Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide

Autophagy plays important roles in many biological processes, but our understanding of the mechanisms regulating stem cells by autophagy is limited. Interpretations of earlier studies of autophagy using knockouts of single genes are confounded by accumulating evidence for other functions of many autophagy genes. Here, we show that, in contrast to Fip200 deletion, inhibition of autophagy by deletion of Atg5, Atg16L1, or Atg7 does not impair the maintenance and differentiation of postnatal neural stem cells (NSCs). Only Fip200 deletion, but not Atg5, Atg16L1, or Atg7 deletion, caused p62/sequestome1 aggregates to accumulate in NSCs. Fip200 and p62 double conditional knockout mice demonstrated that p62 aggregate formation triggers aberrant superoxide increases by impairing superoxide dismutase functions. By comparing the inhibition of autophagy by deletion of Atg5, Atg16L1, or Atg7 with Fip200 deletion, we revealed a critical role of increased p62 in determining the fate of autophagy-deficient NSCs through intracellular superoxide control

Labour and Community, Past and Future: or why Merrie (White, Male) England and Mateship are not enough

You would think New Labour had invented the word \u27Community\u27, so often do the B1airites use it. A new\u27 Active Community Unit\u27 is being established in Whitehall, to spearhead Blair\u27s challenge \u27for Britain to mark the millennium with an explosion of giving of acts of community that would touch people\u27s lives\u27l. Key Labour politicians have attended seminars on communitarianism, a rather authoritarian moralistic voluntarism, developed by sociologist Amitrai Etzioni in the USA

Introduction to Mary Wollstonecraft and 200 years of feminism

To mark the 200th anniversary of Mary Wollstonecraft's death, this book brings together contributions which cover interdisciplinary readings of Wollstonecraft's texts as well as historical explorations of the politics of gender, and reflect a convergence of feminist theory and practice. The book's themes include the roles of imagination, reason, and romance in sexual politics; the problems of forming feminist identities; the tensions between ideas of equality or common humanity; and differences of sex, class, and race power

The contest for social science: relations and representations of gender and class

Opening in the period of revolutions between 1789 and 1850, this book explores the contention over social science from above and below. It breaks away from othodox interpretations of the development of social science to explore the subject as a contest for class and gender power. The author gives a picture of the experiences which made men and women passionate about the social science project, and explores how different groups aimed at self-liberation, or power over others. She details the contribution made by working-class people and by women to the social science story, and shows how language and metaphor were used to construct social identities. This account of the production of knowledge as a contestable process, in its historical perspective, constructs a new politics of knowledge. The book may be important to those interested in social and cultural history, the history of natural and social science, gender and women's studies, social policy, social work and social action