小児と成人の前房隅角構造の比較

広島大学(Hiroshima University)博士(医学)Doctor of Philosophy in Medical Sciencedoctora

Output-Based Error Estimation and Model Reduction for Chaotic Flows

Turbulent flows are characterized by chaotic variations in state variables and are commonly found in many applications such as jet engine mixing and flow over bluff bodies. Large Eddy Simulations (LES) of these chaotic flows have already proven to be useful to the design process. However, LES is resource and time-intensive. Application of output-based methods for error estimation and mesh adaptation would decrease the cost of these chaotic simulations while still retaining their overall accuracy. However, a direct application of unsteady adjoint-based methods is not possible due to the flows’ inherent sensitivity to the initial conditions and the exponential growth of the corresponding adjoint solutions. This dissertation proposes the Hyper-Reduced Order Modeling-Least Squares Shadowing (HROM-LSS) method, which combines model reduction principles with adjoint sensitivity techniques for chaotic flows to calculate accurate adjoints that are cheaper to solve for than the Least Squares Shadowing (LSS) method on its own. All primal solutions are solved using the discontinuous Galerkin finite element method. Results of the HROM-LSS method for the Kuramoto-Sivashinsky equation and the NACA 0012 airfoil at high Reynolds numbers show promise for this combined method and have been shown to outperform the LSS method when calculating the effect of the discretization errors on the output. In particular, the average CPU times for the HROM-LSS method are reduced by as much as 97.44% for short time simulations and as much as 64% for longer simulations, making the HROM-LSS method a more practical option to calculate adjoint for chaotic flows in order to perform output-based error estimation for turbulent flows.PHDAerospace EngineeringUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttps://deepblue.lib.umich.edu/bitstream/2027.42/149954/1/ykmizu_1.pd

Discrete plane segmentation and estimation from a point cloud using local geometric patterns

International audienceThis paper presents a method for segmenting a 3D point cloud into planar surfaces using recently obtained discrete geometry results. In discrete geometry, a discrete plane is defined as a set of grid points lying between two parallel planes with a small distance, called thickness. Contrarily to the continuous case, there exist a finite number of local geometric patterns (LGPs) appearing on discrete planes. Moreover, such a LGP does not possess the unique normal vector but a set of normal vectors. By using those LGP properties, we first reject non-linear points from a point cloud, and then classify non-rejected points whose LGPs can have common normal vectors into a planar-surface-point set. From each segmented point set, we also estimate parameters of a discrete plane by minimizing its thickness

Changing Pattern of Deiminated Proteins in Developing Human Epidermis

Peptidylarginine deiminases are widely distributed, calcium-ion-dependent enzymes that convert arginine residues of proteins into citrulline residues. This reaction, deimination, is thought to be an important event during the final stage of epidermal differentiation, possibly associated with integration and disintegration of keratin filaments. To elucidate the possible roles of protein deimination during human epidermal development we investigated localization of deiminated proteins using anti-citrulline peptide antibody, which preferentially recognizes citrulline residues in the V subdomains of keratin 1, and anti-chemically modified citrulline antibody, which enables detection of citrulline residues independent of amino acid sequences. Anti-chemically modified citrulline antibody, but not anti-citrulline peptide antibody stained the periderm in two-layered epidermis of 49 d and 57 d estimated gestational age. In the stratified epidermis of 88 d, 96 d, and 108 d estimated gestational age fetal skin, anti-citrulline peptide antibody and anti-chemically modified citrulline antibody staining was seen in the periderm and intermediate cell layers. After periderm cells regressed and keratinization began in the interfollicular epidermis, anti-citrulline peptide antibody and anti-chemically modified citrulline antibody were restricted to the cornified cell layers of the interfollicular epidermis, similar to the distribution patterns of that in adult epidermis. Postembedding immunoelectron microscopy showed anti-citrulline peptide antibody immunogold labeling over the cytoplasmic intermediate filament network in the periderm and the intermediate cell layers. These results demonstrate an orderly formation of deiminated proteins in different layers of embryonic epidermis and suggest important roles for peptidylarginine deiminases in human epidermal morphogenesis

ヘドニック・モデルによる札幌CBDオフィス賃貸市場の構造分析(1985～2000年度)

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品質調整済新規募集オフィス賃料指数の推定-札幌CBD(1985-2000年度)における実証研究-

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Genetic Factors Associated with Heading Responses Revealed by Field Evaluation of 274 Barley Accessions for 20 Seasons

Heading time is a key trait in cereals affecting the maturation period for optimal grain filling before harvest. Here, we aimed to understand the factors controlling heading time in barley (Hordeum vulgare). We characterized a set of 274 barley accessions collected worldwide by planting them for 20 seasons under different environmental conditions at the same location in Kurashiki, Japan. We examined interactions among accessions, known genetic factors, and an environmental factor to determine the factors controlling heading response. Locally adapted accessions have been selected for genetic factors that stabilize heading responses appropriate for barley cultivation, and these accessions show stable heading responses even under varying environmental conditions. We identified vernalization requirement and PPD-H1 haplotype as major stabilizing mechanisms of the heading response for regional adaptation in Kurashiki