Многоцентровое исследование эффективности неоадъювантной терапии САРОХ/бевацизумаб у неоперабельных больных с метастазами колоректального рака в печени

Проанализированы результаты многоцентрового исследования II фазы, в котором показана эффективность и безопасность комбинации режима CAPOX с бевацизумабом при неоадъювантной терапии не подлежащих хирургическому лечению пациентов с метастазами колоректального рака в печени: резектабельность последних была достигнута в 44% случаев, 12-месячная выживаемость: общая – 96%, безрецидивная – 50%. Ключевые слова: колоректальный рак, метастазы в печени, бевацизумаб, капецитабин, оксалиплатин.The results of multicentre study of II phase are analyzed. The efficacy and safety of combined regimen CAPOX + bevacizumab in adjuvant therapy of patients not selected for upfront resection and with colorectal cancer metastasis in liver is demonstrated. The respectability was achieved in 44% of cases, 12-month survival, overall, survival 96%, without relapse 50%. Key Words: bevacizumab, capecitabine, colorectal cancer, liver metastases, oxaliplati

Study of the decay mechanism for B+ to p pbar K+ and B+ to p pbar pi+

We study the characteristics of the low mass ppbar enhancements near threshold in the three-body decays B+ to p pbar K+ and B+ to p pbar pi+. We observe that the proton polar angle distributions in the ppbar helicity frame in the two decays have the opposite polarity, and measure the forward-backward asymmetries as a function of the ppbar mass for the p pbar K+ mode. We also search for the intermediate two-body decays, B+ to pbar Delta++ and B+ to p Delta0bar, and set upper limits on their branching fractions. These results are obtained from a 414 fb^{-1} data sample that contains 449 times 10^6 BBbar events collected near the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+ e- collider.Comment: 15 pages, 5 figures (14 figure files), revisions to Phys. Lett.

WS 2 Nano-petals and Nano-bristles Supported on Carbon Nanotubes for Electron Emission Applications

10.1038/s41598-019-39605-4Scientific Reports91367

Impurity free vacancy disordering of InAs/GaAs quantum dot and InAs/InGaAs dot-in-a-well structures

10.1016/j.tsf.2006.11.011Thin Solid Films5157-83927-3931THSF

One-dimensional aligned InAs/InP quantum dots chain growth by metalorganic vapor phase epitaxy for 1.55 μm application

10.1016/j.jcrysgro.2007.04.024Journal of Crystal Growth305145-49JCRG

X-ray photoelectron spectroscopic study of InGaAsN grown by MOCVD

Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS2624-625CPLS

Multiple artificial microRNAs targeting conserved motifs of the replicase gene confer robust transgenic resistance to negative-sense single-stranded RNA plant virus

MicroRNAs (miRNAs) regulate the abundance of target mRNAs by guiding cleavage at sequence complementary regions. In this study, artificial miRNAs (amiRNAs) targeting conserved motifs of the L (replicase) gene of Watermelon silver mottle virus (WSMoV) were constructed using Arabidopsis pre-miRNA159a as the backbone. The constructs included six single amiRNAs targeting motifs A, B1, B2, C, D of E, and two triple amiRNAs targeting motifs AB1E or B2DC. Processing of pre-amiRNAs was confirmed by agro-infiltration, and transgenic Nicotiana benthamiana plants expressing each amiRNA were generated. Single amiRNA transgenic lines expressing amiR-LB2 or amiR-LD showed resistance to WSMoV by delaying symptom development. Triple amiRNA lines expressing amiR-LB2, amiR-LD and amiR-LC provided complete resistance against WSMoV, with no indication of infection 28 days after inoculation. Resistance levels were positively correlated with amiRNA expression levels in these single and triple amiRNA lines. The triple amiR-LAB1E line did not provide resistance to WSMoV. Similarly, the poorly expressed amiR-LC and amiR-LE lines did not provide resistance to WSMoV. The amiR-LA- and amiR-LB1-expressing lines were susceptible to WSMoV, and their additional susceptibility to the heterologous Turnip mosaic virus harbouring individual target sequences indicated that these two amiRNAs have no effect in vivo. Transgenic lines expressing amiR-LB2 exhibited delayed symptoms after challenge with Peanut bud necrosis virus having a single mismatch in the target site. Overall, our results indicate that two amiRNAs, amiR-LB2 and amiR-LD, of the six designed amiRNAs confer moderate resistance against WSMoV, and the triple construct including the two amiRNAs provides complete resistance

P-type doping in GaN through Be implantation

10.1002/pssc.200461458Physica Status Solidi C: Conferences272415-241