953 research outputs found
The Role of Translation Initiation Regulation in Haematopoiesis
Organisation of RNAs into functional subgroups that are translated in response to extrinsic and intrinsic factors underlines a relatively unexplored gene expression modulation that drives cell fate in the same manner as regulation of the transcriptome by transcription factors. Recent studies on the molecular mechanisms of inflammatory responses and haematological disorders indicate clearly that the regulation of mRNA translation at the level of translation initiation, mRNA stability, and protein isoform synthesis is implicated in the tight regulation of gene expression. This paper outlines how these posttranscriptional control mechanisms, including control at the level of translation initiation factors and the role of RNA binding proteins, affect hematopoiesis. The clinical relevance of these mechanisms in haematological disorders indicates clearly the potential therapeutic implications and the need of molecular tools that allow measurement at the level of translational control. Although the importance of miRNAs in translation control is well recognised and studied extensively, this paper will exclude detailed account of this level of control
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CAPILLARY BARRIERS IN UNSATURATED FRACTURED ROCKS
This work presents modeling studies investigating the effects of capillary barriers on fluid-flow and tracer-transport processes in the unsaturated zone of Yucca Mountain, Nevada, a potential site for storing high-level radioactive waste. These studies are designed to identify factors controlling the formation of capillary barriers and to estimate their effects on the extent of possible large-scale lateral flow in unsaturated fracture rocks. The modeling approach is based on a continuum formulation of coupled multiphase fluid and tracer transport through fractured porous rock. Flow processes in fractured porous rock are described using a dual-continuum concept. In addition, approximate analytical solutions are developed and used for assessing capillary-barrier effects in fractured rocks. This study indicates that under the current hydrogeologic conceptualization of Yucca Mountain, strong capillary-barrier effects exist for significantly diverting moisture flow
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Analyzing Unsatirated Flow Patterns in Fractured Rock Using an Integrated Modeling Approach
Characterizing percolation patterns in unsaturated fractured rock has posed a greater challenge to modeling investigations than comparable saturated zone studies, because of the heterogeneous nature of unsaturated media and the great number of variables impacting unsaturated flow. This paper presents an integrated modeling methodology for quantitatively characterizing percolation patterns in the unsaturated zone of Yucca Mountain, Nevada, a proposed underground repository site for storing high-level radioactive waste. The modeling approach integrates a wide variety of moisture, pneumatic, thermal, and isotopic geochemical field data into a comprehensive three-dimensional numerical model for modeling analyses. It takes into account the coupled processes of fluid and heat flow and chemical isotopic transport in Yucca Mountain's highly heterogeneous, unsaturated fractured tuffs. Modeling results are examined against different types of field-measured data and then used to evaluate different hydrogeological conceptualizations and their results of flow patterns in the unsaturated zone. In particular, this model provides a much clearer understanding of percolation patterns and flow behavior through the unsaturated zone, both crucial issues in assessing repository performance. The integrated approach for quantifying Yucca Mountain's flow system is demonstrated to provide a practical modeling tool for characterizing flow and transport processes in complex subsurface systems
China’s emerging global role: dissatisfied responsible great power
China has (re)emerged as a great power in a world not of its own making. The distribution of power in major organisations and the dominant norms of international interactions are deemed to unfairly favour the existing Western powers, and at times obstruct China’s ability to meet national development goals. Nevertheless, engaging the global economy has been a key source of economic growth (thus helping to maintain regime stability), and establishing China’s credentials as a responsible global actor is seen as a means of ensuring continued access to what China needs. As an emerging great power that is also still in many respects a developing country, China’s challenge is to change the global order in ways that do not cause global instability or generate crises that would damage China’s own ability to generate economic growth and ensure political stability
The fermion dynamical symmetry model for the even--even and even--odd nuclei in the Xe--Ba region
The even--even and even--odd nuclei Xe-Xe and
Ba-Ba are shown to have a well-realized fermion dynamical symmetry. Their low-lying energy levels can be
described by a unified analytical expression with two (three) adjustable
parameters for even--odd (even--even) nuclei that is derived from the fermion
dynamical symmetry model. Analytical expressions are given for wavefunctions
and for transition rates that agree well with data. The distinction
between the FDSM and IBM limits is discussed. The experimentally
observed suppression of the the energy levels with increasing quantum
number can be explained as a perturbation of the pairing interaction on
the symmetry, which leads to an Pairing effect for nuclei.Comment: submitted to Phys. Rev. C, LaTeX, 31 pages, 8 figures with postscript
files available on request at [email protected]
Effects of domain walls on hole motion in the two-dimensional t-J model at finite temperature
The t-J model on the square lattice, close to the t-J_z limit, is studied by
quantum Monte Carlo techniques at finite temperature and in the underdoped
regime. A variant of the Hoshen-Koppelman algorithm was implemented to identify
the antiferromagnetic domains on each Trotter slice. The results show that the
model presents at high enough temperature finite antiferromagnetic (AF) domains
which collapse at lower temperatures into a single ordered AF state. While
there are domains, holes would tend to preferentially move along the domain
walls. In this case, there are indications of hole pairing starting at a
relatively high temperature. At lower temperatures, when the whole system
becomes essentially fully AF ordered, at least in finite clusters, holes would
likely tend to move within phase separated regions. The crossover between both
states moves down in temperature as doping increases and/or as the off-diagonal
exchange increases. The possibility of hole motion along AF domain walls at
zero temperature in the fully isotropic t-J is discussed.Comment: final version, to appear in Physical Review
The phase diagram of quantum systems: Heisenberg antiferromagnets
A novel approach for studying phase transitions in systems with quantum
degrees of freedom is discussed. Starting from the microscopic hamiltonian of a
quantum model, we first derive a set of exact differential equations for the
free energy and the correlation functions describing the effects of
fluctuations on the thermodynamics of the system. These equations reproduce the
full renormalization group structure in the neighborhood of a critical point
keeping, at the same time, full information on the non universal properties of
the model. As a concrete application we investigate the phase diagram of a
Heisenberg antiferromagnet in a staggered external magnetic field. At long
wavelengths the known relationship to the Quantum Non Linear Sigma Model
naturally emerges from our approach. By representing the two point function in
an approximate analytical form, we obtain a closed partial differential
equation which is then solved numerically. The results in three dimensions are
in good agreement with available Quantum Monte Carlo simulations and series
expansions. More refined approximations to the general framework presented here
and few applications to other models are briefly discussed.Comment: 17 pages, 7 figure
Shot noise in normal metal-d-wave superconducting junctions
We present theoretical calculations and predictions for the shot noise in
voltage biased junctions of superconductors and normal metal
counter-electrodes. In the clean limit for the d-wave superconductor the shot
noise vanishes at zero voltage because of resonant Andreev reflection by
zero-energy surface bound states. We examine the sensitivity of this resonance
to impurity scattering. We report theoretical results for the magnetic field
dependence of the shot noise, as well the fingerprints of subdominant - and
pairing channels.Comment: 15 pages, 8 figures and 3 tables embedde
Influence of impurity scattering on tunneling conductance in normal metal- d -wave superconductor junctions
Tunneling conductance spectra between a normal metal / d-wave superconductor
junction under the presence of bulk impurities in the superconductor are
studied. The quasiclassical theory has been applied to calculate the spatial
variation of the pair potential and the effect of impurity scattering has been
introduced by t-matrix approximation. The magnitude of a subdominant s-wave
component at the interface is shown to robust against the impurity scattering
while that for a subdominant -wave component is largely suppressed with
the increase of the impurity scattering rate. The zero-bias conductance peak
due to the zero-energy Andreev bound states is significantly broadened for the
case of Born limit impurity compared with that of unitary limit impurity.Comment: 14 pages, 5 figure
Muon spin relaxation studies of incommensurate magnetism and superconductivity in stage-4 LaCuO and LaSrCuO
This paper reports muon spin relaxation (MuSR) measurements of two single
crystals of the title high-Tc cuprate systems where static incommensurate
magnetism and superconductivity coexist. By zero-field MuSR measurements and
subsequent analyses with simulations, we show that (1) the maximum ordered Cu
moment size (0.36 Bohr magneton) and local spin structure are identical to
those in prototypical stripe spin systems with the 1/8 hole concentration; (2)
the static magnetism is confined to less than a half of the volume of the
sample, and (3) regions with static magnetism form nano-scale islands with the
size comparable to the in-plane superconducting coherence length. By
transverse-field MuSR measurements, we show that Tc of these systems is related
to the superfluid density, in the same way as observed in cuprate systems
without static magnetism. We discuss a heuristic model involving percolation of
these nanoscale islands with static magnetism as a possible picture to
reconcile heterogeneity found by the present MuSR study and long-range spin
correlations found by neutron scattering.Comment: 19 pages, 15 figures, submitted to Phys. Rev. B. E-mail:
[email protected]
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