(De-)activating the growth machine for redevelopment: the case of Liede urban village in Guangzhou

This research investigates the mechanism of urban village redevelopment in south China. Through a revised typology of place entrepreneurs based on the growth machine thesis and a case study of Liede village in central Guangzhou, it illustrates how land-based interests embedded in an imbalanced power relationship can (de-)activate urban village redevelopment. The study reveals that while urban villagers, as represented by the village collective, have entrenched interests in the redevelopment process, the city government – as monopolistic land manager and place entrepreneur – plays the deciding role in forging and halting a growth machine geared towards urban village redevelopment. Although developers are also part of the process, the (de-)activation of redevelopment growth machine/coalition in Guangzhou has largely been dominated by the city government. With a comparative view on the original growth machine model, it is hoped that this study would furnish both theoretical and practical thoughts for future research

The role of climate in human mitochondrial DNA evolution: A reappraisal

AbstractPrevious studies have proposed that selection has been involved in the differentiation of human mitochondrial DNA (mtDNA) and climate was the main driving force. This viewpoint, however, gets no support from the subsequent studies and remains controversial thus far. To clarify this issue, a total of 237 complete mtDNA sequences belonging to autochthonous lineages from South Asia, Oceania, and East Asia were collected to seek for the imprint of selection. Based on nonsynonymous (N) and synonymous (S) substitutions analysis, our results confirmed that purifying selection was the predominant force during the evolution of human mtDNA. However, no significant and extensive difference was detected among these three regions, which did not support the climate adaptation hypothesis but preferred random genetic drift to be the main factor in shaping the current landscape of human mtDNA, at least those from Asian and Oceanian regions

Evolution of conserved secondary structures and their function in transcriptional regulation networks

<p>Abstract</p> <p>Background</p> <p>Many conserved secondary structures have been identified within conserved elements in the human genome, but only a small fraction of them are known to be functional RNAs. The evolutionary variations of these conserved secondary structures in human populations and their biological functions have not been fully studied.</p> <p>Results</p> <p>We searched for polymorphisms within conserved secondary structures and identified a number of SNPs within these elements even though they are highly conserved among species. The density of SNPs in conserved secondary structures is about 65% of that of their flanking, non-conserved, sequences. Classification of sites as stems or as loops/bulges revealed that the density of SNPs in stems is about 62% of that found in loops/bulges. Analysis of derived allele frequency data indicates that sites in stems are under stronger evolutionary constraint than sites in loops/bulges. Intergenic conserved secondary structures tend to associate with transcription factor-encoding genes with genetic distance being the measure of regulator-gene associations. A substantial fraction of intergenic conserved secondary structures overlap characterized binding sites for multiple transcription factors.</p> <p>Conclusion</p> <p>Strong purifying selection implies that secondary structures are probably important carriers of biological functions for conserved sequences. The overlap between intergenic conserved secondary structures and transcription factor binding sites further suggests that intergenic conserved secondary structures have essential roles in directing gene expression in transcriptional regulation networks.</p

Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair

Correction to Wu DD, Irwin DM, Zhang YP: Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair. BMC Evol Biol 2008, 8:241

Serum 25-hydroxyvitamin D levels and the risk of idiopathic central precocious puberty in girls

Introduction: Prior studies have found inconsistent results regarding the relationship between vitamin D status and Idiopathic Central Precocious Puberty (ICPP). Objective: To assess the role of serum 25-hydroxyvitamin D (25 [OH]D) levels in ICPP development. Method: The authors retrospectively collected data from 221 girls with ICPP and 144 healthy girls between January 2017 and December 2019. The participants’ serum 25(OH)D levels were measured using an automatic chemiluminescence method, and the association between serum 25(OH)D levels and the risk of ICPP was assessed using multivariate logistic regression analysis. Odds Ratios (OR) with 95% Confidence Intervals (95% CI) were calculated as effect estimates. Results: Serum 25(OH)D levels in the ICPP group were significantly lower than those in healthy controls (p &lt; 0.001). Multivariate analysis indicated that girls with insufficient vitamin D levels (OR&nbsp;=&nbsp;0.201; 95% CI 0.094–0.428; p &lt; 0.001) and sufficient vitamin D levels (OR&nbsp;=&nbsp;0.141; 95% CI 0.053–0.375; p &lt; 0.001) both had a lower risk of ICPP than girls with vitamin D deficiency. Moreover, the authors found that the height (p&nbsp;=&nbsp;0.014), weight (p&nbsp;=&nbsp;0.014), breast stage (p&nbsp;=&nbsp;0.010), mother's height (p &lt; 0.001), and luteinizing hormone/follicle-stimulating hormone ratio (p&nbsp;=&nbsp;0.010) in girls with ICPP could be associated with levels of vitamin D. Conclusion: This study found that a low serum 25(OH)D level is an independent risk factor for ICPP, and several characteristics of girls with ICPP could be affected by their vitamin D status.

RD(∗)R_{D^{(\ast)}}, RK(∗)R_{K^{(\ast)}} and neutrino mass in the 2HDM-III with right-handed neutrinos

Given that the two-Higgs-doublet model of type III (2HDM-III) has the potential to address the $R_{D^{(\ast)}}$ anomalies while the resolution to the $R_{K^{(\ast)}}$ deficits requires new degrees of freedom within this framework, we consider in this paper a unified scenario where the low-scale type-I seesaw mechanism is embedded into the 2HDM-III, so as to accommodate the $R_{D^{(\ast)}}$ and $R_{K^{(\ast)}}$ anomalies as well as the neutrino mass. We first revisit the $R_{D^{(\ast)}}$ anomalies and find that the current world-averaged results can be addressed at $2\sigma$ level without violating the bound from the branching ratio $\mathcal{B}(B_c^-\rightarrow \tau^- \bar{\nu})\leqslant 30\%$. The scenario predicts two sub-eV neutrino masses based on a decoupled heavy Majorana neutrino and two nearly degenerate Majorana neutrinos with mass around the electroweak scale. For the $R_{K^{(\ast)}}$ anomalies, the same scenario can generate the required Wilson coefficients in the direction $C_{9 \mu}^{\rm NP}=-C_{10 \mu}^{\rm NP}<0$, with $\mathcal{O}(1)$ Yukawa couplings for the muon and the top quark.Comment: 32 pages, 4 figures; More discussions and references added, final version to be published in JHE