Magnesium Sulfate Has Potential Scavenging Effects on Cyclophosphamide-Induced Ovarian Damage in A Rat Model

Objective: This study proposed to investigate whether magnesium sulfate (MgSO4)could reduce the ovarian damage induced by cyclophosphamide (Cyc). Material and Methods:Thirty female rats were used for this study: Control group (n10)- Only laparotomy; Cyc groupn10)-75 mg/kg Cyc intraperitoneally; and CycMgSO4 group (n10)-75 mg/kg Cyc on day 0 and200 mg/kg MgSO4 on days 1-7 (both intraperitoneally). The extent of histopathological damage andthe number of ovarian follicles were determined. The levels of anti-Mullerian hormone (AMH)were measured in blood samples. Results: Statistically significant differences in the AMH valueswere observed in the control group versus Cyc group and Cyc group versus CycMgSO4 group(p0.05). The levels of AMH were the least in the Cyc group. The total tissue damage in the Cycgroup was significantly higher than that in the control, as well as in the CycMgSO4 group(p0.05). The follicle counts were the least in the Cyc group. Conclusion: Cyc caused ovarian damage and reduced the ovarian reserves. The ovarian reserves in the MgSO4-treated group were better than those in the other groups, and there was least ovarian damage in the MgSO4-treated group

Huge Hydro-Pyosalpinx in a Recently Sexually Active Woman

Pelvik inflamatuvar hastalık, endometrit, parametrit, ooforit, tubo-ovaryan abse ve/veya peritoniti kapsayan üst genital yollarının inflamasyonu olarak tanımlanır. Pelvik inflamatuar hastalık çoğunlukla alt genital trakttan asendan yolla gelen enfeksiyonlardan kaynaklanır. Reproduktif çağda olan ve rahim içi araç kullanan kadınlar pelvik inflamatuvar hastalık açısından yüksek risk taşırlar. Bu çalışmada yeni seksüel aktif genç kadında dev hidrosalpenks olgusu sunuldu. Yeni seksüel aktif (4 ay), 23 yaşında kadın hasta jinekoloji polikliniğimize karın ağrısı, ateş ve halsizlik şikâyetleri ile başvurdu. Ateşi 38.7 oC olarak ölçüldü. Jinekolojik muayenede eksternal genital organlar normal, serviks nullipar görünümde idi ve gri-kahverengi kokulu akıntı izlendi. Transvajinal ultrasonografide sağ adneksiyel alanda 91x29 mm boyutunda hidrosalpenks görünümü izlendi. Hasta hastaneye yatırılarak 14 gün süre ile parenteral geniş spektrumlu antibiyotik tedavisi verildi. Taburculuk sonrası oral antibiyotik tedavisine devam edildi. Oral antibiyotik tedavisinin 2. hafta ve 1. ay kontrollerinde hidrosalpenks görünümü sırası ile 48x9 mm ve 30x8 mm boyutlarına geriledi. Reproduktif çağdaki kadınları etkileyen pelvik inflamatuvar hastalık seksüel aktivitenin başlamasından kısa bir süre sonra ortaya çıkabilir ve erken dönemde ciddi komplikasyonlara sebep olabilir. Bu nedenle seksüel aktivitesi yeni başlamış genç yaş kadınların seksüel geçişli hastalıklar hakkında bilgilendirilmesi gereklidir.Pelvic inflammatory disease is defined as the inflammation of the upper genital tract. Its spectrum includes endometritis, parametritis, oophoritis, tubo-ovarian abscess and sometimes even peritonitis. Pelvic inflammatory disease is most often caused by infection from the subgenital tract. Reproductive women with intrauterine devices are at high risk for pelvic inflammatory disease. In this study, we presented a giant hydrosalpinx in a newly sexually active young woman. A 23-years old woman with new-onset sexual intercourse (4 months), admitted to our gynecology out-patient clinic with complaints of abdominal pain, fever and fatique. She was suffering from pelvic pain and aberrant vaginal discharge for two days. Her body temperature was 38.7oC. Her gynecological examination findings were as follows: normal external genitalia, nulliparous external os with green-brown and heavy discharge. Evaluation with transvaginal ultrasonography showed 91x29mm hydro-pyosalpinx on the right adnex. Parenteral broad-spectrum antibiotic was given for 14 days. The patient was discharged with oral antibiotherapy. At two weeks and one month controls after cessation of oral antibiotherapy, the size of hydrosalpinx decreased to 48x9 mm and 30x8 mm respectively. Pelvic inflammatory disease affecting reproductive age women may develop shortly after the onset of sexual activity and may cause serious complications in the early period. For this reason, younger women who have newly started sexual activity need to be informed about sexually transmitted diseases

Success of Systemic Methotrexate Administration Versus Laparoscopic Salpingostomy in Ectopic Pregnancy

OBJECTIVE: In this study, we tried to compare the efficacies of laparoscopic salpingostomy and medication with a single dose of Methotrexate (50mg/m2) in ectopic pregnancy to determine the differences between the two methods in terms of treatment outcomes. STUDY DESIGN: In this study, 64 patients with ectopic pregnancy who had been administered an MTX therapy between August 2007 and July 2010 (Group A) were compared with another 64 patients with matching ages who had undergone a laparoscopic salpingostomy (Group B). The two groups were compared in terms of age, gravida, parity, initial hCG value, hCG measured at the time of being discharged from the hospital, hCG values checked a week later and the number of hospitalization days. The number of repeating doses and the rate of undergoing a laparoscopy salpingostomy were calculated in patients receiving MTX. RESULTS: The hCG values of the patients in the MTX and laparoscopy groups respectively were as follows: Initial hCG measurement; 670.5±1027.5 vs. 5511.3± 7293.0 (p=0.0001), hCG measured at the time of discharge; 352.3±627.0 vs. 869.7±599.1 (p=0.016), and hCG value after a week; 292.5±617.4 vs 864.1±1531.8 (p=0.023). The difference in the number of hospitalization days between the two groups came out to be significant; 2.4±4.2 for the MTX group and 1.3±1.6 for the laparoscopy group with p=0.01. Repetition of the dose became necessary in 14.1% (9/64) of the patients receiving medical treatment (MTX) as their hCG values did not decrease. Success was achieved in treating 4.7% (6/64) of these patients after the second dose and the rate of undergoing a laparoscopic salpingostomy due to MTX failure was calculated to be 4.6%. CONCLUSION: We found in this study that MTX used as a medical treatment in ectopic pregnancy was as successful as a laparoscopic salpingostomy. MTX failure can be minimized by firmly determining the criteria for the patients who will be given a medical treatment