<原著>一次性外傷性動眼神経麻痺症例の検討

頭部外傷による一次性動眼神経麻痺症例13例について検討した. 発生頻度は, 過去8. 5年間に入院した頭部外傷症例1052例中13例(1. 2%)であった. 年齢は7歳から83歳(平均32歳)で, 男7例, 女6例であった. 受傷機転は全例交通外傷で, 受傷部位は前頭部8例, 後頭部3例, 側頭部1例で, 1例は不明であった. 入院時の意識レベルは, Glasgow Coma Scale で4点から14点(平均7点)であった. 頭蓋単純写で骨折が3例に認められた. CT では, くも膜下出血が4例, 脳室内出血が2例, 脳挫傷が5例に認められた. MRI は4例に施行され, 3例に脳挫傷が認められた. 予後は6カ月の観察期間で, 完全回復10例, 不完全回復2例, 不変1例であった. 今回検討した症例では, 前後方向の外力により, tentorial gap で動眼神経の損傷をきたした症例が多いと考えられた. 予後は比較的良好であった

Hemorrhagic Arachnoid Cyst of the Posterior : A Case Report

Arachnoid cysts are reported to be occasionally associated with subdural hematoma or hygroma. Spontaneous disappearances of arachnoid cysts have been reported previously and in was emphasized that rupture of cyst membrane and subdural hematoma or hygroma must be essential for them to disappear. We report herein a case of hemorrhagic arachnoid cyst of the posterior fossa. The hemorrhagic cyst was not accompanied by subdural hematoma or hygroma and gradually reduced in size. A 21-year-old man sustained a cerebral contusion and epidural hematoma of the frontal reglon from a head injury. Computerized tomography scannlng obtained 12 hours after the inJury revealed a hemorrhagic retrocerebellar arachnoid cyst. Magnetic resonance imaging performed on day 21 revealed that the hemorrhagic arachnoid cyst had high intensity on a T1-weighted image and relatively low intensity on a T2- weighted image without subdural hematoma or hygroma. Follow-up CT scans revealed that the hemorrhagic arachnoid cyst had reduced in size. The patient made an almost complete recovery and was discharged with no observable neurologlcal deficits three months after admission. Hemorrhage was not presentin the first few hours after head injury but developed Subsequently, confined strictly to the cystic cavity. This case report provides evidence that disappearance or reduction of arachnoid cysts can occur without the need for subdural hematoma or effusion

CCDC 850155: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures

Small-molecule-induced clustering of heparan sulfate promotes cell adhesion

Adhesamine is an organic small molecule that promotes adhesion and growth of cultured human cells by binding selectively to heparan sulfate on the cell surface. The present study combined chemical, physicochemical, and cell biological experiments, using adhesamine and its analogues, to examine the mechanism by which this dumbbell-shaped, non-peptidic molecule induces physiologically relevant cell adhesion. The results suggest that multiple adhesamine molecules cooperatively bind to heparan sulfate and induce its assembly, promoting clustering of heparan sulfate-bound syndecan-4 on the cell surface. A pilot study showed that adhesamine improved the viability and attachment of transplanted cells in mice. Further studies of adhesamine and other small molecules could lead to the design of assembly-inducing molecules for use in cell biology and cell therapy

Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion

Adhesamine is an organic small molecule that promotes adhesion and growth of cultured human cells by binding selectively to heparan sulfate on the cell surface. The present study combined chemical, physicochemical, and cell biological experiments, using adhesamine and its analogues, to examine the mechanism by which this dumbbell-shaped, non-peptidic molecule induces physiologically relevant cell adhesion. The results suggest that multiple adhesamine molecules cooperatively bind to heparan sulfate and induce its assembly, promoting clustering of heparan sulfate-bound syndecan-4 on the cell surface. A pilot study showed that adhesamine improved the viability and attachment of transplanted cells in mice. Further studies of adhesamine and other small molecules could lead to the design of assembly-inducing molecules for use in cell biology and cell therapy

Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion

Adhesamine is an organic small molecule that promotes adhesion and growth of cultured human cells by binding selectively to heparan sulfate on the cell surface. The present study combined chemical, physicochemical, and cell biological experiments, using adhesamine and its analogues, to examine the mechanism by which this dumbbell-shaped, non-peptidic molecule induces physiologically relevant cell adhesion. The results suggest that multiple adhesamine molecules cooperatively bind to heparan sulfate and induce its assembly, promoting clustering of heparan sulfate-bound syndecan-4 on the cell surface. A pilot study showed that adhesamine improved the viability and attachment of transplanted cells in mice. Further studies of adhesamine and other small molecules could lead to the design of assembly-inducing molecules for use in cell biology and cell therapy