PENGEMBANGAN BAHAN AJAR BIPA BERBASIS KOMUNIKASI BISNIS LINTAS BUDAYA DENGAN PENDEKATAN KONTEKSTUAL

Seiring dengan perkembangan inovasi teknologi, fenomena globalisasi lebih signifikan, hubungan antara negara lebih lama lebih erat. Indonesia sebagai negara berkembang dengan pesat yang berperan penting dalam bidang ekonomi di dunia dan pasti akan bekerja sama dengan negara lain untuk mempromosikan pengembangan. Sementara ini, Tiongkok telah mengusulkan Inisiatif Sabuk dan Jalan untuk mempromosikan pembangunan ekonomi dan budaya dengan negara-negara tetangga, yaitu: The Silk Road Economic Belt and the 21st-century Maritime Silk Road. Maka Tiongkok-Indonesia memperkuat kerja sama bukan hanya di bidang ekonomi, tetapi juga di bidang budaya. Bahasa menjadi salah satu alat berkomunikasi yang sangat penting dalam proses bisnis maupun proses pembelajaran. Pembelajaran bahasa Indonesia bagi penutur asing tidak lepas dari komponen bahan ajar. Bahan ajar sebagai alat penting untuk menjelaskan dan mentransformasi pengetahuan. Bahan ajar yang digunakan dalam pembelajaran harus sesuai dengan kebutuhan. Menurut data yang dikumpulkan bahwa kebutuhan bahan ajar bagi mahasiswa Tiongkok jurusan bahasa Indonesia yaitu membutuhkan bahan ajar bahasa Indonesia yang khusus di konteks komunikasi bisnis lintas budaya. Gegar budaya dalam bidang kerja merupakan tantangan pokok bagi mahasiswa yang lulus dari jurusan bahasa Indonesia. Ilmu pengetahuan ekonomi atau bisnis merupakan hal yang sangat penting dan sangat dibutuhkan untuk mengombinasi kompetensi komunikasi lintas budaya. jadi, untuk memenuhi kebutuhan mahasiswa Tiongkok, bahan ajar yang dikembangkan ini berbentuk modul dengna pendekatan kontekstual dan konten isinya meliputi pengetahuan ekonomi, budaya dan kosa kata yang terkait di berbagai bidang. Jenis pekerjaan yang dipilih dalam bahan ajar ini merupakan pekerjaan yang sesuai dengan perkembangan sosial. Sehingga yang dipelajari dari bahan ajar ini dapat digunakan di kehidupan nyata oleh mahasiswa Tiongkok yang lulus dari jurusan bahasa Indonesia. Along with the development of technological innovation, the phenomenon of globalization is more significant, the relationship between countries is longer. Indonesia as a rapidly developing country plays an important role in the economic sector in the world and will definitely cooperate with other countries to promote development. Meanwhile, China has proposed a Belt and Road Initiative to promote economic and cultural development with neighboring countries, namely: The Silk Road Economic Belt and the 21st-century Maritime Silk Road. So China-Indonesia strengthens cooperation not only in the economic field, but also in the cultural field. Language is one of the most important communication tools in business processes and in the learning process. Learning Indonesian for foreign speakers cannot be separated from the components of teaching materials. Teaching materials as an important tool for explaining and transforming knowledge. Teaching materials used in learning must be in accordance with the needs. According to the data collected, the need for teaching materials for Chinese students majoring in Indonesian is requiring Indonesian language teaching materials specifically in the context of cross-cultural business communication. Cultural shock in the work field is a major challenge for students graduating from the Indonesian language department. Economics or business science is very important and very necessary to combine cross-cultural communication competences. So, to meet the needs of Chinese students, the teaching materials developed are in the form of modules with a contextual approach and the content includes economic knowledge, culture and related vocabulary in various fields. The type of work chosen in this teaching material is a job that is in accordance with social development. So that what is learned from this teaching material can be used in real life by Chinese students who graduate from the Indonesian language department

Electron-induced non-monotonic pressure dependence of the lattice thermal conductivity of {\theta}-TaN

Recent theoretical and experimental research suggests that $\theta$-TaN is a semimetal with high thermal conductivity ($\kappa$), primarily due to the contribution of phonons ($\kappa_\texttt{ph}$). By using first-principles calculations, we show a non-monotonic pressure-dependence of the $\kappa$ of $\theta$-TaN. $\kappa_\texttt{ph}$ first increases until it reaches a maximum at around 60 GPa, and then decreases. This anomalous behaviour is a consequence of the competing pressure responses of phonon-phonon and phonon-electron interactions, in contrast to the other known materials BAs and BP, where the non-monotonic pressure dependence is caused by the interplay between different phonon-phonon scattering channels. Although TaN has similar phonon dispersion features to BAs at ambient pressure, its response to pressure is different and an overall stiffening of the phonon branches takes place. Consequently, the relevant phonon-phonon scattering weakens as pressure increases. However, the increased electronic density of states around the Fermi level significantly enhances phonon-electron scattering at high pressures, driving a decrease in $\kappa_{\mathrm{ph}}$. At intermediate pressures ($\sim$20$-$70 GPa), the $\kappa$ of TaN surpasses that of BAs. Our work provides deeper insight into phonon transport in semimetals and metals where phonon-electron scattering is relevant.Comment: 5 pages, 4 figure

Progress on Optical Fiber Biochemical Sensors Based on Graphene

Graphene, a novel form of the hexagonal honeycomb two-dimensional carbon-based structural material with a zero-band gap and ultra-high specific surface area, has unique optoelectronic capabilities, promising a suitable basis for its application in the field of optical fiber sensing. Graphene optical fiber sensing has also been a hotspot in cross-research in biology, materials, medicine, and micro-nano devices in recent years, owing to prospective benefits, such as high sensitivity, small size, and strong anti-electromagnetic interference capability and so on. Here, the progress of optical fiber biochemical sensors based on graphene is reviewed. The fabrication of graphene materials and the sensing mechanism of the graphene-based optical fiber sensor are described. The typical research works of graphene-based optical fiber biochemical sensor, such as long-period fiber grating, Bragg fiber grating, no-core fiber and photonic crystal fiber are introduced, respectively. Finally, prospects for graphene-based optical fiber biochemical sensing technology will also be covered, which will provide an important reference for the development of graphene-based optical fiber biochemical sensors

Risk and prognosis of second cutaneous melanoma after radiotherapy for breast cancer: A population-based analysis

Radiation therapy (RT), a primary treatment for breast cancer (BC), may be associated with increased non-BC tumor risk. We aimed to examine second cutaneous melanoma (SCM) risk in BC patients who underwent RT and to assess their survival outcomes. Data from 520,977 BC patients diagnosed between 1973–2018 were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Cumulative SCM incidence was estimated using the Fine–Gray competing risk model. Poisson regression analysis was conducted to calculate the standardized incidence ratio (SIR) and estimate the SCM relative risk in patients who underwent RT compared to those who did not. Overall survival (OS) and cancer-specific survival (CSS) were assessed using the Kaplan‒Meier method. Among the 520,977 BC patients, 243,676 (46.8%) underwent surgery and RT, while 277,301 (53.2%) only underwent surgery. Our results suggest that BC patients receiving RT had a higher SCM risk than those who did not (hazard ratio [HR] 1.40; 95% confidence interval [CI] 1.30-1.51; P < 0.001). SCM incidence was also higher in BC patients treated with RT than in the general US population (SIR 1.12; 95% CI 1.05-1.19; P < 0.05). However, SCM patients who received RT had a significantly higher 10-year survival rate than those who did not receive RT (14.90% vs 5.94%; P < 0.001). No significant difference was found in 10-year OS or 5-year CSS between SCM following RT and only primary cutaneous melanoma (OPCM), but SCM patients who did not receive RT had a significantly lower 10-year OS, with no significant difference in CSS. This study suggests an increased SCM likelihood in BC patients due to RT, although the overall risk is minimal

Enzyme Kinetics Studies of Nucleoside Diphosphate Kinase in Human Erythrocytes and Frequency Distribution in Healthy Subjects and Transplant Recipients in Chinese Han Population

ABSTRACT Nucleoside diphosphate kinase (NDPK), as a house-keeping protein, involves in various molecular processes including signal transduction, energy and drug metabolism. The main objective was to investigate NDPK kinetics in human erythrocytes and to monitor the frequency distribution of NDPK activity levels in Chinese healthy subjects and transplant recipients. METHODS: NDPK activity in erythrocytes was detected by a validated ion-pair high-performance liquid chromatogram method. NDPK kinetics studies were carried out systematically. NDPK activity levels were determined in 500 healthy subjects, 250 kidney and 250 liver transplant recipients in Chinese Han population. RESULTS: Thermal and pH stability studies indicated NDPK was relatively stable at temperature 30-45ºC and pH 6.0-9.0. In substrate dependency study, the apparent Michaelis-Menten constant (K m ) and maximum velocity of enzymatic reaction (V max ) increased with concentration of substrates. Meanwhile, in product inhibition study, with the increasing concentration of dATP, the V max of dADP decreased with constant K m and K m of dGTP increased with constant V max . NDPK activity levels revealed a 7-fold variability and were not normally distributed in all groups. NDPK activity levels were significantly (P&lt;0.05) higher in transplant group than those in health group. Additionally, much higher NDPK activity levels had been shown (P&lt;0.001) in liver transplant recipients when compared to kidney transplant cases. CONCLUSIONS: NDPK kinetics studies indicated substrate dependency of NDPK and a &quot;ping-pong&quot; mechanism for production inhibition. Skewness distributions of NDPK activity levels were shown in the study population. The transplant recipients showed higher NDPK activity levels when compared to healthy subjects

Case report: Clinical complete response in advanced ALK-positive lung squamous cell carcinoma: a case study of successful anti-PD-1 immunotherapy post ALK-TKIs failure

In patients with advanced lung adenocarcinoma (LADC) harboring the echinoderm microtubule-associated protein-like 4 (EML4) -anaplastic lymphoma kinase (ALK) rearrangement, targeted therapy typically demonstrates superior efficacy as an initial treatment compared to chemotherapy. Following resistance to ALK-tyrosine kinase inhibitors (TKIs), regimens incorporating platinum-based dual agents or combined with bevacizumab often show effectiveness. However, therapeutic alternatives become constrained after resistance develops to both TKIs and platinum-based therapies. Given that the majority of ALK-positive non-small cell lung carcinomas (NSCLC) are LADC, the benefits of TKIs for patients with ALK-positive lung squamous cell carcinoma (LSCC) and the optimal treatment strategy for these patients remain a subject of debate. In this case study, we report on a patient with advanced LSCC, in whom the EML4-ALK rearrangement was identified via ARMS-PCR (Amplification Refractory Mutation System-Polymerase Chain Reaction). The patient underwent oral treatment with crizotinib and alectinib, showing effectiveness in both first-line and second-line ALK-TKI therapies, albeit with limited progression-free survival (PFS). Subsequent resistance to second-generation TKI was followed by the detection of tumors in the left neck region via computed tomography (CT). Biopsy pathology revealed non-squamous cell carcinoma, and subsequent treatment with platinum-based double-drug therapy proved ineffective. Further analysis through next-generation sequencing (NGS) indicated ALK negativity but a high expression of programmed death-ligand 1 (PD-L1). Immunotherapy was then initiated, resulting in a PFS of over 29 months and clinical complete remission (cCR). This case underscores the potential benefit of ALK-TKIs in patients with ALK-positive LSCC. Resistance to second-generation TKIs may lead to ALK negativity and histological transformation, highlighting the necessity of repeated biopsies post-TKI resistance for informed treatment decision-making. As of November 2023, imaging studies continue to indicate cCR in the patient, with a survival time exceeding 47 months

Research hotspots and new trends in the impact of resistance training on aging, bibliometric and visual analysis based on CiteSpace and VOSviewer

PurposeResistance training (RT) can intervene in aging, which can effectively improve trainees’ life. However, unhealthy living habits such as irregular life, obesity and hyperlipidemia, and chronic diseases lead to a significant decline in the energy level of the population, seriously affecting the health of the population. Our research identifies the research hotspots of RT to intervene in aging from the perspective of bibliometrics, predicts research frontiers and development trends, and provides more perspectives for research on aging populations.MethodsIn this study, we used CiteSpace and VOSviewer visualization software to draw the scientific knowledge map of countries/regions, institutions, authors, co-occurrence keywords, and co-cited references of published articles, and explore the Web of Science core collection database all about the RT intervention aging research status, hotspots, frontiers, and development trends of articles on aging.ResultsAmong the 760 articles that meet the inclusion criteria, the number of articles published and the frequency of citations have increased steadily in the past 5 years. Judging from the countries/regions, institutions, scholars, and journals that published articles, the ones with the largest numbers are the USA, Univ Estadual Londrina, Cyrino ES, and Exp Gerontol. The ones with the highest influence are England, Univ Arkansas Med Sci, Frontera WR, and Biochem Biophys Rep Co. The top five co-occurrence keywords of include exercise, strength, resistance training, skeletal muscle, and muscle strength. The research frontier is physical function.ConclusionIn the field of RT intervention aging research, relevant scholars deserve further in-depth research and exploration. The United States, Brazil, Canada, and other economically developed countries/regions, institutions, and authors have greater influence and productivity. These quantitative research results can provide references for relevant scholars’ follow-up research and government departments to formulate and modify health policies or measures

Activation of the IL-23/Th17 Axis

The aim of this paper is to determine the modulatory effects of Lactobacillus acidophilus on the IL-23/Th17 immune axis in experimental colitis. DSS-induced mouse models of UC were to be saline, hormones, and different concentrations of Lactobacillus acidophilus intervention. The expression of interleukin-(IL-) 17, tumor necrosis factor (TNF ), IL-23, transforming growth factor 1 (TGF 1), signal transducer and activator of transcription 3 (STAT3), and phosphorylated (p)-STAT3 was examined by RT-PCR, Western blotting, and immunohistochemical analysis. And the results showed that administration of L. acidophilus suppressed Th17 cell-mediated secretion of proinflammatory cytokine IL-17 through downregulation of IL-23 and TGF 1 expression and downstream phosphorylation of p-STAT3