GWSpace: a multi-mission science data simulator for space-based gravitational wave detection

Space-based gravitational wave detectors such as TianQin, LISA, and TaiJi have the potential to outperform themselves through joint observation. To achieve this, it is desirable to practice joint data analysis in advance on simulated data that encodes the intrinsic correlation among the signals found in different detectors that operate simultaneously. In this paper, we introduce \texttt{GWSpace}, a package that can simulate the joint detection data from TianQin, LISA, and TaiJi. The software is not a groundbreaking work that starts from scratch. Rather, we use as many open-source resources as possible, tailoring them to the needs of simulating the multi-mission science data and putting everything into a ready-to-go and easy-to-use package. We shall describe the main components, the construction, and a few examples of application of the package. A common coordinate system, namely the Solar System Barycenter (SSB) coordinate system, is utilized to calculate spacecraft orbits for all three missions. The paper also provides a brief derivation of the detection process and outlines the general waveform of sources detectable by these detectors.Comment: 24 pages, 13 figures, GWSpace will be uploaded at https://github.com/TianQinSYSU/GWSpac

Ethambutol optic neuropathy

Ethambutol(EMB)has been used as first-line antibiotics to treat tuberculosis. Side effects of ethambutol have been well documented since its original use, with the most serious one being optic neuropathy. EMB-induced optic neuropathy(EON)may be reversible in the early stages, but delayed diagnosis has been shown to result in permanent visual loss. Thus the reversibility of EON is dependent on early detection. In this review, we discuss risk factors, detection methods, treatment and prevention of EON

ASS1 gene mutation in a neonate with citrullinemia type Ⅰ

Objective To detect blood acylcarnitine and genes in a newborn with suspected citrullinemia, and to detect gene mutations in their parents, so as to clarify their diagnosis and follow-up investigations. Methods Genetic metabolic diseases were screened in the newborn baby using tandem mass spectrometry. Peripheral blood samples were collected from the newborn patient with suspected citrullinemia to detect the products of genetic metabolic diseases. Peripheral blood samples were collected from newborns and their parents for high-throughput sequencing and Sanger sequencing. The blood samples of the newborns and their parents were sequenced and verified, and then the genetic abnormalities were analyzed. Results Tandem mass spectrometry showed that the level of citrulline increased(1 043 μmol/L), the level of citrulline increased to 2 072 μmol/L after recall immediately. Double heterozygous mutations of ASS1 gene in the proband were identified:c.256C＞T and c.577G＞A,which were confirmed in the parents.The case was diagnosed with citrullinemia type Ⅰ. Conclusions Neonatal tandem mass spectrometry, in combination with a pedigree analysis of the gene sequencing, may support the diagnosis of citrullinemia

Microstructure and Properties of High Current Pulsed Electron Beam Surface Alloying on 20 Steel

To improve the surface properties of 20 steel, the chromium element was alloyed on 20 steel by high current pulsed electron beam (HCPEB) with pre-coating to obtain a high quality of alloyed layers.Microstructure and properties of the alloying layer were studied by means of XRD, OM, SEM, TEM and multi-purpose microcomputer electrochemistry analyzer. The results show that, after HCPEB alloying, the formation of an alloyed layer with the depth of about 4-6μm on the surface is observed. The solid solution and diffusion of Cr element occurs on the surface of the substrate.Bending and granulating occur on part of cementite under bending stress induced by HCPEB irradiation, the C atoms generated by the dissolution of the cementite combine with the chromium to form a small amount of nanograined carbide Cr23C6. After HCPEB alloying, the surface microhardness increases by 35% and corrosion current density reduces one order of magnitude than original sample

Construction and analysis of a plant non-specific lipid transfer protein database (nsLTPDB)

<p>Abstract</p> <p>Background</p> <p>Plant non-specific lipid transfer proteins (nsLTPs) are small and basic proteins. Recently, nsLTPs have been reported involved in many physiological functions such as mediating phospholipid transfer, participating in plant defence activity against bacterial and fungal pathogens, and enhancing cell wall extension in tobacco. However, the lipid transfer mechanism of nsLTPs is still unclear, and comprehensive information of nsLTPs is difficult to obtain.</p> <p>Methods</p> <p>In this study, we identified 595 nsLTPs from 121 different species and constructed an nsLTPs database -- nsLTPDB -- which comprises the sequence information, structures, relevant literatures, and biological data of all plant nsLTPs <url>http://nsltpdb.life.nthu.edu.tw/</url>.</p> <p>Results</p> <p>Meanwhile, bioinformatics and statistics methods were implemented to develop a classification method for nsLTPs based on the patterns of the eight highly-conserved cysteine residues, and to suggest strict Prosite-styled patterns for Type I and Type II nsLTPs. The pattern of Type I is C X₂V X_5-7C [V, L, I] × Y [L, A, V] X_8-13CC × G X₁₂D × [Q, K, R] X₂CXC X_16-21P X₂C X_13-15C, and that of Type II is C X₄L X₂C X_9-11P [S, T] X₂CC X₅Q X_2-4C[L, F]C X₂[A, L, I] × [D, N] P X_10-12[K, R] X_4-5C X_3-4P X_0-2C. Moreover, we referred the Prosite-styled patterns to the experimental mutagenesis data that previously established by our group, and found that the residues with higher conservation played an important role in the structural stability or lipid binding ability of nsLTPs.</p> <p>Conclusions</p> <p>Taken together, this research has suggested potential residues that might be essential to modulate the structural and functional properties of plant nsLTPs. Finally, we proposed some biologically important sites of the nsLTPs, which are described by using a new Prosite-styled pattern that we defined.</p

CEPC Conceptual Design Report: Volume 2 - Physics & Detector

The Circular Electron Positron Collider (CEPC) is a large international scientific facility proposed by the Chinese particle physics community to explore the Higgs boson and provide critical tests of the underlying fundamental physics principles of the Standard Model that might reveal new physics. The CEPC, to be hosted in China in a circular underground tunnel of approximately 100 km in circumference, is designed to operate as a Higgs factory producing electron-positron collisions with a center-of-mass energy of 240 GeV. The collider will also operate at around 91.2 GeV, as a Z factory, and at the WW production threshold (around 160 GeV). The CEPC will produce close to one trillion Z bosons, 100 million W bosons and over one million Higgs bosons. The vast amount of bottom quarks, charm quarks and tau-leptons produced in the decays of the Z bosons also makes the CEPC an effective B-factory and tau-charm factory. The CEPC will have two interaction points where two large detectors will be located. This document is the second volume of the CEPC Conceptual Design Report (CDR). It presents the physics case for the CEPC, describes conceptual designs of possible detectors and their technological options, highlights the expected detector and physics performance, and discusses future plans for detector R&D and physics investigations. The final CEPC detectors will be proposed and built by international collaborations but they are likely to be composed of the detector technologies included in the conceptual designs described in this document. A separate volume, Volume I, recently released, describes the design of the CEPC accelerator complex, its associated civil engineering, and strategic alternative scenarios

CEPC Conceptual Design Report: Volume 2 - Physics & Detector

The Circular Electron Positron Collider (CEPC) is a large international scientific facility proposed by the Chinese particle physics community to explore the Higgs boson and provide critical tests of the underlying fundamental physics principles of the Standard Model that might reveal new physics. The CEPC, to be hosted in China in a circular underground tunnel of approximately 100 km in circumference, is designed to operate as a Higgs factory producing electron-positron collisions with a center-of-mass energy of 240 GeV. The collider will also operate at around 91.2 GeV, as a Z factory, and at the WW production threshold (around 160 GeV). The CEPC will produce close to one trillion Z bosons, 100 million W bosons and over one million Higgs bosons. The vast amount of bottom quarks, charm quarks and tau-leptons produced in the decays of the Z bosons also makes the CEPC an effective B-factory and tau-charm factory. The CEPC will have two interaction points where two large detectors will be located. This document is the second volume of the CEPC Conceptual Design Report (CDR). It presents the physics case for the CEPC, describes conceptual designs of possible detectors and their technological options, highlights the expected detector and physics performance, and discusses future plans for detector R&D and physics investigations. The final CEPC detectors will be proposed and built by international collaborations but they are likely to be composed of the detector technologies included in the conceptual designs described in this document. A separate volume, Volume I, recently released, describes the design of the CEPC accelerator complex, its associated civil engineering, and strategic alternative scenarios

CEPC Conceptual Design Report: Volume 2 - Physics & Detector

The Circular Electron Positron Collider (CEPC) is a large international scientific facility proposed by the Chinese particle physics community to explore the Higgs boson and provide critical tests of the underlying fundamental physics principles of the Standard Model that might reveal new physics. The CEPC, to be hosted in China in a circular underground tunnel of approximately 100 km in circumference, is designed to operate as a Higgs factory producing electron-positron collisions with a center-of-mass energy of 240 GeV. The collider will also operate at around 91.2 GeV, as a Z factory, and at the WW production threshold (around 160 GeV). The CEPC will produce close to one trillion Z bosons, 100 million W bosons and over one million Higgs bosons. The vast amount of bottom quarks, charm quarks and tau-leptons produced in the decays of the Z bosons also makes the CEPC an effective B-factory and tau-charm factory. The CEPC will have two interaction points where two large detectors will be located. This document is the second volume of the CEPC Conceptual Design Report (CDR). It presents the physics case for the CEPC, describes conceptual designs of possible detectors and their technological options, highlights the expected detector and physics performance, and discusses future plans for detector R&D and physics investigations. The final CEPC detectors will be proposed and built by international collaborations but they are likely to be composed of the detector technologies included in the conceptual designs described in this document. A separate volume, Volume I, recently released, describes the design of the CEPC accelerator complex, its associated civil engineering, and strategic alternative scenarios