IN-SILICO PREDICTION AND DOCKING STUDIES OF NOVEL SYNTHESIZED BENZOFURAN DERIVATIVES AS ANTI-CANCER ACTIVITY

Amendment on the benzofuran moiety has resulted a various types of derivatives with various biological activities including anticancer and antibacterial activity. With the findings of identifying new anticancer agent an investigation has been done to hybridize various heterocyclic moieties.   In this research article I have discussed the molecular docking study of our prepared benzofuran derivatives. Ten novel benzofuran derivatives were subjected to in-silico molecular docking studies to determine the affinity of novel benzofuran derivatives for anticancer targets. The Molecular docking study  is the study of how two or more molecular structure (Example- drugs, enzymes and proteins) collaborate with each other. Mainly ten types of benzofuran derivatives (M5a-M5j) were synthesized from (7-chlorobenzofuran-3-yl)hydrazine with substituted benzaldehyde in the presence of sodium acetate at 700C at reflux for docking studies. In drug discovery, docking is the genuine pathway for the molecular interaction of compounds. For the study of molecular docking we have used numerous software’s such as molinspiration cheminformatics , swiss target prediction, Chem draw 3D.16.0, PyMOL , Discovery studio, rcsb PDB ,SwissADME  and Auto dock vina 1.5.7. By the use of these software’s we have estimated the result of our synthesized compounds in the form of binding energy. Novel molecules were privileged on the base of lowest binding energy (-6.9 to -10.4 Calorie/mol) All the novel synthetic derivatives (M5a-M5j) has shown a best negative energy. On the basis of our studies we have concluded that all these prepared compound may be important Pharmacophore against anti-cancer activity

Synchronous endometrial and ovarian cancer: a rare presentation

Synchronous primary cancers are relatively uncommon in the general population. About 0.5 -1.7% of gynecological malignancies have synchronous primary cancer of female genital tract. Amongst the synchronous gynecological malignancies synchronous endometrioid carcinoma is most common and has good prognosis. Patients with synchronous endometrioid tumors of endometrium and ovary are usually younger, have low grade number, and their prognosis is better than other histologic types. The authors are presenting a case of 38 years old nulliparous obese woman with pain in abdomen and heavy menstrual bleeding for a duration of four months. The MRI pelvis was suggestive of well defined, lobulated, complex, solid cystic multiseptated lesion measuring 8.8×7.7×8.8 cm in right adnexa, with anteverted uterus, and a bulky indistinct emdomyometrial junction. Histopathology revealed synchronous endometrial carcinoma of both uterus and ovary

Knowledge, attitudes, and practices regarding HIV/AIDS among pregnant females attending the antenatal clinic: a study at Dr. S. N. Medical College in Jodhpur, India

Background: AIDS, caused by HIV, is a global health threat that weakens the immune system and leads to life-threatening infections. India has been heavily affected by the HIV/AIDS epidemic due to a lack of accurate information and prevention efforts. Mother-to-child transmission (MTCT) is a significant factor in HIV spread. Knowledge of HIV status through voluntary counseling and testing (VCT) is crucial. Despite efforts, HIV/AIDS remains a major public health challenge in India. Methods: A study at Dr. S.N. Medical College focused on pregnant women in the antenatal clinic. Using a questionnaire, data was collected from 100 participants on socio-demographics, HIV/AIDS knowledge, attitudes, and practices. Results: Most participants were aged 21-30, with 48 having 6-10 years of education. The majority identified as Hindu, and 89 were housewives. The study revealed gaps in HIV/AIDS knowledge, with many participants lacking awareness and having misconceptions. Stigma and fear were also prevalent, but recognition of abstinence as a preventive measure was observed. Conclusions: Targeted interventions, education, and awareness campaigns are necessary to enhance knowledge, dispel misconceptions, and reduce HIV/AIDS stigma among pregnant women in antenatal clinics. Policies, programs, and preventive strategies should be developed to reduce HIV/AIDS incidence and prevalence. Future research should address knowledge gaps, promote understanding of HIV/AIDS, and focus on preventing mother-to-child transmission, ultimately working towards ending AIDS as a public health threat

Exploring the role of serum β-HCG levels in predicting hypertensive disorders of pregnancy: a prospective observational study

Background: Hypertensive disorders of pregnancy pose significant risks to maternal and fetal health, contributing to global morbidity and mortality. Despite extensive research, these disorders remain a public health concern, necessitating the identification and prediction of associated risks for effective prevention and management. Methods: A prospective observational study was conducted in a hospital setting, involving 200 antenatal women visiting the Department of Obstetrics and Gynecology for routine checkups over a six-month period. Sample size calculation was based on expected sensitivity and prevalence rates. Inclusion criteria were defined, and clinical examinations were performed on the participants. Results: Higher serum β-HCG levels were significantly associated with hypertensive disorders of pregnancy. Low levels correlated with 12 out of 122 cases, while high levels correlated with 59 out of 78 cases. Two deaths were linked to hypertensive disorders. Age did not show a significant association, but variations were observed among religious groups. Conclusions: This study concludes that higher serum β-HCG levels are significantly associated with the development of hypertensive disorders of pregnancy. Age did not show a significant association with these disorders, suggesting the involvement of other contributing factors. The findings provide valuable insights for clinical management and further research in this field, contributing to a better understanding of the etiology and predictors of hypertensive disorders of pregnancy

Impact and Usage of Social Media in Business Sector during Covid-19 Pandemic

The Impact of covid-19 faced by whole world. The economic growth of all the countries is going down because of covid-19. In India, the covid-19 affected all the sectors but it mostly affected business sector. Social media is used in business sector, but during covid-19 pandemic situation social media is widely used in business sector for work effectively. The purpose of study is to determine the impact of social media on startup and growing business. The researcher wish to investigate how social Media influence on the growth of business and also to analyze which social media tools and application are used for effective work of business. Experiment were done on research data collected from the internet, Journal, Articles and personal prior knowledge. The result showed business sector are work or run effectively during pandemic situation. Most of business are used social media platform for example- Facebook, twitter, Instagram LinkedIn etc. Business sector are use social media platform for improving business both in quality and quantity. So, we conclude that, Business sector widely used social Media platform for effective and continuous work. This study is significant for Business Entrepreneur, Society, stakeholders, Government people and competitors. &nbsp

The Burden and Risk Factors of Reproductive Tract Infections among Married Women Aged 15-49 Years in Urban Slum of Agra Uttar Pradesh

Introduction: In developing countries, reproductive tract infection among women commonly goes undiagnosed and their sequel causes various complications. Objectives: To find out the prevalence of RTI/STI through a syndromic case approach and its correlates among women of reproductive age group. Material and Methods: A community-based cross-sectional study was carried out among 500 eligible married women residing in urban slums of Agra by using WHO Syndromic case approch for diagnosis of RTIs/STIs. Results: The overall prevalence of RTI/STD was found to be 32.80% where vaginal discharge (22.60%) and lower abdominal pain (8.20%) were the most common syndromes. On multivariate analysis, religion, caste, type of absorbent used during menses, and history of IUD use were found to be significantly significant. Conclusion: The result of this study highlights the high prevalence and potential risk factors that contribute to the occurrence of RTI. It also emphasizes the need of training and education session of the participants to identify the early symptoms of RTI

Risk factors influencing the bone health in perimenopausal and postmenopausal women

Background: Bone loss is being increasingly identified in premenopausal and early postmenopausal women. The significance of low bone mineral density (BMD) in females needs to be addressed. Female reproductive system plays a major role in regulating the bone loss from menarche to senescence. The purpose of our study is to identify the menstrual and reproductive factors that may lead to decreased bone mass during the premenopausal period so that early intervention could lead to improved bone health.Methods: The study was conducted on 100 women aged 40 - 60 years attending the outpatient department in Pandit Bhagwat Dayal Sharma PGIMS, Rohtak, Haryana, India. Their age, parity, body mass index, age at menarche, age at first pregnancy, duration of breast feeding, use of combined oral contraceptive, interpregnancy interval and BMD values were recorded. BMD was measured by dual- energy x-ray absorptiometry. Pearson test was used for correlation analysis. Comparison between the groups was conducted using analysis of variance (ANOVA) and Tukey’s test.Results: A significant negative correlation was established between parity, age at menarche, duration of breast feeding and BMD values. On the other hand, BMI and duration of oral contraceptive use showed a significant positive correlation with BMD values.Conclusions: Identification of risk factors for low BMD will provide the opportunity for early intervention to preventosteoporosis and will reduce the burden of unnecessary BMD testing in elderly age group for screening of osteoporosis

Rare case of vaginal leiomyoma in an adolescent girl: a diagnostic dilemma

Vaginal leiomyoma are very uncommon primary tumors of vagina. They are extremely rare in adolescent age group. They can have variable clinical presentations and could be difficult to diagnose at times in adolescents. We report an extremely rare and novel case of primary vaginal leiomyoma with hyaline degeneration in an adolescent girl which was primarily misdiagnosed as hematocolpos or vaginal malignancy due to its clinical presentation. A 14-year-old girl presented with complains of difficulty in passing urine and irregular vaginal bleeding. On per rectal examination an ill-defined bulge was felt anteriorly and altered chocolate color blood was coming out of vagina. Her ultrasonography report was suggestive of a cervicovaginal mass or hematocolpos. So, examination under anesthesia (EUA) was planned with probable diagnosis of hematocolpos due to secondary reasons or malignancy. On EUA a soft cystic vaginal mass was felt arising from the anterolateral wall obscuring the cervical os and cervix was felt behind it separately. Biopsy was taken from the mass which was confirmed histopathologically and immunohistochemically as vaginal leiomyoma with hyaline degeneration. Patient was managed successfully with complete tumor resection through vaginal approach followed by vaginal reconstruction. Though rare but the differential diagnosis of vaginal leiomyoma should always be kept in mind in adolescent girls presenting with vaginal mass and abnormal vaginal bleeding. Primary vaginal leiomyoma can be completely cured by surgery if diagnosed timely and appropriately so, should never be missed in adolescent age group

Association of Personality Trait with Auditory and Visual Reaction Time among Young Healthy Subjects

Background: Personality traits along with well-known factors like socioeconomic status and cognitive ability, predict important life outcomes such as health and lifespan, educational and occupational attainment, and may promote specific types of task effectiveness, which occurs in part via the processing of information. Reaction time provides an indirect index of the central nervous system’s integrity and processing ability. Material and Methods: The 111 healthy subjects (aged 17 -23 years) interviewed to pre-designed proforma regarding socio-demographic profile, “Glazer-Stress Control Lifestyle” questionnaire for personality trait and reaction time recorded by “Audio-Visual reaction time apparatus”. Statistical analysis was done using IBM SPSS Statistics 20, and the P-value <0.05 was considered significant. Results: The mean age of the study participants was 19.21±1.40 years, with a mean body mass index 20.65±4.32 kg/m2. Male subjects (68%) outnumbered the female participants (43%), and more than half of the subjects doing exercise. The nuclear family was the preferred mode of living belonging to class-II socioeconomic status (86%). The association of personality traits with auditory (low and high frequency) and visual (red and green light) reaction time was non-significant. Type-A personality subjects were maximum (13/20th), followed by Type-AB (6/20th) and least of Type-B personality (1/20th). Conclusion: The personality trait has no impact on auditory and visual reaction time. Though maximum participants belong to type A personality, still ambitious, proactive, and competitive nature does not influence the basic neurophysiological characteristics of the human body. Keywords: Auditory reaction time, Personality trait, Visual reaction tim