn, and phytic acid (PA). Heritability estimations ranged from low to high (53.18% to 99.48%). The study indicated strong correlation between the contents of Fe and Zn, a strategy for simultaneously increasing Fe and Zn in lentils may be recommended. In addition, our research revealed that the stable and ideal lentil varieties L4076 (Pusa Shivalik) for Fe concentration and L4717 (Pusa Ageti) for Zn content, which have lower phytic acid contents, will not only play an essential role as stable donors in the lentil bio-fortification but will also enable the expansion of the growing area of bio-fortified crops for the security of health and nutrition

DEVADARU (CEDRUS DEODARA (ROXB.) LOUD.): A CRITICAL REVIEW ON THE MEDICINAL PLANT

Devadaru (Cedrus deodara) an important plant belongs to Pinaceae family found in the north-western Himalayas at altitude of 1200-3000 meter. The aromatic wood of this beautiful tree is used as carminative, anti inflammatory, diaphoretic, diuretics, antipyretic, antileprotic. In Caraka samhita it is one among the Satanya shodhana and Anuvasanopaga group of drugs and Sushruta also considered it as the Vata Shamana group, Katuvarga and Eladi group. It is the chief timber of north west India and is used for all purpose of construction of railway sleepers, bridges, and even for furniture and shingles. The oil obtained is used for mange in horses and sore feet in cattle. It is in use since vedic period in temples and in making incense even said that by sitting under its shade many diseases cures especially asthma. Here the present review study is an attempt to provide reported detail information of this herb from various Samhitas and its study in modern area like its phytoconstituents and pharmacological activities