Bis(4-amino­benzene­sulfonato-κN)diaqua­bis(dimethyl­formamide-κO)nickel(II) dihydrate

In the title compound, [Ni(C6H6NO3S)2(C3H7NO)2(H2O)2]·2H2O, the NiII ion (site symmetry ) is coordinated by two –NH2 groups from two 4-amino­benzene­sulfonate anions, two O atoms from two dimethyl­formamide mol­ecules and two water mol­ecules, forming a slightly distorted trans-NiN2O4 octa­hedral geometry. In the crystal structure, inter­molecular O—H⋯O, O—H⋯(O,O) and N—H⋯O hydrogen bonds link the components into a three-dimensional network. The O atoms of the sulfonate group are disordered over two sets of sites in a 0.833 (4):0.167 (4) ratio and the O atom of the uncoordinated water mol­ecule is disordered over two sites in a 0.637 (18):0.363 (18) ratio

Temperature and impurity effects of the polaron in an asymmetric quantum dot

We study the temperature and impurity effects of the ground state energy and the ground state binding energy in an asymmetric quantum dot by using the liner combination operator method. It is found that the ground state energy and the ground state binding energy will increase with increasing the temperature. The ground state ener-gy is a decreasing function of the Coulomb bound potential, whereas the ground state binding energy is an in-creasing one of it

NG2 cells response to axonal alteration in the spinal cord white matter in mice with genetic disruption of neurofilament light subunit expression

<p>Abstract</p> <p>Background</p> <p>Chondroitin sulphate proteoglycan (NG2) expressing cells, morphologically characterized by multi-branched processes and small cell bodies, are the 4^thcommonest cell population of non-neuronal cell type in the central nervous system (CNS). They can interact with nodes of Ranvier, receive synaptic input, generate action potential and respond to some pathological stimuli, but the function of the cells is still unclear. We assumed the NG2 cells may play an active role in neuropathogenesis and aimed to determine if NG2 cells could sense and response to the alterations in the axonal contents caused by disruption of neurofilament light subunit (NFL) expression.</p> <p>Results</p> <p>In the early neuropathological development stage, our study showed that the diameter of axons of upper motor neurons of NFL-/- mice decreased significantly while the thickness of their myelin sheath increased remarkably. Although there was an obvious morphological distortion in axons with occasionally partial demyelination, no obvious changes in expression of myelin proteins was detected. Parallel to these changes in the axons and their myelination, the processes of NG2 cells were disconnected from the nodes of Ranvier and extended further, suggesting that these cells in the spinal cord white matter could sense the alteration in axonal contents caused by disruption of NFL expression before astrocytic and microglial activation.</p> <p>Conclusion</p> <p>The structural configuration determined by the NFL gene may be important for maintenance of normal morphology of myelinated axons. The NG2 cells might serve as an early sensor for the delivery of information from impaired neurons to the local environment.</p

Linezolid and Rifampicin Combination to Combat cfr-Positive Multidrug-Resistant MRSA in Murine Models of Bacteremia and Skin and Skin Structure Infection.

Linezolid resistance mediated by the cfr gene in MRSA represents a global concern. We investigated relevant phenotype differences between cfr-positive and -negative MRSA that contribute to pathogenesis, and the efficacy of linezolid-based combination therapies in murine models of bacteremia and skin and skin structure infection (SSSI). As a group, cfr-positive MRSA exhibited significantly reduced susceptibilities to the host defense peptides tPMPs, human neutrophil peptide-1 (hNP-1), and cathelicidin LL-37 (P &lt; 0.01). In addition, increased binding to fibronectin (FN) and endothelial cells paralleled robust biofilm formation in cfr-positive vs. -negative MRSA. In vitro phenotypes of cfr-positive MRSA translated into poor outcomes of linezolid monotherapy in vivo in murine bacteremia and SSSI models. Importantly, rifampicin showed synergistic activity as a combinatorial partner with linezolid, and the EC50 of linezolid decreased 6-fold in the presence of rifampicin. Furthermore, this combination therapy displayed efficacy against cfr-positive MRSA at clinically relevant doses. Altogether, these data suggest that the use of linezolid in combination with rifampicin poses a viable therapeutic alternative for bacteremia and SSSI caused by cfr-positive multidrug resistant MRSA

Near-threshold photoproduction of J/ψJ/\psi in two-gluon exchange model

The near-threshold photoproduction of $J/\psi$ is regarded as one golden process to unveil the nucleon mass structure, pentaquark state involving the charm quarks, and the poorly constrained gluon distribution of the nucleon at large $x$ ($>0.1$). In this paper, we present an analysis of the current experimental data under a two-gluon exchange model, which shows a good consistency. Using a parameterized function form with three free parameters, we have determined the nucleonic gluon distribution at the $J/\psi$ mass scale. Moreover, we predict the differential cross section of the electroproduction of $J/\psi$ as a function of the invariant mass of the final hadrons $W$, at EicC, as a practical application of the model and the obtained gluon distribution. According to our estimation, thousands of $J/\psi$ events can be detected per year on EicC near the threshold. Therefore, the relevant experimental measurements are suggested to be carried out on EicC.Comment: 6 pages, 7 figure