Reward learning as a potential target for pharmacological augmentation of cognitive remediation for schizophrenia: a roadmap for preclinical development.

RationaleImpaired cognitive abilities are a key characteristic of schizophrenia. Although currently approved pharmacological treatments have demonstrated efficacy for positive symptoms, to date no pharmacological treatments successfully reverse cognitive dysfunction in these patients. Cognitively-based interventions such as cognitive remediation (CR) and other psychosocial interventions however, may improve some of the cognitive and functional deficits of schizophrenia. Given that these treatments are time-consuming and labor-intensive, maximizing their effectiveness is a priority. Augmenting psychosocial interventions with pharmacological treatments may be a viable strategy for reducing the impact of cognitive deficits in patients with schizophrenia.ObjectiveWe propose a strategy to develop pharmacological treatments that can enhance the reward-related learning processes underlying successful skill-learning in psychosocial interventions. Specifically, we review clinical and preclinical evidence and paradigms that can be utilized to develop these pharmacological augmentation strategies. Prototypes for this approach include dopamine D1 receptor and α7 nicotinic acetylcholine receptor agonists as attractive targets to specifically enhance reward-related learning during CR.ConclusionThe approach outlined here could be used broadly to develop pharmacological augmentation strategies across a number of cognitive domains underlying successful psychosocial treatment

Planetary isophotes as a clue to aerosol characteristics

A study was conducted to see how much information could be extracted from the Mariner 9 Mars isophotes taken at a phase angle of approximately 60 deg. It was found that the Minnaert functions and both isotropic and Rayleigh scattering could easily be ruled out, and that it was essential to use forward-peaked phase functions, which were computed from Mie theory. Isophotes similar to those observed assuming a semi-infinite dust cloud with a considerable variation in particle properties and size distribution could be obtained, so long as the ratio of the multiply- to singly-scattered light was held within certain limits. These conditions are met by micron-sized, moderatly absorbing mineral grains whose mean size should not be much larger than a micron. It was also found that a dust cloud of finite optical thickness bounded from below by a Lambert ground would fit the isophote data

Applications Technology Satellite /ATS-1/ Suprathermal Ion Detector experiment /SID/ data reduction and analysis Final report, 6 Dec. 1966 - 30 Mar. 1970

Data analysis on ATS-1 Suprathermal Ion Detector /SID/ measurements of low energy plasma flow in magnetopause boundar

Results from tests, with van-mounted sensor, of magnetic leader cable for aircraft guidance during roll-out and turnoff

Tests were conducted with a van mounted experimental magnetic leader cable sensor to evaluate its potential for measuring aircraft displacement and heading with respect to the leader cable during roll out and turnoff. Test results show that the system may be usable in measuring displacement but the heading measurement contains errors introduced by distortion of the magnetic field by the metal van or aircraft

A Data Exchange Standard for Optical (Visible/IR) Interferometry

This paper describes the OI Exchange Format, a standard for exchanging calibrated data from optical (visible/infrared) stellar interferometers. The standard is based on the Flexible Image Transport System (FITS), and supports storage of the optical interferometric observables including squared visibility and closure phase -- data products not included in radio interferometry standards such as UV-FITS. The format has already gained the support of most currently-operating optical interferometer projects, including COAST, NPOI, IOTA, CHARA, VLTI, PTI, and the Keck Interferometer, and is endorsed by the IAU Working Group on Optical Interferometry. Software is available for reading, writing and merging OI Exchange Format files.Comment: 26 pages, 1 figur

Laser velocimeter systems analysis applied to a flow survey above a stalled wing

A laser velocimeter operating in the backscatter mode was used to survey the flow above a stalled wing. Polarization was used to separate the two orthogonal velocity components of the fringe-type laser velocimeter, and digital counters were used for data processing. The velocities of the kerosene seed particles were measured with less than 2 percent uncertainty. The particle velocity measurements were collected into histograms. The flow field survey was carried out above an aspect-ratio-8 stalled wing with an NACA 0012 section. The angle of attack was 19.5 deg, the Mach number was 0.49, and the Reynolds number was 1,400,000. The flow field was characterized by the periodic shedding of discrete vortices from near the crest of the airfoil

Weight, volume, and center of mass of segments of the human body

Weight, volume, and center of mass of segments of human bod