Synthesis of some new quinoxalines bearing pyridinyl thiazole moiety

ABSTRACT. Keeping the objective to build up a new structural class of quinoxaline, a new series of quinoxaline derivatives bearing the pyridinyl thiazole nucleus have been synthesized by basecatalyzed chloro-amine condensation reaction approach. The protocol offers expeditious and easy synthesis with excellent yield. The chemical structures of the synthesized compounds were elucidated by 1 H NMR, 13 C NMR, FT-IR, elemental analysis, and mass spectral data

Synthesis and characterization of novel pyrimidine derivatives of N-pentyl-2,7-diphenyl-3,8a-dihydroimidazo[1,2-a]pyrimidin-3-amine via 4-phenylpyrimidin-2-amine

The target compound N-pentyl-2,7-diphenyl-3,8a-dihydroimidazo[1,2-a]pyrimidin-3-amine have been synthesized by4-phenylpyrimidin-2-amine with Triflouro acetic acid and benzyldehyde. The obtained products were characterized by 1H NMR, Mass and IR Spectra. Purity of all the compounds has been checked on thin layer chromatographic plate and NMR analysis technique

Fuller’s earth catalyzed rapid synthesis of bis (indolyl) methanes under solvent free condition

A rapid and highly efficient synthesis of various bis(indolyl)methanes with high yield by the reaction of indoles 1a-c and arylaldehydes 2a'-m' in presence of fuller’s earth is demonstrated. This simple and versatile protocol is found to be an efficient catalyst for the electrophilic addition reaction of indole and works well under solvent free condition as well as in aqueous medium. The structure of newly synthesized compound 3m has been confirmed by single crystal X-ray crystallography

<span style="font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Fuller’s earth catalyzed rapid synthesis of bis(indolyl)methanes under solvent free condition</span>

1032-1038<span style="font-size:12.0pt;font-family: " times="" new="" roman";mso-fareast-font-family:"times="" roman";mso-ansi-language:="" en-gb;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="" lang="EN-GB">A rapid and highly efficient synthesis of various bis(indolyl)methanes with high yield by the reaction of indoles 1a-c and arylaldehydes 2a'-m' in presence of fuller’s earth is demonstrated. This simple and versatile protocol is found to be an efficient catalyst for the electrophilic addition reaction of indole and works well under solvent free condition as well as in aqueous medium. The structure of newly synthesized compound 3m has been confirmed by single crystal X-ray crystallography.</span